Antibiotic resistance in elderly patients: Comparison of Enterobacterales causing urinary tract infections between community, nursing homes and hospital settings

Biguenet, Adrien; Bouxom, Hélène; Bertrand, Xavier; Slekovec, C.

doi:10.1016/j.idnow.2022.12.005

Infectious Diseases Now

2023

DOI: 10.1016/j.idnow.2022.12.005

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Antibiotic resistance in elderly patients: Comparison of Enterobacterales causing urinary tract infections between community, nursing homes and hospital settings

Adrien Biguenet

Hélène Bouxom

Xavier Bertrand

et al.

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2024

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Cited by 2 publications

References 16 publications

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Immune aging and infectious diseases

Chen,

Zou,

Chen

et al. 2024

Chinese Medical Journal

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The rise in global life expectancy has led to an increase in the older population, presenting significant challenges in managing infectious diseases. Aging affects the innate and adaptive immune systems, resulting in chronic low-grade inflammation (inflammaging) and immune function decline (immunosenescence). These changes would impair defense mechanisms, increase susceptibility to infections and reduce vaccine efficacy in older adults. Cellular senescence exacerbates these issues by releasing pro-inflammatory factors, further perpetuating chronic inflammation. Moreover, comorbidities, such as cardiovascular disease and diabetes, which are common in older adults, amplify immune dysfunction, while immunosuppressive medications further complicate responses to infections. This review explores the molecular and cellular mechanisms driving inflammaging and immunosenescence, focusing on genomic instability, telomere attrition, and mitochondrial dysfunction. Additionally, we discussed how aging-associated immune alterations influence responses to bacterial, viral, and parasitic infections and evaluated emerging antiaging strategies, aimed at mitigating these effects to improve health outcomes in the aging population.

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Immune aging and infectious diseases

Chen,

Zou,

Chen

et al. 2024

Chinese Medical Journal

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Antimicrobial Resistance: The Impact from and on Society According to One Health Approach

Ferraz

2024

Societies

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Antibiotics are drugs that target and destroy bacteria, and they are hailed as one of the most amazing medical breakthroughs of the 20th century. They have completely changed how we treat infections and have saved countless lives. But their usefulness is not limited to just medicine; they have also been used for many years in sectors like farming to prevent infections in animals, especially in less wealthy countries. Antimicrobial resistance (AMR) is the ability of microorganisms such as bacteria, viruses, fungi, and parasites to resist the effects of antimicrobial agents, like antibiotics, antivirals, antifungals, and antiparasitics, that were once effective in treating infections caused by these organisms. AMR presents an intricate challenge that endangers the health of both humans and animals, as well as the global economy, and the security of nations and the world at large. Because resistant bacteria are swiftly appearing and spreading among humans, animals, and the environment worldwide, AMR is acknowledged as a challenge within the framework of One Health. The One Health approach involves cooperation among various fields to attain the best possible health outcomes for humans, animals, and the environment. It acknowledges the interconnectedness of human, animal, and environmental health. AMR is not merely a scientific or medical issue; it is a societal challenge that demands collective action and awareness. In the intricate tapestry of society, every thread contributes to the fabric of AMR, and every individual holds a stake in its resolution.

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Antibiotic resistance in elderly patients: Comparison of Enterobacterales causing urinary tract infections between community, nursing homes and hospital settings

Cited by 2 publications

References 16 publications

Immune aging and infectious diseases

Immune aging and infectious diseases

Antimicrobial Resistance: The Impact from and on Society According to One Health Approach

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