Antibiotic Resistance in Extra Intestinal Pathogenic Escherichia Coli

Chakraborty, Arindam

doi:10.15406/jmen.2017.04.00122

Cited by 1 publication

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References 12 publications

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“…Twelve isolates had more than one type of ESBL, where CTX-M + TEM were found in 7 (16.67%) isolates, CTX-M + SHV were observed in 11.9% of isolates and 4.76% of isolates had TEM + SHV genes. The same order of gene type presence, but with different percentages, was reported by Chakraborty et al [34] in India, where the CTX-M gene was detected in 88% of E. coli, followed by TEM (19%) and SHV (2%). In addition, the same pattern was mentioned by Zhao et al [35] in China, who reported that the rate of CTX-M, TEM, and SHV among E. coli isolates was 42.5%, 4.2%, and 0.8%, respectively.…”

Section: Discussionsupporting

confidence: 73%

Multiple Drug Resistance Patterns in Various Phylogenetic Groups of Hospital-Acquired Uropathogenic E. coli Isolated from Cancer Patients

et al. 2020

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Cancer patients are more susceptible to several bacterial infections, particularly urinary tract infections caused by uropathogenic E. coli (UPEC). The objective of this work was detection and the phylogenetic characterization of hospital-acquired isolates of uropathogenic E. coli in cancer patients and the determination of its relation with antibiotic resistance. A total of 110 uropathogenic E. coli responsible for hospital-acquired urinary tract infections in cancer patients were included in this study. A triplex PCR was employed to segregate different isolates into four different phylogenetic groups (A, B1, B2 and D). Drug resistance was evaluated by the disc diffusion method. All of the isolates were multiple drug-resistant (MDR) and 38.18% of all UPEC isolates were extended-spectrum beta-lactamase (ESBL) producers from which 52% were positive for the blaCTX-M gene, 40% for the blaTEM gene, and 17% for the blaSHVgene. Among 42 ESBL-producing uropathogenic E. coli isolates, the majority belonged to phylogenetic group B2 (43%), followed by group D (36%), group A (19%) and group B1 (2%). Our results have shown the emergence of MDR isolates among uropathogenic E. coli with the dominance of phylogenetic group B2. Groups A and B1 were relatively less common. The most effective drug in all phylogenetic groups was imipenem.

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Section: Discussionsupporting

confidence: 73%