Antibiotic resistance in Helicobacter pylori

Teare, Louise; Saverymuttu, Seth; Owen, Robert J.; Tiwari, Indrajit; Peters, Tansy

doi:10.1016/s0140-6736(05)77257-3

Cited by 19 publications

(12 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the number of clarithromycin-resistant isolates is small, our rate was in line with the pre-treatment dualresistance rate of 6 % in Chelmsford (Teare et al, 1999). In the European study of pre-treatment isolates, dual resistance was observed in 14 centres and exceeded 5 % in eight of them (Glupczynski et al, 2002).…”

Section: Discussionsupporting

confidence: 83%

“…Lower rates were reported in other European locations, for instance 4 % in Northern Europe (Glupczynski et al, 2001) and in Chelmsford (Teare et al, 1999), 5 % in Suffolk (Cameron et al, 2004) and 7 % in Bangor (Elviss et al, 2004a). Although the number of isolates from inner London was insufficient to establish any significant sex-or age-related differences in resistance rates, it was found in the multicentre European study that resistance to clarithromycin was significantly higher in children and in teenagers.…”

Section: Discussionmentioning

confidence: 86%

“…Our rate had the highest similarity to the 62 % rate recorded in Helsinki, Finland (Glupczynski et al, 2001). Previous single-centre studies in England reported lower metronidazole-resistance rates of 29 % for Gloucester (Glupczynski et al, 2001), 32 % for Bangor (Elviss et al, 2004a) and Ipswich (Cameron et al, 2004), 36 % for Chelmsford (Teare et al, 1999) and 40 % for Sheffield (Parsons et al, 2001). It is important to note, however, when comparing different sets of data that the significance of variations between rates in the order of 5 % cannot be precisely assessed, because of the possible effects of interlaboratory reproducibility caused by the lack of standardized testing protocols, particularly for metronidazole (Glupczynski et al, 2002).…”

Section: Discussionmentioning

confidence: 93%

“…There is no systematic surveillance of primary antibiotic resistance in London, the largest ethnically diverse metropolitan area in the UK, although widely divergent rates depending on patient ethnic origin were reported in a single-centre study in east London (Banatvala et al, 1994). Resistance rates of 29-40 % for metronidazole and 1-7 % for clarithromycin have been reported for several regional populations in England, notably Ipswich (Cameron et al, 2004), Gloucester (Glupczynski et al, 2001), Sheffield (Parsons et al, 2001), Chelmsford (Teare et al, 1999) and north Wales (Elviss et al, 2004a).…”

Section: Introductionmentioning

confidence: 98%

See 3 more Smart Citations

Helicobacter pylori antibiotic-resistance patterns and risk factors in adult dyspeptic patients from ethnically diverse populations in central and south London during 2000

Elviss

Owen

Breathnach

et al. 2005

Journal of Medical Microbiology

View full text Add to dashboard Cite

Surveillance of Helicobacter pylori antibiotic susceptibility from patients in London, the largest metropolitan area in the UK, is limited, despite resistance being a key factor in treatment failure. A two-centre survey was performed over 12 months (1999)(2000) to determine antibiotic-resistance rates of isolates from dyspeptic patients attending endoscopy clinics serving two ethnically diverse central and south London communities. The in vitro antibiotic susceptibilities were determined from disc diffusion and epsilometer (E) tests on 101 H. pylori isolates. Overall resistance rates were 59 % for metronidazole and 11 % for clarithromycin, with 8 % resistance to both antibiotics. Corresponding primary resistance rates were 50 % and 7 %, respectively. High-level-resistance was a feature of 82 % of the metronidazole (MIC > 256 mg l À1 ) -resistant and 55 % of the clarithromycin (MIC > 32 mg l À1 ) -resistant strains. All isolates were susceptible to amoxycillin and tetracycline. No associations between resistance and either the gender or the age of the patients were detected. The main risk for resistance to metronidazole was non-UK birth as comparative rates were 68 % for non-UK vs. 40 % for UK-born individuals. Resistant isolates were genotypically diverse with respect to cagA/vacA type. Four 23S rDNA nucleotide polymorphisms were associated with clarithromycin resistance, mostly (9/11) at A2143G. In conclusion, the high overall metronidazole-resistance rate of 59 % for H. pylori from inner London was twice the rate found in other UK-based studies and was attributed to the higher risk of resistant strains infecting individuals born outside the UK. The need for continued resistance surveillance is indicated to monitor the effects of the 'test and treat' strategy for H. pylori eradication, particularly of isolates from at-risk individuals

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Helicobacter pylori antibiotic-resistance patterns and risk factors in adult dyspeptic patients from ethnically diverse populations in central and south London during 2000

Elviss

Owen

Breathnach

et al. 2005

Journal of Medical Microbiology

View full text Add to dashboard Cite

show abstract

“…Other studies did not show a significant gender difference (29,53). Finally, lower rates of resistance to MET or/and CLR in male patients have been reported all over the world (25,40,42,45,50,52). High rates of MET resistance in females could be due to the use of this drug to treat gynecological infections.…”

Section: Discussionmentioning

confidence: 90%

Multicenter Survey of Routine Determinations of Resistance of Helicobacter pylori to Antimicrobials over the Last 20 Years (1990 to 2009) in Belgium

et al. 2011

View full text Add to dashboard Cite

We analyzed the rates of antimicrobial resistance of Helicobacter pylori strains isolated from patients from 1990 to 2009 and identified risk factors associated with resistance. Gastric biopsy specimens were collected from several digestive disease centers in Brussels, Belgium. We routinely performed antimicrobial susceptibility testing for clarithromycin (CLR), metronidazole, amoxicillin, tetracycline, and ciprofloxacin. Evaluable susceptibility testing was obtained for 9,430 strains isolated from patients who were not previously treated for Helicobacter pylori infection (1,527 isolates from children and 7,903 from adults) and 1,371 strains from patients who were previously treated (162 isolates from children and 1,209 from adults). No resistance to amoxicillin was observed, and tetracycline resistance was very rare (<0.01%). Primary metronidazole resistance remained stable over the years, with significantly lower rates for isolates from children (23.4%) than for isolates from adults (30.6%). Ciprofloxacin resistance remained rare in children, while it increased significantly over the last years in adults. Primary clarithromycin resistance increased significantly, reaching peaks in 2000 for children (16.9%) and in 2003 for adults (23.7%). A subsequent decrease of resistance rates down to 10% in both groups corresponded to a parallel decrease in macrolide consumption during the same period. Multivariate logistic regression revealed that female gender, age of the patient of 40 to 64 years, ethnic background, the number of previously unsuccessful eradication attempts, and the different time periods studied were independent risk factors of resistance to clarithromycin, metronidazole, and ciprofloxacin. Our study highlights the need to update local epidemiological data. Thus, the empirical CLR-based triple therapy proposed by the Maastricht III consensus report remains currently applicable to our population.

show abstract

Helicobacter

Owen¹

2010

Topley &Amp; Wilson's Microbiology and Microbial Infections

View full text Add to dashboard Cite

Antibiotic resistance in Helicobacter pylori

Cited by 19 publications

References 5 publications

Helicobacter pylori antibiotic-resistance patterns and risk factors in adult dyspeptic patients from ethnically diverse populations in central and south London during 2000

Helicobacter pylori antibiotic-resistance patterns and risk factors in adult dyspeptic patients from ethnically diverse populations in central and south London during 2000

Multicenter Survey of Routine Determinations of Resistance of Helicobacter pylori to Antimicrobials over the Last 20 Years (1990 to 2009) in Belgium

Helicobacter

Contact Info

Product

Resources

About