Antibiotic Resistance in Pseudomonas

Laborda, Pablo; Hernando-Amado, Sara; Martínez, José Luis; Sanz-García, Fernando

doi:10.1007/978-3-031-08491-1_5

Cited by 24 publications

(23 citation statements)

References 244 publications

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“…From whole-genome sequencing experiments of this pathogen, exposure to different classes of antibiotics (β-lactams, fluoroquinolones, and aminoglycosides) drives stress evolution, leading to the alarming CR level in the hospital setting [ 25 , 26 , 27 ]. The success of P. aeruginosa in colonizing different habitats largely relies on its metabolic versatility and robustness making it difficult to eradicate this pathogen from the nosocomial environment [ 28 ]. The complexity of this microorganism causes limitations in overcoming quinolone or carbapenem resistance with standard ASPs [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Carbapenem-Resistant Pseudomonas aeruginosa Bacteremia, through a Six-Year Infection Control Program in a Hospital

Papanikolopoulou

Gargalianos‐Kakolyris

Stoupis

et al. 2023

Microorganisms

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Background: Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a life-threatening healthcare-associated infection affecting especially patients with immunosuppression and comorbidities. We investigated the association between the incidence of CRPA bacteremia, antibiotic consumption, and infection control measures in a hospital during 2013–2018. Methods: We prospectively recorded the incidence of CRPA bacteremia, antibiotic consumption, use of hand-hygiene solutions, and isolation rates of multidrug-resistant (MDR) carrier patients. Findings: The consumption of colistin, aminoglycosides, and third-generation cephalosporins decreased significantly in the total hospital and its divisions (p-value < 0.001 for all comparisons) while the consumption of carbapenems decreased significantly in the adults ICU (p-value = 0.025). In addition, the incidence of CRPA significantly decreased in the total hospital clinics and departments (p-values = 0.027 and 0.042, respectively) and in adults clinics and departments (p-values = 0.031 and 0.051, respectively), while in the adults ICU, the incidence remained unchanged. Increased isolation rates of MDR carrier patients, even two months before, significantly correlated with decreased incidence of CRPA bacteremia (IRR: 0.20, 95% CI: 0.05–0.73, p-value = 0.015) in the adults ICU. Interestingly, when the use of hand-hygiene solutions (alcohol and/or scrub) increased, the consumption of advanced, nonadvanced, and all antibiotics decreased significantly. Conclusion: In our hospital, multimodal infection control interventions resulted in a significant reduction of CRPA bacteremia, mostly due to the reduction of all classes of antibiotics.

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Section: Discussionmentioning

confidence: 99%

Carbapenem-Resistant Pseudomonas aeruginosa Bacteremia, through a Six-Year Infection Control Program in a Hospital

Papanikolopoulou

Gargalianos‐Kakolyris

Stoupis

et al. 2023

Microorganisms

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“…Contrary to intrinsic resistance, the development of acquired resistance is highly influenced by external stressors, such as exposure to antibiotics. In the presence of such compounds, resistant bacteria present a selective advantage over susceptible strains; this way, the surviving bacteria will give rise to a resistant population [ 106 , 107 , 108 , 109 ].…”

Section: Antibiotic Resistancementioning

confidence: 99%

“…If its new traits are beneficial for the bacteria and contribute to its survival in adverse conditions, they will probably become predominant as they are transmitted to subsequent generations [ 110 ]. In P. aeruginosa , mutations can result in modifications of antibiotic targets or porin channels, and therefore in a reduced antibiotic uptake, or in the increased expression of resistance genes, and consequently in the overproduction of antibiotic-inactivating enzymes and multidrug efflux pumps [ 106 , 109 , 111 ].…”

Section: Antibiotic Resistancementioning

confidence: 99%

Mechanisms of Antibiotic and Biocide Resistance That Contribute to Pseudomonas aeruginosa Persistence in the Hospital Environment

Verdial¹,

Serrano

Tavares

et al. 2023

Biomedicines

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Pseudomonas aeruginosa is an opportunistic bacterial pathogen responsible for multiple hospital- and community-acquired infections, both in human and veterinary medicine. P. aeruginosa persistence in clinical settings is worrisome and is a result of its remarkable flexibility and adaptability. This species exhibits several characteristics that allow it to thrive under different environmental conditions, including the ability to colonize inert materials such as medical equipment and hospital surfaces. P. aeruginosa presents several intrinsic mechanisms of defense that allow it to survive external aggressions, but it is also able to develop strategies and evolve into multiple phenotypes to persevere, which include antimicrobial-tolerant strains, persister cells, and biofilms. Currently, these emergent pathogenic strains are a worldwide problem and a major concern. Biocides are frequently used as a complementary/combination strategy to control the dissemination of P. aeruginosa-resistant strains; however, tolerance to commonly used biocides has also already been reported, representing an impediment to the effective elimination of this important pathogen from clinical settings. This review focuses on the characteristics of P. aeruginosa responsible for its persistence in hospital environments, including those associated with its antibiotic and biocide resistance ability.

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“…It is also a commensal bacterium transiently inhabiting the digestive tract and skin of humans and animals. Due to its high genomic plasticity and metabolic versatility, P. aeruginosa is able to colonize and cause infection in a wide range of hosts, from unicellular organisms to humans [ 1 , 2 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…The presence of diverse properties encoded in its genome, namely virulence and antimicrobial-resistant determinants, led to the classification of P. aeruginosa as a member of the ESKAPE group (amongst the Enterococcus faecium , Staphylococcus aureus , Klebsiella pneumoniae , Acinetobacter baumannii , and Enterobacter species) [ 4 , 8 ]. The occurrence of multidrug-resistant (MDR) P. aeruginosa strains is a significant medical issue.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Virulence-Factor-Encoding Genes and Genotype Distribution amongst Clinical Pseudomonas aeruginosa Strains

Bogiel

Depka

Kruszewski

et al. 2023

IJMS

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Pseudomonas aeruginosa is an opportunistic pathogen encoding several virulence factors in its genome, which is well-known for its ability to cause severe and life-threatening infections, particularly among cystic fibrosis patients. The organism is also a major cause of nosocomial infections, mainly affecting patients with immune deficiencies and burn wounds, ventilator-assisted patients, and patients affected by other malignancies. The extensively reported emergence of multidrug-resistant (MDR) P. aeruginosa strains poses additional challenges to the management of infections. The aim of this study was to compare the incidence rates of selected virulence-factor-encoding genes and the genotype distribution amongst clinical multidrug-sensitive (MDS) and MDR P. aeruginosa strains. The study involved 74 MDS and 57 MDR P. aeruginosa strains and the following virulence-factor-encoding genes: lasB, plC H, plC N, exoU, nan1, pilA, and pilB. The genotype distribution, with respect to the antimicrobial susceptibility profiles of the strains, was also analyzed. The lasB and plC N genes were present amongst several P. aeruginosa strains, including all the MDR P. aeruginosa, suggesting that their presence might be used as a marker for diagnostic purposes. A wide variety of genotype distributions were observed among the investigated isolates, with the MDS and MDR strains exhibiting, respectively, 18 and 9 distinct profiles. A higher prevalence of genes determining the virulence factors in the MDR strains was observed in this study, but more research is needed on the prevalence and expression levels of these genes in additional MDR strains.

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Antibiotic Resistance in Pseudomonas

Cited by 24 publications

References 244 publications

Carbapenem-Resistant Pseudomonas aeruginosa Bacteremia, through a Six-Year Infection Control Program in a Hospital

Carbapenem-Resistant Pseudomonas aeruginosa Bacteremia, through a Six-Year Infection Control Program in a Hospital

Mechanisms of Antibiotic and Biocide Resistance That Contribute to Pseudomonas aeruginosa Persistence in the Hospital Environment

Comparison of Virulence-Factor-Encoding Genes and Genotype Distribution amongst Clinical Pseudomonas aeruginosa Strains

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