Antibiotic Resistance of &lt;i&gt;Campylobacter jejuni&lt;/i&gt; and &lt;i&gt;C. coli&lt;/i&gt; Isolated from Children with Diarrhea in Thailand and Japan

Pham, Ngan Thi Kim; Thongprachum, Aksara; Tran, Dinh Nguyen; Nishimura, Shigeyuki; Shimizu-Onda, Yuko; Trinh, Quang Duy; Khamrin, Pattara; Ukarapol, Nuthapong; Kongsricharoern, Tipachan; Komine‐Aizawa, Shihoko; Okitsu, Shoko; Maneekarn, Niwat; Hayakawa, Satoshi; Ushijima, Hiroshi

doi:10.7883/yoken.jjid.2014.582

Cited by 18 publications

(12 citation statements)

References 14 publications

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“…We found two cases of bacteraemia due to Campylobacter. Very few previous studies have described Campylobacter bacteraemia in Israel or elsewhere [9][10][11] . Bacteraemia is a rare finding of Campylobacter gastroenteritis in immunocompetent children, but it has been found in several cases of immunocompromised children.…”

Section: Discussionmentioning

confidence: 99%

Campylobacter gastroenteritis in children in north-eastern Israel comparison with other common pathogens

Sakran

Hexner-Erlichman

Spiegel

et al. 2020

Sci Rep

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Gastroenteritis is common among children. Campylobacter jejuni is one of the main causative bacterial pathogens, together with Shigella, Salmonella and invasive Escherichia coli. campylobacteriosis is a zoonotic, usually self-limited disease that does not always require antibiotic treatment. In cases of protracted diarrhoea in healthy children or immunocompromised patients, antibiotic treatment is recommended, and the drug of choice is still macrolides, with very low resistance rates in Campylobacter species. However, it is crucial to isolate the causative organism, because some cases, such as Shigella encephalitis, call for initiation of empiric antibiotic treatment. In this study, we compared the incidence, epidemiology, clinical findings and laboratory results of gastroenteritis with dysentery caused by these organisms in children in our area. C. jejuni was found to be the leading pathogen in children hospitalized with bacterial gastroenteritis, followed by Shigella and Salmonella. Macrolides were the drug of choice for Campylobacter, and ceftriaxone and ciprofloxacin were the best empiric treatments for Shigella and Salmonella, respectively. Acute bacterial gastroenteritis is a common disease in infants and children. The clinical presentation includes fever, diarrhoea, bloody stool, vomiting, dehydration and abdominal pain. Campylobacter species, Shigella, Salmonella and invasive Escherichia coli are the main bacterial organisms causing acute infection in the gastrointestinal tract 1. Campylobacter organisms are thin curved Gram-negative non-spore-forming rods. The Campylobacter group includes 26 species: the most frequent types that cause disease in humans are Campylobacter jejuni, Campylobacter coli and Campylobacter fetus 2 , these are also the most common types in Israel 3. Campylobacteriosis is a zoonotic disease, with wild birds, poultry and domestic pets as the main reservoirs. Outbreaks are often linked to contaminated water, unpasteurized milk products, consumption of under-cooked chicken, environmental exposure and contact with farm animals 4. It is difficult to differentiate acute gastroenteritis caused by Campylobacter from gastroenteritis caused by Shigella or Salmonella based only on clinical signs or routine blood analysis; stool culture provides the definitive diagnosis of the causative organism. In cases of severe dehydration, toxic appearance, signs of sepsis and gastroenteritis caused by Shigella or Salmonella, initiation of empiric antibiotic treatment, such as third-generation cephalosporin, is required; in cases suspected of Shigella encephalitis, empiric treatment is also recommended. Third-generation cephalosporin has no effect against Campylobacter 4. Campylobacter is considered the causative organism in most cases of bacterial gastroenteritis in young children. It is usually a self-limited disease and does not always require antibiotic treatment. In cases of protracted diarrhoea in healthy children, or infection in immunocompromised patients, antibiotic treatment is recommended, and ...

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Section: Discussionmentioning

confidence: 99%

Campylobacter gastroenteritis in children in north-eastern Israel comparison with other common pathogens

Sakran

Hexner-Erlichman

Spiegel

et al. 2020

Sci Rep

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“…Clinical and agricultural prescription of broad‐spectrum antibiotics such as quinolones varies worldwide. Since the late 1990s, the agricultural use of fluoroquinolones has declined following governmental intervention in Europe and North America (Chang, Wang, Regev‐Yochay, Lipsitch, & Hanage, ; Nelson, Chiller, Powers, & Angulo, ); however, resistant isolates remain common and the level of resistance can vary from country to country (Pham et al., ). Higher levels of fluoroquinolone resistance have been observed among isolates from infected individuals who have recently returned from foreign travel (Gaudreau, Boucher, Gilbert, & Bekal, ).…”

Section: Discussionmentioning

confidence: 99%

Local genes for local bacteria: Evidence of allopatry in the genomes of transatlantic Campylobacter populations

et al. 2017

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The genetic structure of bacterial populations can be related to geographical locations of isolation. In some species, there is a strong correlation between geographical distance and genetic distance, which can be caused by different evolutionary mechanisms. Patterns of ancient admixture in Helicobacter pylori can be reconstructed in concordance with past human migration, whereas in Mycobacterium tuberculosis it is the lack of recombination that causes allopatric clusters. In Campylobacter, analyses of genomic data and molecular typing have been successful in determining the reservoir host species, but not geographical origin. We investigated biogeographical variation in highly recombining genes to determine the extent of clustering between genomes from geographically distinct Campylobacter populations. Whole‐genome sequences from 294 Campylobacter isolates from North America and the UK were analysed. Isolates from within the same country shared more recently recombined DNA than isolates from different countries. Using 15 UK/American closely matched pairs of isolates that shared ancestors, we identify regions that have frequently and recently recombined to test their correlation with geographical origin. The seven genes that demonstrated the greatest clustering by geography were used in an attribution model to infer geographical origin which was tested using a further 383 UK clinical isolates to detect signatures of recent foreign travel. Patient records indicated that in 46 cases, travel abroad had occurred <2 weeks prior to sampling, and genomic analysis identified that 34 (74%) of these isolates were of a non‐UK origin. Identification of biogeographical markers in Campylobacter genomes will contribute to improved source attribution of clinical Campylobacter infection and inform intervention strategies to reduce campylobacteriosis.

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“…Clinical and agricultural prescription of broad-spectrum antibiotics such as quinolones varies worldwide. Since the late 1990s, the agricultural use of fluoroquinolones has declined following governmental intervention in Europe and North America (Chang et al, 2015, Nelson et al, 2007; however, resistant isolates remain common and the level of resistance can vary from country to country (Pham et al, 2016). Higher levels of fluoroquinolone resistance have been observed among isolates from infected individuals who have recently returned from foreign travel (Gaudreau et al, 2014).…”

Section: (A) (B)mentioning

confidence: 99%

Local genes for local bacteria: evidence of allopatry in the genomes of transatlantic Campylobacter populations

Pascoe

Méric

Yahara

et al. 2016

Preprint

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35The genetic structure of bacterial populations can be related to geographical locations of 36 isolation. In some species, there is a strong correlation between geographical distance and 37 genetic distance, which can be caused by different evolutionary mechanisms. Patterns of 38 ancient admixture in Helicobacter pylori can be reconstructed in concordance with past 39 human migration, whereas in Mycobacterium tuberculosis it is the lack of recombination that 40 causes allopatric clusters. In Campylobacter, analyses of genomic data and molecular typing 41 have been successful in determining the reservoir host species, but not geographical origin. 42We investigated biogeographical variation in highly recombining genes to determine the

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Antibiotic Resistance of <i>Campylobacter jejuni</i> and <i>C. coli</i> Isolated from Children with Diarrhea in Thailand and Japan

Cited by 18 publications

References 14 publications

Campylobacter gastroenteritis in children in north-eastern Israel comparison with other common pathogens

Campylobacter gastroenteritis in children in north-eastern Israel comparison with other common pathogens

Local genes for local bacteria: Evidence of allopatry in the genomes of transatlantic Campylobacter populations

Local genes for local bacteria: evidence of allopatry in the genomes of transatlantic Campylobacter populations

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