Antibiotic resistance of Streptococcus pneumoniae in children with acute otitis media treatment failure

Zielnik-Jurkiewicz, Beata; Bielicka, Anna

doi:10.1016/j.ijporl.2015.09.030

Cited by 39 publications

(35 citation statements)

References 36 publications

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“…Our result is lower than many other studies. There are several explanations for this difference: 1) our study like some other studies was performed only among healthy children (20,21); It has been shown that during episodes of respiratory illness, in particular otitis media, nasopharyngeal flora remarkably increases (7,22), so the exclusion of sick children may result in a lower carriage rate, 2) Season may also be an important factor, so that studies in the different season may give different results (9,15). In this survey, children were sampled during a very short period of time, from midautumn until mid-spring, in contrast to most studies, in which sampling was performed in different seasons, 3) We studied a very large number of children, which is probably representative of the all age groups in contrast to most previous studies, which covered only selected groups of children or small samples, so our results can unquestionably be generalized (23)(24)(25), and 4) In our study in addition to above mentioned reasons the Iranian genetic traits might also play some role.…”

Section: Discussionmentioning

confidence: 94%

Breastfeeding and Nasopharyngeal Colonization With Common Respiratory Pathogens Among Children

et al. 2015

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Background: Breastfeeding has been associated with decreased frequency of otitis media in children. It might be due to lower prevalence of nasopharyngeal colonization with the respiratory pathogens among breast-fed infants compared to those who are formula-fed. Objectives: This study was performed to determine the influence of breastfeeding on Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis colonization rates in children. Patients and Methods: In this cross-sectional study, 2-6 years old children in 10 randomly selected daycare centers in northeast of Iran (Mashhad) were studied. We obtained nasopharyngeal specimens to culture for Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis from 1125 children. Carriage rates for aforementioned bacteria were determined and analyzed on the basis of feeding type during infancy. Results: A total of 885 children were breast-fed (78.7%), 69 children were formula-fed (6.1%), and 171 children were mixed-fed (15.2%). Carriage rates of S. pneumoniae, H. influenzae and M. catarrhalis among children were 13.1%, 9.1%, and 4.3%, respectively. Although lower incidence of nasopharyngeal colonization was found in breast-versus formula-fed children, it was not significant (P > 0.5). Conclusions: It seems that feeding in infancy has no influence over the prevalence of nasopharyngeal colonization with respiratory pathogens during childhood.

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Section: Discussionmentioning

confidence: 94%

Breastfeeding and Nasopharyngeal Colonization With Common Respiratory Pathogens Among Children

et al. 2015

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“…In addition to being the most common reason for doctor's office visits among children, AOM is also currently the most common reason for antibiotic use in the pediatric population. Recent studies have shown antibiotic resistance and decreased sensitivity developing among the major otopathogens (Pichichero, 2000a;Zielnik-Jurkiewicz and Bielicka, 2015;Sillanpaa et al, 2016;Korona-Glowniak et al, 2018). Further, the polymicrobial biofilms associated with AOM are incredibly resistant and difficult to treat using classic antibiotic protocols (Pichichero, 2000b;Leibovitz et al, 2003;Libson et al, 2005;Asher et al, 2008;Leibovitz, 2008;Korona-Glowniak et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Moraxella catarrhalis Promotes Stable Polymicrobial Biofilms With the Major Otopathogens

Bair

Campagnari

2020

Front. Microbiol.

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Otitis media (OM) is a prevalent pediatric infection characterized by painful inflammation of the middle ear. The Gram-negative diplococcus Moraxella catarrhalis is a commensal of the nasopharynx and one of three leading causative agents of OM. The most recent work on this multifaceted disease indicates that biofilms and polymicrobial infections play a pivotal role in recurrent and chronic OM, which are difficult to eradicate using standard antibiotic protocols. Although there have been significant advances in OM research, the actual bacterial and viral interactions leading to pathogenesis remain largely uncharacterized. However, colonization and persistence in the nasopharynx is clearly an essential first step. In this study, we assessed the role M. catarrhalis plays in the co-colonization and persistence of the other major otopathogens, Streptococcus pneumoniae and non-typeable Haemophilus influenzae (NTHi). We characterized both monomicrobial and polymicrobial biofilms using an in vitro nasopharyngeal colonization model. Biofilm assays were designed to mimic the nasopharynx and bacterial persistence was quantified over time. NTHi showed a steady and significant decline in viability over 20-48 h when this organism was in a dual species biofilm with S. pneumoniae. However, when M. catarrhalis was present in the polymicrobial biofilm NTHi survived for 48 h at 10 7 CFU per mL. In addition, an isogenic M. catarrhalis catalase-deficient mutant was also fully capable of protecting NTHi from the bactericidal activity of S. pneumoniae in a polymicrobial biofilm. Our results show that M. catarrhalis promotes a favorable environment for stable polymicrobial biofilms by enhancing the survival of NTHi in the presence of S. pneumoniae. These data suggest that colonization with M. catarrhalis promotes stable co-colonization with other otopathogens.

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“…Moreover, the widespread use of systemic antibiotics for a disease of such high prevalence is believed to be responsible, at least in part, for the ongoing increase in antibiotic resistance among nasopharyngeal pathobionts (13). Drug resistance can also result from incomplete adherence to the current multidose, multiday regimens, which is common, especially in young children (14). According to the Centers for Disease Control and Prevention (CDC), 23,000 death and 2 million illnesses in the US are associated with antibiotic-resistant infections, which are difficult to treat (15).…”

Section: Introductionmentioning

confidence: 99%

Treatment of Streptococcus pneumoniae otitis media in a chinchilla model by transtympanic delivery of antibiotics

Yang¹,

Sabharwal²,

Shlykova³

et al. 2018

JCI Insight

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Antibiotic resistance of Streptococcus pneumoniae in children with acute otitis media treatment failure

Cited by 39 publications

References 36 publications

Breastfeeding and Nasopharyngeal Colonization With Common Respiratory Pathogens Among Children

Breastfeeding and Nasopharyngeal Colonization With Common Respiratory Pathogens Among Children

Moraxella catarrhalis Promotes Stable Polymicrobial Biofilms With the Major Otopathogens

Treatment of Streptococcus pneumoniae otitis media in a chinchilla model by transtympanic delivery of antibiotics

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