Antibiotic resistance patterns in coagulase-negative staphylococci after treatment with topical erythromycin, benzoyl peroxide, and combination therapy

Abstract

Antibiotic resistance of the resident cutaneous bacterial flora is a well recognized consequence of systemic antibiotic therapy. In this study, we followed the development of antibiotic resistance of coaguiase-negative staphylococci (CNS), the most numerous aerobic bacteria found on the skin surface, during treatment with three topical antimicrobial agents used to treat acne vulgaris. Groups of 20 subjects received either topical erythromycin, benzoyi peroxide or a combination of the two for 16 weeks. After 12 weeks of treatment with erythromycin, the aerobic flora was dominated by S. epkiennidis which was completely resistant to erythromycin. In addition there was an increase in resistance to clindamycin and tetracycline. Treatment with benzoyi peroxide and the combination of erythromycin and benzoyi peroxide resulted in a significant reduction in the number of aerobic bacteria without any change in the resistance pattern to erythromycin or other antibiotics.

Guidelines of care for acne vulgaris management

“…Bacterial cultures, including antibacterial sensitivities, are usually of value in establishing the diagnosis and in determining therapy. [16][17][18][19] Endocrinologic testing Table III shows the recommendations for endocrinologic testing.…”

Topical clindamycin in the management of acne vulgaris

“…Overall, clindamycin resistance occurred in 11 of 48 (23%) CNS isolates pre-therapy and 23 of 29 (79%) CNS isolates post-therapy. Hence, previous macrolide therapy can induce not just macrolide resistance but also clindamycin resistance [35] .…”

Rhodomyrtone from Rhodomyrtus tomentosa (Aiton) Hassk. as a Natural Antibiotic for Staphylococcal Cutaneous Infections

“…After 12 weeks of treatment with erythromycin, S. epidermidis was found to become completely resistant and there was an increase in resistance to clindamycin and tetracycline. 26) After long-term systemic antibiotic therapy, the resistant strains of S. epidermidis increased. 10) The prevalence of erythromycin-resistant coagulase-negative staphylococci increased to 98% by week 12.…”