Antibiotic Resistance Profile and Detection in ESKAPE Pathogens

Agrawal, Ankita; Patel, Amiya Kumar

doi:10.1007/978-981-99-8799-3_2

ESKAPE Pathogens 2024

DOI: 10.1007/978-981-99-8799-3_2

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Antibiotic Resistance Profile and Detection in ESKAPE Pathogens

Ankita Agrawal,

Amiya Kumar Patel

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2024

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Cited by 4 publications

References 178 publications

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Comprehensive Assessment of Antioxidant, Antimicrobial, and Cytotoxic Activities of Schiff Bases Synthesized from Phenyl Glyoxal: Insights from Molecular Docking and ADMET Analysis

Tomer,

Bansal,

Vats

et al. 2024

ChemistrySelect

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In this study, novel Schiff base, PTIEO and PABHP were synthesized using Phenyl Glyoxal as a major constituent and their structures were elucidated through modern spectroscopic techniques. Antioxidant assays were performed using DPPH and ABTS assays. Further, PTIEO and PABHP were subjected to in vitro biological evaluations against ESKAP pathogens. This investigation revealed significant antibacterial activity of both compounds, with MIC below 64 μg mL−1 against Staphylococcus aureus and 64 μg mL−1 against Acinetobacter baummanii. In molecular docking studies, PTIEO shows enhanced binding energy with Acinetobacter baumannii bacterial protein Diaminopimelate epimerase at −7.45 Kcal mol−1, while PABHP exhibited −8.32 Kcal mol−1 binding energy with NADH‐dependent enoyl‐ACP reductase. Additionally, PTIEO and PABHP demonstrated good binding energy with Sortase‐A of Staphylococcus aureus at −7.59 Kcal mol−1 and −8.75 Kcal mol−1, respectively. Moreover, antifungal capabilities of these compounds were evaluated against pathogenic fungi Candida Albicans, Candida Parapsilosis, and Candida tropicalis, highlighting their broad‐spectrum antimicrobial properties. Moreover, PABHP displayed cytotoxicity with an IC50 value of 23.50 μg mL−1, suggesting its safer administration. ADMET calculations were also performed to demonstrate their effectiveness. Overall, these experiments attribute to the significant therapeutic behavior of Schiff bases as comprehensive biomedical agents.

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Comprehensive Assessment of Antioxidant, Antimicrobial, and Cytotoxic Activities of Schiff Bases Synthesized from Phenyl Glyoxal: Insights from Molecular Docking and ADMET Analysis

Tomer,

Bansal,

Vats

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

show abstract

Effect of amikacin-humic acid combination on Acinetobacter baumannii biofilm: an in vitro and in silico study

Rajangam,

Leela,

Jayaraman

et al. 2024

Future Microbiology

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A New Insight into Phage Combination Therapeutic Approaches Against Drug-Resistant Mixed Bacterial Infections

Rahimian,

Jafari-Gharabaghlou,

Mohammadi

et al. 2024

PHAGE

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Antibiotic Resistance Profile and Detection in ESKAPE Pathogens

Cited by 4 publications

References 178 publications

Comprehensive Assessment of Antioxidant, Antimicrobial, and Cytotoxic Activities of Schiff Bases Synthesized from Phenyl Glyoxal: Insights from Molecular Docking and ADMET Analysis

Comprehensive Assessment of Antioxidant, Antimicrobial, and Cytotoxic Activities of Schiff Bases Synthesized from Phenyl Glyoxal: Insights from Molecular Docking and ADMET Analysis

Effect of amikacin-humic acid combination on Acinetobacter baumannii biofilm: an in vitro and in silico study

A New Insight into Phage Combination Therapeutic Approaches Against Drug-Resistant Mixed Bacterial Infections

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