One of the vital principle for preventing Ventilator Associated Pneumonia (VAP) in the hospital is equipping healthcare worker by adequate knowledge regarding VAP prevention measures. Integration of electronic education into nursing education lowing growing awareness all-over the world help Intense Care Unit (ICU) nurses to incorporate evidence based practice into daily care for critically ill patient. Study aimed to evaluate the effectiveness of electronic learning module in implementation of ventilatorassociated-pneumonia prevention measures among intensive care unit nurses. Quasi experimental design was used. The current study was conducted in intensive care unit of Al Noor Specialist Hospital in Makkah. Convenience sample of 109 ICU nurses was recruited. This study was conducted by using two tools; knowledge assessment tool and VAP bundle checklist . It was founded that nurses' knowledge before they were exposed to educational module was graded as average 72.66% while scores were improved after the exposure to learning module to be high 96.2% meaning that their knowledge has been noticeably improved. However, differences in ICU nurses knowledge in pre and post test was highly signi icant (p < 0.005). ICU nurses poor performance was apparent before exposure to module (61.73%), while ICU nurses performance showed tremendous improvement ( >99%) in the last observation. The difference between preand post test observation was highly signi icant (p > 0.005). The study revealed that e-learning module in educating ICU nurses about VAP prevention were considerably effective. This was highlighted by high mean scores for VAP knowledge and practice after exposure to module. Recommendation: Integrate orientation program for VAP prevention measures to new staff and continues professional development program for senior staff.