Antibiotic resistance properties of uropathogenic &lt;i&gt;Escherichia coli&lt;/i&gt; isolated from pregnant women with history of recurrent urinary tract infections

Habibi, Asghar; Khameneie, Maryam Khayyat

doi:10.4314/tjpr.v15i8.21

Cited by 11 publications

(7 citation statements)

References 19 publications

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“…High urinary levels of levofloxacin are not enough to cure UTIs and the combination of ceftolozane/tazobactam was more effective as an alternative treatment in settings of increased fluoroquinolone resistance (Huntington et al, 2016 ). Increased resistance of UPEC strain isolates against ampicillin (96.42 %), tetracycline (85.71 %), amikacin (71.42 %), ciprofloxacin (67.85 %), and gentamycin (58.71 %) has been found in pregnant women with history of recurrent UTIs (Habibi and Khameneie, 2016 ). Finally, numerous government agencies advise against the long-term use of prophylactic nitrofurantoin because of rare but serious pulmonary and hepatic adverse effects (Vahlensieck et al, 2016 ).…”

Section: Upec Antibiotic Susceptibility and Resistancementioning

confidence: 99%

UroPathogenic Escherichia coli (UPEC) Infections: Virulence Factors, Bladder Responses, Antibiotic, and Non-antibiotic Antimicrobial Strategies

2017

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Urinary tract infections (UTIs) are one of the most common pathological conditions in both community and hospital settings. It has been estimated that about 150 million people worldwide develop UTI each year, with high social costs in terms of hospitalizations and medical expenses. Among the common uropathogens associated to UTIs development, UroPathogenic Escherichia coli (UPEC) is the primary cause. UPEC strains possess a plethora of both structural (as fimbriae, pili, curli, flagella) and secreted (toxins, iron-acquisition systems) virulence factors that contribute to their capacity to cause disease, although the ability to adhere to host epithelial cells in the urinary tract represents the most important determinant of pathogenicity. On the opposite side, the bladder epithelium shows a multifaceted array of host defenses including the urine flow and the secretion of antimicrobial substances, which represent useful tools to counteract bacterial infections. The fascinating and intricate dynamics between these players determine a complex interaction system that needs to be revealed. This review will focus on the most relevant components of UPEC arsenal of pathogenicity together with the major host responses to infection, the current approved treatment and the emergence of resistant UPEC strains, the vaccine strategies, the natural antimicrobial compounds along with innovative anti-adhesive and prophylactic approaches to prevent UTIs.

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Section: Upec Antibiotic Susceptibility and Resistancementioning

confidence: 99%

UroPathogenic Escherichia coli (UPEC) Infections: Virulence Factors, Bladder Responses, Antibiotic, and Non-antibiotic Antimicrobial Strategies

2017

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“…In addition, most isolated gram-negative bacteria are sensitive to gentamicin, ceftazidime, and ciprofloxacin whereas these bacteria are resistant to ampicillin, chloramphenicol, and amoxycillin. 32,33 CoNS are sensitive to a wide range of antimicrobials but are resistant to benzylpenicillin and oxacillin. Taponen et al 34 found that penicillin resistance was the most common type of antimicrobial resistance in CoNS, and Staphylococcus epidermidis was the most resistant among the four major species.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Spectrum of uropathogens and their susceptibility to antimicrobials in pregnant women: a retrospective analysis of 5-year hospital data

et al. 2021

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Objective Urinary tract infections (UTI) are common during pregnancy. Identification of antimicrobial susceptibility patterns of microorganisms in pregnant women is important to select the most appropriate antimicrobial. We assessed common uropathogens in pregnant women with UTI and antimicrobial susceptibility, to guide empirical antibiotic selection. Methods In this retrospective study, we analyzed mid-stream urine culture and antibiotic susceptibility data from pregnant women who attended Jordan University Hospital during 2014 to 2018. Data were collected from patients’ charts and urine cultures, and sensitivity results were extracted from the laboratory electronic system. We calculated descriptive statistics and determined correlations among pathogens and antibiotics. Results We examined 612 positive urine cultures from 559 pregnant women, including 163 (29.2%) inpatients. Escherichia coli (29.4%) was the most frequently identified microorganism, followed by coagulase-negative staphylococci (CoNS) (21.6%). All bacterial isolates were sensitive to aztreonam, chloramphenicol, fosfomycin, ofloxacin, pefloxacin, piperacillin, and colistin sulfate; 87.5% were sensitive to amikacin. Only 15.79%, 18.93%, and 17.91% were sensitive to oxacillin, nalidixic acid, and erythromycin, respectively. Conclusion E. coli and CoNS were the most commonly identified microorganisms in this study. We found increased antibiotic resistance in Enterobacter species. The chosen antimicrobial therapy in pregnancy should be determined by sensitivity/resistance and fetomaternal safety.

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“…[ 8 ] Moreover, UPEC isolates from pregnant women who have a history of recurrent UTIs have shown a significant increase in resistance to tetracycline, ampicillin, ciprofloxacin, gentamycin, and amikacin. [ 13 ] The prevalence of resistance among UPEC in Europe constitutes 11.8% for the third-generation cephalosporins and 22.3% for fluoroquinolones. In the United States, the prevalence of fluoroquinolone-resistant UPEC in hospitals constituted 31.3% for the period 2007–2010.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Medicinal Plants against Uropathogenic Escherichia coli

Marouf

Arsène

Ermolaev

et al. 2022

Journal of Pharmacy and Bioallied Sciences

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Urinary tract infections (UTIs) are one of the most common bacterial infections with uropathogenic Escherichia coli (UPEC) being the most prevalent causative agent in both complicated and uncomplicated UTIs. Antibiotic resistance among UPEC has been already demonstrated against a wide variety of antibiotics and the situation is continuing to deteriorate increasing the rate of recurrence and the difficulty of treatment and prophylaxis. Recently, a big attention has been paid to non-antibiotic approaches as an alternative to conventional antibiotics. Among many strategies, phytotherapy has gained a special attention worldwide. Herbal remedies have been used in traditional medicine since ancient times and they are well known for their effectiveness in treating many health conditions including UTIs. Researches are conducted continuously to validate the use of many medicinal plants against UPEC, investigate their mechanisms of action, and determine their active constituents. Our extensive review of the recent literature revealed that many phytochemicals are shown to target and inhibit a wide variety of bioprocesses in UPEC, such as adhesion, motility, biofilm formation, and quorum sensing. Such natural approaches are very promising in confronting the antibiotic resistance of UPEC and can be further used to develop plant-based strategies and pharmaceutical products to treat and prevent UTIs caused by UPEC.

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Antibiotic resistance properties of uropathogenic <i>Escherichia coli</i> isolated from pregnant women with history of recurrent urinary tract infections

Cited by 11 publications

References 19 publications

UroPathogenic Escherichia coli (UPEC) Infections: Virulence Factors, Bladder Responses, Antibiotic, and Non-antibiotic Antimicrobial Strategies

UroPathogenic Escherichia coli (UPEC) Infections: Virulence Factors, Bladder Responses, Antibiotic, and Non-antibiotic Antimicrobial Strategies

Spectrum of uropathogens and their susceptibility to antimicrobials in pregnant women: a retrospective analysis of 5-year hospital data

Antibacterial Activity of Medicinal Plants against Uropathogenic Escherichia coli

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