Antibiotic Resistance Trends and The ESBL Prevalence of Escherichia coli and Klebsiella spp Urinary Isolates in In-and Outpatients in a Tertiary Care Hospital in Istanbul, 2004 - 2012

Şenbayrak, Seniha; Boz, Efe Serkan; Cevan, Simin; İnan, Asuman; Engin, Derya Öztürk; Dosoglu, Nilgun; Cobanoglu, Naz; Dagli, Ozgur; Davarcı, İsmail; Aksaray, Sebahat

doi:10.5812/jjm.13098

Cited by 7 publications

(6 citation statements)

References 25 publications

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“…[35][36][37] . In contrast, several studies reported the highest ESBL production among K. pneumoniae followed by E. coli which do not match our results [38][39][40] , since we found E. coli as the predominant ESBL producer.…”

Section: Percent Of Sensiɵvitycontrasting

confidence: 99%

Comprehensive study of antimicrobial susceptibility pattern and extended spectrum beta-lactamase (ESBL) prevalence in bacteria isolated from urine samples

Gharavi

Zarei

Roshani-Asl

et al. 2021

Sci Rep

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Nowadays, increasing extended-spectrum β-lactamase (ESBL)-producing bacteria have become a global concern because of inducing resistance toward most of the antimicrobial classes and making the treatment difficult. In order to achieve an appropriate treatment option, identification of the prevalent species which generate ESBL as well as their antibiotic susceptibility pattern is essential worldwide. Hence, this study aimed to investigate the prevalence of ESBL-producing bacteria and assess their drug susceptibility in Fardis Town, Iran. A total of 21,604 urine samples collected from patients suspected to have urinary tract infection (UTI) were processed in the current study. The antimicrobial susceptibility of the isolates was tested by the disk diffusion method. The ESBL producing bacteria were determined by Double Disc Synergy Test (DDST) procedure. Bacterial growth was detected in 1408 (6.52%) cases. The most common bacterial strains causing UTI were found E. coli (72.16%), followed by K. pneumoniae (10.3%) and S. agalactiae (5.7%). Overall, 398 (28.26%) were ESBL producer. The highest ESBL production was observed in E. coli, followed by Klebsiella species. ESBL producers revealed a higher level of antibiotic resistance compared with non-ESBLs. In conclusion, ESBL production in uropathogens was relatively high. Carbapenems and Aminoglycosides were confirmed as the most effective treatment options for these bacteria.

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Section: Percent Of Sensiɵvitycontrasting

confidence: 99%

Comprehensive study of antimicrobial susceptibility pattern and extended spectrum beta-lactamase (ESBL) prevalence in bacteria isolated from urine samples

Gharavi

Zarei

Roshani-Asl

et al. 2021

Sci Rep

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“…The current results are in agreement with earlier study that only 35.6% of isolates were from men patients (Bakshi, et al, 2019). Other research has been shown that ESBL-producing E. coli incidences were significantly higher in females 73.6% than males 26.4% (Senbayrak, et al, 2017). It has been revealed that the high UTI prevalence in female can be attributed to many factors such as anatomical differing that allow quick admission of bacteria to the urinary tract (Rowe and Juthani-Mehta, 2013;Foad, 2016).…”

Section: Discussionsupporting

confidence: 92%

“…According to an Iranian investigation, ESBL production was identified in 40.8% of all the isolates tested (Seyedjavadi, Goudarzi and Sabzehali, 2016), whereas other study reported 42.5% of the isolates recovered from outpatients (Koshesh, et al, 2016). Another investigation from tertiary care hospital in Istanbul revealed that 44.7% and 22.8% of isolates were ESBL enzyme producer among inpatients and outpatients, respectively (Senbayrak, et al, 2017). Based on the results of this study, the number of isolates that were found to be positive for AmpC screening were 27 (38.6%) which is in accordance to the previous published studies.…”

Section: Discussionmentioning

confidence: 97%

The Coexistence of extended spectrum β lactamases and AmpC production among uropathogenic isolates of Escherichia coli and its antibiogram pattern

Ganjo

2022

ARO

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Emergence of drug resistance in Escherichia coli due to various mechanisms makes the treatment choices very limited. The objective of this research was to investigate extended-spectrum beta-lactamases (ESBLs) and AmpC lactamases in E. coli isolates from urinary tract infections (UTIs) and to assess their antibacterial susceptibility patterns in a health-care context. A total of 70 E. coli isolates from clinically assumed cases of UTI patients during the 9 months period. The isolates with bacteriuria (105 CFU/ml) were identified. ESBL and AmpC were detected phenotypically. Out of the 70 isolates of uropathogenic E. coli, ESBL production was detected in 34 (48.6%) isolates and AmpC producer in 27 (38.6%) of isolates in which 14 (20%) of them showed coexistence phenotype of both ESBLs and AmpC and 23 (32.9%) E. coli isolates were both ESBL and AmpC non-producer. The findings donated information regarding drug resistance. The level of resistance recorded in ESBL- and AmpC-producing uropathogenic E. coli of this study was raising; therefore, it is crucial to have a strict infection control measures and routine monitoring of ESBL- and AmpC-producing bacteria in clinical laboratory.

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“…A study on examining the ESBL prevalence of E. coli isolated from urine samples of patients. The results of the study demonstrated that the prevalence of ESBL producers was a significant increase among isolates from inpatients (12.5 % to 44.7 %) and from outpatients (9.6 % to 22.8 %) (41). In 2012, 66 (37.1 %) of a total of 178 patients were ESBL positive-E. coli isolated from urine samples (n= 322) collected from Ankara Training and Research Hospital in Ankara province of Turkey (27).…”

Section: Discussionmentioning

confidence: 90%

Determination of antibiotic susceptibility, ESBL genes and pulsed-field gel electrophoresis profiles of extended-spectrum β-lactamase-containing Escherichia coli isolates

Tutun¹,

Karagöz²,

Altıntaş³

et al. 2019

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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The purpose of this study was to determine the phenotypic antibiotic susceptibility patterns, extended-spectrum βlactamase (ESBL) genes and genotypic profiles of ESBL-positive Escherichia coli strains isolated from urine samples obtained from outpatients with urinary tract infection in Turkey. A total of 120 E. coli strains during 2017, 2018, and 2019 (40 patients per year) were examined for antibiotic susceptibility patterns by disc diffusion method, for ESBL genes using PCR and sequencing and for molecular typing by pulsed-field gel electrophoresis (PFGE) method. The isolates were evaluated for their sensitivity to 21 different antibiotics. Four different antimicrobial resistance patterns were determined according to antibiotic susceptibility status of the isolates. The βlactamase genes detected in the isolates were CTX-M-15 + OXA-1 (n= 14), CTX-M-15 (n= 24), TEM-1 + CTX-M-15 (n= 52), TEM-1 + SHV-12 (n=6), SHV-12 1 (n= 6), TEM-1 + CTX-M-1 (n= 6), TEM-1 + CTX-M-16 (n= 6) and TEM-1 + CTX-M-9 (n= 6). The CTX-M-15 was the most prevalent ESBL enzyme in the isolates. As a result of PFGE analysis performed by XbaI enzyme restriction process, one major PFGE profile and three main groups (Group I-II-III) were observed. While antibiotic resistance profiles of the strains showed four groups (RI-RII-RIII-RIV), PFGE band profiles showed a major group (90% similarity ratio). High ESBL production and decreased susceptibility to broad-spectrum cephalosporins were observed in E. coli strains. In addition, PFGE analysis showed high clonal similarity among E. coli isolates.

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Antibiotic Resistance Trends and The ESBL Prevalence of Escherichia coli and Klebsiella spp Urinary Isolates in In-and Outpatients in a Tertiary Care Hospital in Istanbul, 2004 - 2012

Abstract: Background: Extended spectrum beta-lactamase (ESBL) producing organisms causing urinary tract infections are increasing in incidence and becoming a serious health problem due to their resistance to large number of antibiotics.

Cited by 7 publications

References 25 publications

Comprehensive study of antimicrobial susceptibility pattern and extended spectrum beta-lactamase (ESBL) prevalence in bacteria isolated from urine samples

Comprehensive study of antimicrobial susceptibility pattern and extended spectrum beta-lactamase (ESBL) prevalence in bacteria isolated from urine samples

The Coexistence of extended spectrum β lactamases and AmpC production among uropathogenic isolates of Escherichia coli and its antibiogram pattern

Determination of antibiotic susceptibility, ESBL genes and pulsed-field gel electrophoresis profiles of extended-spectrum β-lactamase-containing Escherichia coli isolates

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