Antibiotic-Resistant Escherichia coli and Salmonella from the Feces of Food Animals in the East Province of Rwanda

Manishimwe, Rosine; Moncada, Paola M.; Musanayire, Vestine; Shyaka, Anselme; Scott, H. M.; Loneragan, Guy H.

doi:10.3390/ani11041013

Cited by 17 publications

(13 citation statements)

References 51 publications

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“…A similar study conducted in Qatar reported relatively high resistance of E. coli isolates recovered from the feces of healthy goats to TEs (34%) [58]. In contrast, Manishimwe et al [59] and Srivani et al [60] reported lower levels of resistance to AMP and TE, with proportions of 7.4% and 14.1%, respectively. In addition, E. coli resistance to CIP (4.7%) has been reported [60].…”

Section: Discussionmentioning

confidence: 90%

Antimicrobial resistance profiles of Escherichia coli derived from an integrated agroforestry-livestock system in Deli Serdang Regency, Indonesia

Dewi,

Nuryawan,

Jajere

et al. 2024

Vet World

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Background and Aim: Antimicrobial resistance (AMR) has become a significant global concern. Epidemiological data do not provide a robust description of the potential risks associated with AMR in the integrated agroforestry-livestock systems in Indonesia. Thus, the present study investigated the phenotypic and multidrug resistance (MDR) profiles of Escherichia coli strains isolated from the feces of livestock raised in the agro-silvopastoral system in Deli Serdang Regency, North Sumatra Province. Materials and Methods: A standard microbiological culture procedure was followed to isolate the organism and test antibiotic susceptibility using the Kirby-Bauer disk diffusion protocol. Furthermore, the multiple antibiotic resistance index was determined. Univariate analysis was conducted to identify the risk factors associated with AMR. Results: The vast majority (77.5%) of livestock farmers were aged >30 years. All farmers were men and had no higher education (100% of them). The majority of the animal species managed were cattle and goats (37.5% each) and the livestock grazing pasture system (67.5%). In addition, the majority of farmers reported high antimicrobial use on their farms (87.5%). Of the samples (n = 142) analyzed, n = 70 were positive, with an overall prevalence of 44.4%. The species-specific prevalences of E. coli were 32.5%, 47.8%, and 50% in buffalo, goat, and cattle, respectively. Ampicillin and tetracyclines exhibited high resistance levels among the studied animal species. A relatively lower MDR for E. coli was associated with grazing on the pasture. Conclusion: The findings from the current study provide baseline epidemiological information for future robust studies aimed at elucidating the drivers and patterns of AMR in agro-silvopastoral systems in the study area or elsewhere. Keywords: agro-silvopastoral, antimicrobial Resistance, Escherichia coli,Indonesia, livestock, multidrug resistance.

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Section: Discussionmentioning

confidence: 90%

Antimicrobial resistance profiles of Escherichia coli derived from an integrated agroforestry-livestock system in Deli Serdang Regency, Indonesia

Dewi,

Nuryawan,

Jajere

et al. 2024

Vet World

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“…For instance, some African countries explained that tetracycline is the major class of antibiotic used in animals because of its low cost [ 23 ]. The elevated consumption of tetracycline in food animals can also be related to the high level of prevalence of bacteria resistant to tetracycline reported in different food-producing animals in Rwanda [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Importation trends in antibiotics for veterinary use in Rwanda: A retrospective study between 2019 and 2021

Manishimwe,

Ndayisenga,

Habimana

et al. 2024

PLoS ONE

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Estimating antibiotic consumption in animals is fundamental to guiding decision-making and research on controlling the emergence and spread of antibiotic-resistant bacteria in humans, animals, and the environment. This study aimed to establish importation trends of antibiotics for veterinary use in Rwanda between 2019 and 2021. Data was collected from the Rwanda Food and Drugs Authority’s database. Quantities of imported antibiotic active ingredients were computed using the information extracted from the issued import licenses. These quantities were subsequently adjusted per animal biomass. In total, 35,291.4 kg of antibiotics were imported into Rwanda between 2019 and 2021, with an annual mean of 11,763.8 ± 1,486.9 kg. The adjustment of imported quantities of antibiotics per animal biomass revealed that 29.1 mg/kg, 24.3 mg/kg, and 30.3 mg/kg were imported in 2019, 2020, and 2021 respectively. A slight but not statistically significant decline in antibiotic importation was noted in 2020 (p-value = 0.547). Most of the imported antibiotics were indicated to be used in food-producing animals (35,253.8 kg or 99.9% of the imported antibiotics). Tetracyclines (17,768.6 kg or 50.3%), followed by sulfonamides (7,865.0 kg or 22.3%) and aminoglycosides (4,071.1 kg or 11.5%), were the most imported antibiotics over the studied period. It was noted that 78.9% of the imported antibiotics were categorized as highly important antimicrobials for human medicine. This study established a generalized overview of the importation of antibiotics for veterinary use in Rwanda. These results can serve as guidance for the control of antibiotic misuse. They can be used to make a correlation between antibiotic importation, antibiotic consumption, and the occurrence of antibiotic resistance in the country.

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“…The elevated consumption of tetracycline in food-animal can explain the high level of prevalence of bacteria-resistant to tetracycline reported in different food-producing animals in Rwanda (29).…”

Section: Discussionmentioning

confidence: 99%

Consumption Trends in Antibiotics for Veterinary Use in Rwanda: A Retrospective Study between 2019 and 2021

Manishimwe¹,

Ndayisenga²,

Habimana³

et al. 2022

Preprint

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Background Estimation of antibiotic consumption in animals is very important to guide decision-making and research related to the control of emergences and spread of antibiotic-resistant bacteria in humans, animals, and the environment. This study aimed at to establishing consumption trends of antibiotics for veterinary purpose in Rwanda between 2019 and 2021. Data were collected from the Rwanda Food and Drugs Authority’s database. Quantities of imported antibiotic active ingredients were computed using the information extracted from the issued import licenses. These quantities were subsequently adjusted per animal biomass. Results In total 35 291.39 kg of antibiotics were consumed in Rwanda between 2019 and 2021 with an annual mean of 11 763.80 ± 1 486.91kg. The adjustment of imported quantities of antibiotics per animal biomass revealed that 29.82mg/kg and 25.22 mg/kg were consumed in 2019 and 2020 respectively. A decline in antibiotic consumption was noted in 2020 (p-value > 0.05). Most of the imported antibiotics were indicated for food-producing animals (35 289.36 kg or 99.99% of the imported antibiotics). Tetracycline (17 768.65 kg), followed by sulfonamides (7 864.99 kg) and aminoglycosides (4 071.12 kg) were the most imported antibiotics over the studied period. It was noted that 78.93% of the imported antibiotics were categorized as highly important antimicrobials for human medicine. Conclusion This study establishes a generalized overview of the consumption of antibiotics for veterinary use in Rwanda. Results can serve as guidance to control antibiotic misuse and to make correlation between antibiotic consumption and occurrence of antibiotic resistance.

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Antibiotic-Resistant Escherichia coli and Salmonella from the Feces of Food Animals in the East Province of Rwanda

Cited by 17 publications

References 51 publications

Antimicrobial resistance profiles of Escherichia coli derived from an integrated agroforestry-livestock system in Deli Serdang Regency, Indonesia

Antimicrobial resistance profiles of Escherichia coli derived from an integrated agroforestry-livestock system in Deli Serdang Regency, Indonesia

Importation trends in antibiotics for veterinary use in Rwanda: A retrospective study between 2019 and 2021

Consumption Trends in Antibiotics for Veterinary Use in Rwanda: A Retrospective Study between 2019 and 2021

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