Antibiotic-Responsive Histiocytic Ulcerative Colitis in 9 Dogs

Hostutler, Roger A.; Luria, Brian J.; Johnson, Susan E.; Weisbrode, Steven E.; Sherding, Robert G.; Jaeger, Jordan Q.; Guilford, W. Grant

doi:10.1892/0891-6640(2004)18<499:ahucid>2.0.co;2

Cited by 27 publications

(30 citation statements)

References 26 publications

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“…As demonstrated in canine case studies, 11 regression of clinical signs following antibacterial treatment in the present case suggests a critical role of E coli in feline GC. The cat responded well to intermittently administered enrofloxacin when it had semi-formed stools or diarrhoea.…”

Section: Discussionsupporting

confidence: 77%

“…1 In dogs, at least 6-8 weeks of treatment at doses of 5-10 mg/kg body weight q24h is recommended. 1 However, response to antibacterials varies among individual dogs, 1,11 and it appears that antibacterial resistance significantly affects clinical outcomes. 12 Although the current single case was insufficient to determine the factors affecting clinical outcomes in cats, a future case series would help in determining the optimal use of antibacterials in feline GC.…”

Section: Discussionmentioning

confidence: 99%

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Escherichia coli-induced granulomatous colitis in a cat

Matsumoto

Nakashima

Morita

et al. 2019

Journal of Feline Medicine and Surgery Open Reports

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Case summaryA 10-year-old castrated male domestic shorthair cat presented with a 6 month history of diarrhoea that responded poorly to medical treatment. Ultrasonography revealed moderate thickening of the colonic wall (4.8 mm) and right colic and jejunal lymphadenomegalies. Endoscopic examination revealed partial circumferential narrowing of the transverse colon and friable colonic mucosa with multiple haemorrhagic regions. Histopathological and immunohistochemical examinations revealed a large number of Escherichia coli phagocytosed by periodic acid–Schiff-positive macrophages. Bacterial culture also yielded enrofloxacin-sensitive E coli. The cat was initially treated with prednisolone, which resulted in little improvement. Following histopathological examination and bacterial culture, treatment with enrofloxacin was commenced. Antibacterial therapy resulted in remission of the diarrhoea and an increase in body weight within 14 days.Relevance and novel informationGranulomatous colitis (GC) or histiocytic ulcerative colitis has been rarely described in cats. There has only been one previously published case study involving a cat, and the aetiology remains largely unknown. The current article describes the regression of E coli-related GC following antibacterial treatment in a cat. Clinical signs, histopathological appearance and response to enrofloxacin were similar to those in canine GC. The current findings suggest that E coli also plays an important role in the development of feline GC.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Escherichia coli-induced granulomatous colitis in a cat

Matsumoto

Nakashima

Morita

et al. 2019

Journal of Feline Medicine and Surgery Open Reports

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“…This disease has also rarely been reported in other dog breeds and cats. The presence of large macrophages that are strongly periodic acid-Schiffpositive is recognized in cases of histiocytic ulcerative colitis (German et al, 2000;Hostutler et al, 2004).…”

Section: Fecal Leukocytesmentioning

confidence: 99%

Dry-Mount Fecal Cytology

Weeden¹,

Wamsley²

2016

Canine and Feline Cytology

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“…Granulomatous colitis (GC) is an infectious large intestinal disease that primarily affects young Boxers and French Bulldogs, although it has been reported in other dog breeds too. [1][2][3][4] Clinical signs associated with GC include tenesmus and frequent, small-volume diarrhoea containing frank blood or mucus. 5 Histopathologically, GC is characterized by mucosal ulceration and submucosal infiltration by a mixture of lymphocytes, neutrophils and macrophages, the latter of which are periodic acid-Schiff-positive (PAS+).…”

Section: Introductionmentioning

confidence: 99%

“…5 Histopathologically, GC is characterized by mucosal ulceration and submucosal infiltration by a mixture of lymphocytes, neutrophils and macrophages, the latter of which are periodic acid-Schiff-positive (PAS+). 2,6,7 Originally thought to be an immune mediated disease, GC was recently determined to be caused by mucosally adherent and invasive Escherichia coli. 1 Disease remission is contingent upon eradication of bacteria within PAS+ macrophages, usually achieved with a fluoroquinolone antibiotic such as enrofloxacin.…”

Section: Introductionmentioning

confidence: 99%

Escherichia coli‐associated granulomatous colitis in a cat

Safian

Bolton

2021

Vet Record Case Reports

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A six‐year‐old male castrated domestic shorthair cat was evaluated for a six‐month history of haematochezia, mucoid diarrhoea, tenesmus and rectal prolapse. Colonic histopathology revealed multifocal mucosal ulceration and lamina propria infiltration with large numbers of periodic acid‐Schiff‐positive macrophages. Large clusters of intracellular Escherichia coli were confirmed with fluorescence in situ hybridization testing, similar to that seen in dogs with granulomatous colitis. An eight‐week course of marbofloxacin resulted in resolution of clinical signs; however, recurrence occurred four weeks later. A 12‐week course of marbofloxacin resulted in disease remission for which the cat still remains free of clinical signs (15 months). Escherichia coli‐associated granulomatous colitis, although reported with rarity in this species, is an important infectious cause of chronic large intestinal disease in the cat.

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Antibiotic-Responsive Histiocytic Ulcerative Colitis in 9 Dogs

Cited by 27 publications

References 26 publications

Escherichia coli-induced granulomatous colitis in a cat

Escherichia coli-induced granulomatous colitis in a cat

Dry-Mount Fecal Cytology

Escherichia coli‐associated granulomatous colitis in a cat

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