Antibiotic sensitivity and resistance in children with urinary tract infection in Sanliurfa

Abstract

Objective: This study aimed to evaluate antibiotic resistance in the province of Şanliurfa and to observe any difference between antibiotic resistance rates. Material and methods:The study comprised 107 children who presented at the pediatric polyclinic with complaints of urinary tract infection with the diagnosis of urinary tract infection and whose urine cultures exhibited bacterial growth. The patients were analyzed with respect to the frequency of proliferating pathogens, sensitivity to the antibiotics used and the rates of developed resistance to the antibiotics.Results: A total of 107 patients aged between 1 year and 15 years were included in the study, encompassing 14 (13.1%) males and 93 (86.9%) females. According to the urine culture results, proliferation of Escherichia coli (E. coli) was observed in 69 (64.5%), Klebsiella spp. in 13 (12.1%), Proteus mirabilis in 9 (8.4%), Staphylococcus aureus in 5 (4.7%), Pseudomonas aeruginosa in 5 (4.7%), Acinetobacter spp. in 3 (2.8%) and Enterococcus spp. in 3 (2.8%) patients. For proliferating E. coli, high resistance rates to ceftriaxone (39.5%), nitrofurantoin (19.7%), ampicillin-sulbactam (64.1%), co-trimoxazole (41.5%), amoxicillinclavulanate (51.7%) and cefuroxime (38.1%) were observed. All of isolated microorganisms were resistant to ampicillin-sulbactam, amoxicillin-clavulanate, co-trimoxazole, ceftriaxone, cefuroxime and cefoxitin in decreasing frequencies. The most effective antimicrobial agents were determined to be imipenem, sulperazone, quinolone and aminoglycosides. Conclusion:In our region, parenteral antibiotics that should be selected for the empirical treatment of UTIs in all age groups are the aminoglycosides and 3 rd generation cephalosporines. In contrast to other studies, these results suggest that co-trimoxazole should be used for children aged 0-1, and 2 nd generation cephalosporins should be used for the oral treatment of children aged 1-5 due to the low rate of resistance to nitrofurantoin in patients aged over 5 years.

Bacterial etiology and antimicrobial susceptibility profiles of 7741 urine cultures in outpatients: A 5-year single-center experience in Turkey

“…In our study, Escherichia coli was the most frequently isolated microorganism. Our finding was consistent with similar studies conducted locally [13][14][15][16][17] and internationally [10][11][12]. The main isolated pathogen was E. coli followed by Enterobacter spp, P Mirabilis, K. pneumoniae respectively.…”

Antibiotic drug resistance pattern of uropathogens seen in the first episode of community-acquired pediatric urinary tract infections at a tertiary care hospital

“…8,25 In our study, while resistance to ampicillin, piperacillin, and TMP-SMX was high among all isolates, imipenem, amikacin, and tobramycin had the lowest resistance. All Klebsiella isolates are sensitive to imipenem and amikacin in our study, as in a study by Abuhandan et al 26 However, Wang et al reported resistance to imipenem and amikacin at a frequency of 21.12% and 6.83%, respectively. 6 These results may vary because of the different patient inclusion criteria in different studies.…”

Bacterial Profile and Drug Susceptibility Pattern of Urinary Tract Infection in Infants and Children

“…The percentage of infection in infants (19%) in the present study is same as in the study of H. Solanki et al (20%). [8] and the percentage of infection in children (81%) in the present study is same as in the study of H. Solanki et al [8] (Turky) (80%) and Abuhandan et al [9] (India) (100%).…”