Antibiotic susceptibilities and auxotypes of Neisseria gonorrhoeae strains from women with pelvic inflammatory disease or uncomplicated infections

Abstract

The purpose of the present study was to compare the auxotypes and the minimal inhibitory concentrations of four antibiotics for 50 isolates from women with gonococcal pelvic inflammatory disease with those of 55 isolates from uncomplicated anogenital gonococcal infections. No significant differences in auxotype patterns and susceptibilities were found between isolates from the two groups.

Bacterium of one thousand and one variants: genetic diversity of Neisseria gonorrhoeae pathogenicity.

“…The nutrients used for auxotyping included ornithine, arginine, proline, uracil, hypoxanthine, leucine and methionine. Several auxotypes were defined; however, little association was found between different auxotypes and gonococcal pathogenesis [7, 159–161]. One exception to this is a correlation between DGI and the arginine, hypoxanthine, uracil (AHU) − auxotype with unknown causal mechanisms [162, 163]; another is dependence on lactate metabolism for long-term survival in human cervical epithelial cells, potentially vital for invasion and spread [164].…”