Antibiotic susceptibility of bacteria most commonly isolated from bone related infections: the role of cephalosporins in antimicrobial therapy

Jones, Mark; Karlowsky, James A.; Draghi, Deborah C.; Thornsberry, Clyde; Sahm, Daniel F.; Nathwani, Dilip

doi:10.1016/j.ijantimicag.2003.08.007

Cited by 19 publications

(11 citation statements)

References 16 publications

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“…The sensitivity to cephalosporins was also low but that to aminoglycosides relatively higher (67%). These findings also correlate to the 2003 report of "The Surveillance Network, TSN "USA [17] . The study in Morocco 2014 reported a good (more than 50%) sensitivity to most antibiotics except for Amoxicillin-Clavulanic acid, Ampicillin and Cefalotin [12] .…”

Section: Sensitivity Testingsupporting

confidence: 84%

“…They showed high resistance to aminoglycosides, other cephalosporins, and Cotrimoxazole. This susceptibility rate is relatively low compared to the findings of "The Surveillance Network, TSN "USA which reports high sensitivities (˃78%) of the different enterobacteria strains to quinolones, third generation cephalosporins, and piperacillin/Tazobactam [17] . This difference could be explained by the fact that most of these organisms in our study were probably hospital acquired.…”

Section: Sensitivity Testingcontrasting

confidence: 54%

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Clinical and microbiological profile of post-traumatic osteomyelitis in tertiary hospital in Yaoundé –Cameroon

Ed¹,

Aa²,

Kh³

et al. 2017

Int. J. Orthop. Sci.

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Background: Post-traumatic osteomyelitis is bone infection secondary to a trauma (open fracture or bone surgery). It is a painful and frustrating disease characterised by a high rates of therapeutic failures and a costly management. However, treatment is increasingly becoming difficult because of the phenomenon of antibiotic resistance. The present study was realised to determine the epidemiological and susceptibility profile of bacterial isolates in posttraumatic osteomyelitis in a tertiary hospital in the city of Yaoundé. Method: A descriptive cross-sectional study was carried out between November 2016 and May 2017. Patients admitted for post-traumatic osteomyelitis were recruited. After recoding clinical informations, deep specimens were taken during surgical debridement and were cultured in Blood, Mannitol Salt and MacConkey plates at 37 o C for 24-72hrs. Culture isolates were identified by standard biochemical reactions. Antibiotic susceptibility was performed by Kirby-Bauer method using the CASFM guidelines. Results: A total of 31 patients were recruited; the modal age range was 21-50 years (67.8%) and the sex ratio 1.8:4. The commonest bones affected were the tibia (48.5%) and femur (32.3%). Predisposing factors identified included open fractures (76%), delay surgical debridement (83.3%), presence of prosthesis (58%) and surgical wound infections (23%). Out of 31 samples, 29 yielded positive culture giving rise to 48 bacteria isolates. Fourteen samples (48%) were polybacterial. The most predominant species was Escherichia coli (29%), followed by Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae (all 22.6%). The Gram positive organisms showed good sensitivity to Imipenem, Rifampicin, Fucidine, Lincomycin, and to Vancomycin whereas the Gram negative bacilli were mostly sensitive to Imipenem (96.7%), Amikacin (82.1%) and to a lesser extend Quinolones (54%) and Piperacillin/Tazobactam and Ceftazidime (48%). Conclusion: Nosocomial bacteria dominate the bacterial flora of posttraumatic osteomyelitis in our setting and many multidrug resistant strains are emerging thus emphasizing on the importance of hygiene and targeted antibiotherapy.

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Section: Sensitivity Testingsupporting

confidence: 84%

Section: Sensitivity Testingcontrasting

confidence: 54%

Clinical and microbiological profile of post-traumatic osteomyelitis in tertiary hospital in Yaoundé –Cameroon

Ed¹,

Aa²,

Kh³

et al. 2017

Int. J. Orthop. Sci.

View full text Add to dashboard Cite

show abstract

“…However, S. aureus (susceptible or resistant to methicillin) was still the most commonly isolated organism regardless of aetiology (32%) 5 although it accounted for a considerably lower proportion of cases than previously documented. 13,14 Polymicrobial infections were common (29%) and were not limited to patients with a history of fracture or MW.…”

Section: Discussionmentioning

confidence: 77%

The microbiology of chronic osteomyelitis: Prevalence of resistance to common empirical anti-microbial regimens

Sheehy

Atkins

Bejon

et al. 2010

Journal of Infection

123

112

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“…This surveillance database collects data from over 200 institutions in the United States, and antimicrobial susceptibility testing is performed on-site by each laboratory in accordance with FDA-approved testing methods and interpreted using Clinical and Laboratory Standards Institute (CLSI)-recommended breakpoints. TSN data have been used before to evaluate trends in antimicrobial resistance, and further details of quality control have been described previously (5,9,18,19).…”

mentioning

confidence: 99%

In Vitro Antimicrobial Resistance of Urinary Escherichia coli Isolates among U.S. Outpatients from 2000 to 2010

Sánchez

Master

Karlowsky

et al. 2012

Antimicrob Agents Chemother

222

166

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dThis study examines in vitro antimicrobial resistance data from Escherichia coli isolates obtained from urine samples of U.S. outpatients between 2000 and 2010 using The Surveillance Network (TSN). Antimicrobial susceptibility results (n ‫؍‬ 12,253,679) showed the greatest increases in E. coli resistance from 2000 to 2010 for ciprofloxacin (3% to 17.1%) and trimethoprim-sulfamethoxazole (TMP-SMX) (17.9% to 24.2%), whereas nitrofurantoin (0.8% to 1.6%) and ceftriaxone (0.2% to 2.3%) showed minimal change. From 2000 to 2010, the antimicrobial resistance of urinary E. coli isolates to ciprofloxacin and TMP-SMX among outpatients increased substantially.

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Antibiotic susceptibility of bacteria most commonly isolated from bone related infections: the role of cephalosporins in antimicrobial therapy

Cited by 19 publications

References 16 publications

Clinical and microbiological profile of post-traumatic osteomyelitis in tertiary hospital in Yaoundé –Cameroon

Clinical and microbiological profile of post-traumatic osteomyelitis in tertiary hospital in Yaoundé –Cameroon

The microbiology of chronic osteomyelitis: Prevalence of resistance to common empirical anti-microbial regimens

In Vitro Antimicrobial Resistance of Urinary Escherichia coli Isolates among U.S. Outpatients from 2000 to 2010

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