Antibiotic Susceptibility of <i>Streptococcus Pyogenes</i> Isolated from Respiratory Tract Infections in Dakar, Senegal

Camara, Makhtar; Dieng, Assane; Boye, Cheikh Saad Bouh

doi:10.4137/mbi.s12996

Cited by 55 publications

(53 citation statements)

References 29 publications

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“…All Streptococcus pyogenes isolated in this study were sensitive to Clindamycin and Vancomycin while they were absolutely resistant to Levofloxacin and Erythromycin. Very similar antibiotic sensitivity patterns of Streptococcus pyogenes are reported earlier [21,22]. The majority of Streptococcus pneumoniae were resistant against Co-Trimoxazole, Clindamycin, and Erythromycin.…”

Section: Discussionsupporting

confidence: 78%

Antibiotic Susceptibility Profile of respiratory pathogens obtained at tertiary care hospital from western Nepal

et al. 2019

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The prevalence and drug resistance of the respiratory pathogens is increasing gradually in Nepal. However, their detail study is rare in the western region of Nepal. Hence, this study was carried out to know the incidence and antibiotic susceptibility profile of the respiratory pathogens obtained at a tertiary care center located at Pokhara. 139 pathogens were isolated from 460 clinical samples included. Significant pathogens were Gram-negative bacteria 94 (67.62%), followed by 28 (20.15%) Candida, and Gram-positive isolates 17 (12.23%). The growth rate was significantly higher for sputum samples in comparison to throat swabs. Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter were significant Gram-negative isolates while Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes were Gram-positive pathogens. Sensitivity rate was higher for colistin and imipenem among Gram-negative isolates while lower sensitivity was for cefepime. Vancomycin was effective against all tested Gram-positive isolates while erythromycin and ciprofloxacin were less effective.

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Section: Discussionsupporting

confidence: 78%

Antibiotic Susceptibility Profile of respiratory pathogens obtained at tertiary care hospital from western Nepal

et al. 2019

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“…We evaluated local antibiotic concentrations to determine whether the concentrations contained in the eluent exceeded the MIC of common infecting pathogens and concentrations in the serum were also evaluated for all subjects [44][45][46][47]. Table 3 lists the results.…”

Section: Resultsmentioning

confidence: 99%

Elution Profiles of Synthetic CaSO4 Hemihydrate Beads Loaded with Vancomycin and Tobramycin

Maale¹,

Eager²,

Mohammadi³

et al. 2020

Eur J Drug Metab Pharmacokinet

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Backgrounds and Objectives The use of local antibiotic delivery vehicles is common in the management of biofilm-related infections as they provide high concentrations of local antibiotics while simultaneously avoiding complications from systemic toxicity. We present a 100% pure synthetic calcium sulfate hemi-hydrate mixed with 240 mg tobramycin and 500 mg vancomycin per 10 cc mixture for use in revision surgeries of periprosthetic joint infections (PJIs). The purified carrier demonstrates bioabsorbablity, promotion of bone growth, a physiologically favorable pH, and hydrophilicity. These unique properties may alleviate persistent postoperative wound drainage seen in patients with PJI. Our questions consist of two parts: (1) does the novel calcium sulfate carrier provide therapeutic concentrations of antibiotic locally that can kill biofilm related infections? (2) Are serum concentrations of antibiotic significant to cause concern for systemic toxicity? Methods To address these questions, we assayed the elution of antibiotic concentrations obtained from surgical drains and serum among 50 patients in the first 5 postoperative days. Results The elution of vancomycin and tobramycin was greatest on day 1 compared with those concentrations obtained on days 2, 3, 4, and 5; serum concentrations were largely undetectable. Our findings demonstrate that this calcium sulfate preparation provides therapeutic delivery of vancomycin and tobramycin locally at log 2-3 above the minimum inhibitory concentration (MIC), while avoiding toxic serum concentrations. Conclusions When used in one-stage revision arthroplasties, the bioabsorbable, purified carrier delivers high concentrations of antibiotic while avoiding systemic toxicity.

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“…Tetracycline (30µg) was sensitive to 7 isolates (33.3%) out of total 21 isolates and resistant in case of 14 isolates (66.7%) respectively. Some previous studies also showed high rate of tetracycline resistance conducted by Jasir A et al [28] showing 42% resistance by standard disc diffusion method as well as 100% resistance shown by study conducted by Camara M et al [29] and 18% resistance by Devrim Dunda et al [30] respectively.…”

Section: IImentioning

confidence: 89%

Prevalance of Streptococcus pyogenes infection in children aged between 5 to 15 years with acute tonsillopharyngitis and its antibiogram

Sharma¹,

Praveen²,

Devi³

et al. 2014

IOSRJDMS

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Antibiotic Susceptibility of Streptococcus Pyogenes Isolated from Respiratory Tract Infections in Dakar, Senegal

Cited by 55 publications

References 29 publications

Antibiotic Susceptibility Profile of respiratory pathogens obtained at tertiary care hospital from western Nepal

Antibiotic Susceptibility Profile of respiratory pathogens obtained at tertiary care hospital from western Nepal

Elution Profiles of Synthetic CaSO4 Hemihydrate Beads Loaded with Vancomycin and Tobramycin

Prevalance of Streptococcus pyogenes infection in children aged between 5 to 15 years with acute tonsillopharyngitis and its antibiogram

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