Antibiotic susceptibility of Kingella kingae isolates from respiratory carriers and patients with invasive infections

Yagupsky, Pablo; Katz, Orna; Peled, Nechama

doi:10.1093/jac/47.2.191

Cited by 71 publications

(47 citation statements)

References 7 publications

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“…In this sense, its susceptibility to fluoroquinolones is conflicting and requires further investigation. In our case ciprofloxacin was initially given as the isolates were misidentified as K. kingae, which was indicated as being susceptible to ciprofloxacin (Roiz et al, 1997;Yagupsky et al, 2001), but the patient did not improve. Afterwards, the antibiotic treatment was switched to piperacillin/tazobactam and the patient recovered successfully.…”

Section: Discussionmentioning

confidence: 90%

“…Antibiotic susceptibility tests (ASTs) were not performed because of the lack of Clinical and Laboratory Standards Institute (CLSI) approved standards for K. kingae. On the basis of the known susceptibility of K. kingae to ciprofloxacin (Yagupsky et al, 2001), the treatment program was continued. The second pleural fluid sample was collected 2 days after the first one, and after 24 h of incubation its culture yielded the same organism, which was shown to be K. kingae by the Phoenix system again.…”

Section: Case Reportmentioning

confidence: 99%

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Pleuritis due to Brevundimonas diminuta in a previously healthy man

Shi

Zhu

et al. 2013

Journal of Medical Microbiology

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Brevundimonas diminuta is rarely associated with invasive infections. We report the case of a previously healthy young man with pleural effusion, in which B. diminuta was recovered but incorrectly identified as Kingella kingae when it was freshly isolated. Consequently, the misidentification resulted in initial treatment failure. The correct identification was achieved through further incubation, sequencing of the 16S rRNA gene and MS.

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Section: Discussionmentioning

confidence: 90%

Section: Case Reportmentioning

confidence: 99%

Pleuritis due to Brevundimonas diminuta in a previously healthy man

Shi

Zhu

et al. 2013

Journal of Medical Microbiology

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“…Yagupsky et al hypothesize that prevalence of K. kingae could be reduced by exposure to antibiotics during the winter months, since K. kingae is highly sensitive to antibiotics commonly used for respiratory infections (13,25). In our study of asymptomatic carriage, throat swabs were collected only from children without clinical findings of OAI who did not receive any antibiotic treatment in the previous 2 mo.…”

Section: Discussionmentioning

confidence: 99%

Oropharyngeal Kingella kingae carriage in children: characteristics and correlation with osteoarticular infections

et al. 2015

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“…Because the occurrence of respiratory infections follows a seasonal pattern, the population in general, and especially young children, is more commonly given antimicrobial drugs during the winter (1). Therefore, the prevalence of K. kingae could have been reduced by previous exposure to drugs such as ␤-lactams, trimethoprim-sulfamethoxazole, or macrolides, which are commonly given to patients with respiratory infections and to which the organism is exquisitely susceptible (26). Although no actual data on antibiotic exposure were collected in the present study, it should be pointed out that throat cultures are usually obtained before the onset of antimicrobial therapy.…”

Section: Streptococcus Pneumoniae Haemophilus Influenzae Type B Ormentioning

confidence: 99%

Epidemiological Features of Invasive Kingella kingae Infections and Respiratory Carriage of the Organism

2002

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The age, sex, and seasonal distributions of invasive Kingella kingae infections in southern Israel were examined and compared to the epidemiology of respiratory carriage of the organism. Medical records of all patients diagnosed between 1988 and 2002 were reviewed, and 2,044 oropharyngeal specimens were cultured on selective media during two periods (February to May and October to December) in 2001. Invasive infections significantly affected children (73 of 74 patients [98.6%] were younger than 4 years), 50 patients (67.8%) were males (P ‫؍‬ 0.045), and 55 episodes (74.3%) occurred between July and December (P ‫؍‬ 0.004). Carriage was higher in the 0-to 3-year-old group and decreased with increasing age (P for trend ‫؍‬ 0.0008). Carriage rates were similar in both sexes and did not significantly differ between the February-to-May and October-toDecember periods. The highest rate of carriage of K. kingae coincided with the age (less than 4 years) at which invasive infections were especially frequent. The peculiar sex and seasonal distributions of invasive disease, however, cannot be readily explained by the epidemiology of respiratory carriage. Viral infections and other yet-to-be-defined cofactors may play a role in the causation of invasive K. kingae infections.For most of the four decades that elapsed since the first characterization of Kingella kingae, this gram-negative bacterium was considered a rare cause of human disease and therefore was mostly neglected (5,8,20). In recent years, as the result of improved isolation techniques, there has been an increasing number of reports on invasive K. kingae infections in the United States, Western Europe, and Israel, suggesting that the organism is an important cause of bacteremia and septic arthritis in pediatric patients (2,4,6,7,13,14,21,22,25). Moreover, studies conducted to elucidate the natural niche of K. kingae have shown that the organism is a frequent component of the oropharyngeal flora of young children and is readily transmitted from person to person among day care center (DCC) attendees (19,24).Despite the enlarging body of information on the clinical and diagnostic aspects of K. kingae infections, the epidemiology of the organism remains largely unknown. A study was performed to investigate the sex, age, and seasonal distributions of invasive K. kingae infections and to correlate these data with the respiratory carriage of the organism. MATERIALS AND METHODSSoroka University Medical Center (SUMC) is a 950-bed university hospital located in the city of Beer-Sheva and is the only medical facility providing inpatient medical services to the entire population of southern Israel (450,000 inhabitants). The Clinical Microbiology Laboratory (CML) of SUMC provides diagnostic microbiology services to hospitalized patients and to the outpatient population of 139 community clinics in the area.Bacteriological methods. Patients referred to the emergency department or hospitalized at SUMC with a febrile illness undergo routine blood cultures with the BACTEC system (B...

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Antibiotic susceptibility of Kingella kingae isolates from respiratory carriers and patients with invasive infections

Cited by 71 publications

References 7 publications

Pleuritis due to Brevundimonas diminuta in a previously healthy man

Pleuritis due to Brevundimonas diminuta in a previously healthy man

Oropharyngeal Kingella kingae carriage in children: characteristics and correlation with osteoarticular infections

Epidemiological Features of Invasive Kingella kingae Infections and Respiratory Carriage of the Organism

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