ANTIBIOTIC SUSCEPTIBILITY OF NEISSERIA <i>GONORRHOEAE</i> IN RELATION TO SEROGROUPS

Bygdeman, S

doi:10.1111/j.1699-0463.1981.tb00181_89b.x

Cited by 11 publications

(2 citation statements)

References 27 publications

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“…The distribution into serogroups of gonococcal strains isolated from patients in Stockholm, Trondheim, Oslo, Copenhagen and Helsinki in 1982, as well as in Stockholm 198 I(4).…”

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confidence: 99%

Gonococcal W Serogroups in Scandinavia

Bygdeman

Danielsson²,

Sandström

et al. 1983

Acta Pathologica Microbiologica Scandinavica Series B: Microbio

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A total of 849 gonococcal strains from 659 patients in Copenhagen (Denmark), Helsinki (Finland), Oslo and Trondheim (Norway) and Stockholm (Sweden) were included in the study. Using co‐agglutination reagents with polyclonal and monoclonal antibodies the strains were serogrouped into the previously described gonococcal serogroups W I, W II and W III. W II strains were dominating in all five towns (60.0%‐70.9% of the strains), but W III strains were rarely isolated. W I strains were more frequent among women than among men. With the monoclonal reagents, W I, W II and W III strains could be further subdivided into 12, 29 and two different serovariants (serovars), respectively. One of the W I serovars was dominating (76%‐94% of W I strains) in all five towns, and apart from this serovar, only three to five other W I serovars were seen in each town. Of W II strains, on the other hand, a greater variety of serovars were seen: between six in Trondheim and 17 in Oslo, and no one was dominating as among W I strains. Different W II serovar patterns were found in the different towns. Even between the two participating laboratories in each of the towns, Oslo and Helsinki, differences were noted. The epidemiological value of this is discussed. Ten of the 11 β‐lactamase‐producing gonococcal strains isolated belonged to unusual serovars. None of the monoclonal co‐agglutination patterns corresponded to a single polyclonal pattern. There were, however, some relations between the two systems. In earlier studies it was shown that in smaller Swedish towns W I strains dominated. A hyphothesis about protective anti‐Protein I antibodies is discussed to explain the differences in distribution of W I and W II strains between smaller and larger towns and between women and men.

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“…The distribution into serogroups of gonococcal strains isolated from patients in Stockholm, Trondheim, Oslo, Copenhagen and Helsinki in 1982, as well as in Stockholm 198 I(4).…”

mentioning

confidence: 99%

Gonococcal W Serogroups in Scandinavia

Bygdeman

Danielsson²,

Sandström

et al. 1983

Acta Pathologica Microbiologica Scandinavica Series B: Microbio

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“…In serogroup W I no difference was noted concerning importation in relation to sex and sexual preference, while isolates in sero group W II/llI most frequently were imported by men. This influx of W II/III strains could be a source of future changes of the serovar pattern in Sweden and is a matter of great concern since W II/III strains are less susceptible to antibiotics than W I strains (14). On the other hand beterosexual men who had acquired their infection abroad were older than those, who had got their infection in Sweden.…”

Section: Discusslonmentioning

confidence: 99%

Analysis of serovar distribution as a tool in epidemiological studies in gonorrhoea

Rudén,

Bäckman,

Bygdeman

et al. 1986

Acta Derm Venereol

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During one year 738 gonococcal isolates from 731 consecutive patients with gonorrhoea were collected and classified by co-agglutination using W I and W II/III specific monoclonal antibodies. Eight W I and 30 W II/III serovars (serovariants) were seen. In both serogroups the most frequent serovar among isolates from women and heterosexual men differed from that among isolates from homosexual men. Forty-two per cent of the serovars, were confined only to one subpopulation, i.e. women, heterosexual men or homosexual men, representing 19 (3%) of the 738 isolates. Out of these 19 isolates 42% were acquired abroad compared with 12% of the 653 isolates in the serovars shared between two or all three subpopulations (p less than 0.005). Imported W I isolates were often of the same serovar that dominated in Stockholm. W II/III isolates acquired abroad were often of unusual serovars (p less than 0.0005) and might be a source of future changes of the serovar pattern in Sweden. In this way we can follow the introduction of new serovars into our society and their circulation between the subpopulations.

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