Antibiotic susceptibility of respiratory isolates among HIV-positive children in Kyrgyzstan is higher compared to those Cambodia: Is outpatients status important

Šuvada, J.; Líšková, Anna; Sladeckova, V.; Benca, Juraj; Görnerová, Lenka; Mikolasova, G.; Kafková, J; Vujcikova, J.; Kalavska, A.; Minarik, P.; Krčméry, V.; Kulkova, N.; Stalbek, M.

doi:10.22359/cswhi_7_3_09

Cited by 1 publication

(3 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The proportion of pharyngeal colonization of M . catarrrhalis (12.3%) in the current study was higher than previous reports in Cambodia (6.2%) and Kyrgz (7.2%) [ 26 ]. However, it was lower than findings reported in Estonia (16%) [ 28 ], Ghana (39.8%) [ 31 ], Tanzania (50%) [ 33 ], south central Tanzania (90.8%) [ 35 ], Seoul, Korea (20.2%) [ 3 ] and Turkey (23.9%) [ 27 ].…”

Section: Discussioncontrasting

confidence: 83%

“…aureus was the predominant organism carried by the HIV positive children in this study. However, in similar studies at Cambodia [ 26 ] and Turkey [ 27 ], M . catarrrhalis was reported as the leading isolate.…”

Section: Discussionmentioning

confidence: 96%

“…However, higher colonization rate was documented in North and South Ethiopia (41–43.8%) [ 9 , 25 ], Estonia (17%) [ 28 ], Uganda (18%) [ 29 ], West Bengal (15.6%) [ 30 ], Ghana (30.5%) [ 31 ], Rural Uganda (58.6%) [ 32 ], Tanzania (56%) [ 33 ]and South Africa (22.2%) [ 34 ]. On the other hand, lower (5.1%) colonization rate was documented in Cambodia [ 26 ]. The variation in the colonization rate might be due to difference in the age range of participants, vaccination status, living condition, season of data collection and methodology.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Pharyngeal colonization and drug resistance profiles of Morraxella catarrrhalis, Streptococcus pneumoniae, Staphylococcus aureus, and Haemophilus influenzae among HIV infected children attending ART Clinic of Felegehiwot Referral Hospital, Ethiopia

et al. 2018

View full text Add to dashboard Cite

BackgroundAsymptomatic pharyngeal colonization by potential bacteria is the primary reservoir for bacterial species within a population and is considered a prerequisite for development of major childhood diseases such as sinusitis, otitis media, pneumonia, bacteremia, and meningitis. However, there is dearth of data on the colonization and drug resistance pattern of the main bacterial pathogens in the pharynx of HIV infected children in Ethiopia. Therefore, this study determined the pharyngeal colonization and drug resistance profile of bacterial pathogens in HIV infected children attending ART clinic of Felegehiwot Referral Hospital (FHRH), Amhara Region, Ethiopia.MethodsA hospital based cross-sectional study was conducted from May 2016 to June 2017 at the ART clinic of FHRH. A total of 300 HIV infected children were enrolled in the study. Data on socio-demographic characteristics of the study participants were collected with face-to-face interview and patient—card review using structured questionnaire. Bacterial species were identified using standard bacteriological techniques. Drug susceptibility testing was performed using disk diffusion technique. Chi-square test was done to determine associations among variables.ResultsThe median age of the participants was 11 years. Overall, 153 (51%) of children were colonized by respiratory bacteria in their pharynx. Colonization rate was higher in children from mothers who had attained college and above levels of education than others (P = 0.04). It was also higher in children without the sign of malnutrition than others (P = 0.004). The colonization rate of S.aureus, M.catarrhalis, S.pneumoniae and H.influenzae were 88 (29%), 37 (12.3%), 31 (10.3%) and 6 (2%), respectively. S.aureus—M.catarrhalis concurrent colonization was found in 14 (4.7%) of children. Age (P = 0.03), schooling (P = 0.045) and history of running nose (P = 0.043) were significantly associated with S.aureus colonization. Living in urban setting (P = 0.042) and children from mothers with college and above levels of education (P = 0.002) were significantly associated with M.catarrhalis colonization. Majority of the isolates were resistant to penicillin (68.5%) and cotrimoxazole (52.5%).S.aureus isolates were resistant to penicillin (84.1%) and cotrimoxazole (51.1%).M.catarrhalis isolates were resistant to penicillin (94.6%), erythromycin (86.5%)and cotrimoxazole (78.4%). Overall, 99 (59.3%) of the isolates were multi-drug (MDR) resistant. The overall MDR rates among S.aureus, M.catarrhalis and S.pneumoniae isolates were 65.9%, 78.4% and 22.6%, respectively.ConclusionsPharyngeal colonization of respiratory bacteria in HIV infected children is a major public health problem. Single and multiple antibiotic resistant is alarmingly high among respiratory colonizers. Therefore, regular screening of HIV infected children for culture and antimicrobial susceptibility testing is recommended to prevent the development of severe opportunistic infections.

show abstract