Antibiotic Susceptibility Pattern of Bacterial Pathogens Isolated from Infected Lesions

Sherchan, Jatan Bahadur; Gurung, Pranita

doi:10.33314/jnhrc.v16i41.1631

Cited by 3 publications

(3 citation statements)

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“…15 The current investigation found that out of 127 samples, 64 (50.39%) were culture positive, which is quite comparable to the results observed by Saleh et al (2008) in Bangladesh (48.19%), Gautam et al (2002) in northern India (37.7%), and Maharjan et al (2008) in Nepal (48.96%). 20,21,22 Comparatively, a 2018 study in Bangladesh found an isolation rate of 63.33 percent, which was significantly higher than the present study. 23 This high rate of isolation may be due to the prevalence of automated blood culture techniques.…”

Section: Figure-iii: Bacterial Identification By Automated Blood Cult...supporting

confidence: 83%

Detection of Salmonella species by Automated Blood Culture Method in Suspected Cases of Enteric Fever

Sazzad,

Alam,

Haque

et al. 2023

TAJ: J of Teachers Assoc

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Background: Enteric fever caused by Salmonella species is a systemic febrile illness that can be fatal since its characterization in 1880. Enteric fever may remain asymptomatic carrier and sometimes fatal that it can be difficult to diagnose based on symptoms alone because they are similar to those of other febrile disorders. In developing countries, enteric fever is common global health problem due to poor standard of personal hygiene, contaminated food, inadequate safe water and sanitation. Methods: This is a cross-sectional study that was conducted in the Microbiology Department of Rajshahi Medical College Hospital for one year from January 2021 to December 2021 to identify Salmonella species by Automated Blood Culture (Fastidious Antibiotic Neutralization method) followed by subculture in MacConkey’s agar, Xylose lysine deoxycholate agar, and Salmonella Shigella agar media in suspected enteric fever cases. This study included suspected cases of enteric fever as determined by the physician who fulfilled the inclusion and exclusion criteria. Results: Among 127 suspected cases of enteric fever 64(50.39%) culture positive bacteria isolated by automated blood culture (FAN) method and out of that Salmonella species 38 (59.37%) and others bacteria 26(40.63%) following subculture in MacConkey’s agar, Xylose lysine deoxycholate agar and Salmonella Shigella agar media. Regarding gender, the majorities (61.4%) of culture-positive patients were male, and the majority (65.35%) came from rural areas. Conclusion: Especially for patients who have received antibiotics, we propose that the automated blood culture approach followed by subculture could be employed as a novel diagnostic method for typhoid fever. TAJ 2023; 36: No-2: 71-76

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Section: Figure-iii: Bacterial Identification By Automated Blood Cult...supporting

confidence: 83%

Detection of Salmonella species by Automated Blood Culture Method in Suspected Cases of Enteric Fever

Sazzad,

Alam,

Haque

et al. 2023

TAJ: J of Teachers Assoc

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“…The most effective drugs against MRSA are linezolid and vancomycin with 100% sensitivity, followed by amikacin (79.3%). The results of the same study were shown by Sherchan and Gurung (2019) with an effective antibiotic for ESBL, namely imipenem (carbapenems) (93.8%) which also showed the highest sensitivity (97.14%) to meropenem (carbapenems). This small difference may be due to the geographically varying prevalence of ESBL-producing isolates.…”

Section: Discussionmentioning

confidence: 60%

Bacteriological Profile of Wound Infection and Antibiotic Susceptibility Patterns in a Public Hospital in Surabaya, Indonesia

Ayunur Kholifah,

Wahyu Indriati,

Wahyuni

et al. 2023

J Vocat Heal Stud

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Background: Pyogenic infections that occur can be caused by direct bacterial contamination of the wound, such as infection in a post-surgical wound or infection after trauma. Efforts to control infection can be done with the use of antibiotics. Purpose: To determine the profile of bacteria and antibiotic sensitivity in wound culture in hospitalized patients in Hajj General Hospital Surabaya, East Java in 2021. Method: This study used the Chi-square test and descriptive analysis in the form of distribution tables and percentages using secondary data based on the results of examination of pus culture at the Clinical Microbiology Laboratory in Hajj General Hospital Surabaya, East Java in 2021. Result: The results of research on wound culture samples showed as many as 113 patients (56.22%) with positive culture results, which were predominantly female as many as 59 patients (50.9%) and the highest age category namely at the age of 46-55 years as many as 39 patients (33.6%). Based on bacteria, the most dominant type of bacteria in the Gram-negative group was Escherichia coli ESBL with 21 isolates (26.6%), while Gram-positive bacteria, Staphylococcus aureus, was found in 16 isolates (43.3). The results of antibiotic sensitivity on Gram-negative bacteria were Piperacillin/Tazobactam and Meropenem, and on Gram-positive bacteria Vancomycin and Linezolid were obtained. Conclusion: E. coli and S. aureus are the most important causes of wound infections and the suppressor organisms in this study. Antibiotic susceptibility testing of all isolates showed that the antibiotics amikacin and meropenem were sensitive to Gram-negative bacteria especially ESBL-producing bacteria, and the antibiotics vancomycin and linezolid were sensitive to Gram-positive bacteria especially MRSA.

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“…Even if new antibiotics are developed, without behavior change, antibiotic resistance will continue to be a major threat [6]. In the meantime, information about the antibiotic spectrum of activity against existing MDR strains may help reduce the rate of emergence and spread of antimicrobial resistance [7].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Resistance and Biofilm Production in Uropathogens from Renal Disease Patients Admitted to Tribhuvan University Teaching Hospital, Nepal

Dahal

Shrestha

Karki

et al. 2023

Journal of Clinical Pharmacy and Therapeutics

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Background. Various antibiotics are prescribed empirically by physicians to cope with infections in renal disease patients. A urinary tract infection (UTI) is often caused by biofilm-forming multidrug-resistant (MDR) uropathogens. This study aimed to analyze the antibiogram of UTI strains from renal disease patients and the biofilm-forming ability of those strains. Methods. 102 patients clinically diagnosed with a UTI and renal disease were recruited into the study from August 2017 to January 2018. Clean-catch midstream urine samples were processed for the isolation and identification of the bacteria following standard methodologies. The antibiogram of the isolates (n = 106) was produced by the Kirby–Bauer disc diffusion method. Detection of biofilm formation was performed in tissue culture plates. Results. The incidence of a UTI in renal disease was 19.1%. Most patients were diagnosed with chronic kidney disease (18.63%), nephrotic syndrome (16.67%), and nephrolithiasis (14.71%). The commonest uropathogens were Escherichia coli (52.8%), Klebsiella pneumoniae (16%), and Enterococcus spp. (15.0%). Ceftriaxone was the most common antibiotic prescribed empirically (37%), whereas nitrofurantoin was the most prescribed antibiotic as adjusted therapy (36.1%). Among the first- and second-line antibiotics, most Gram-negative bacteria were sensitive to amikacin (70.7%), meropenem (70.7%), cefoperazone-sulbactam (70.0%), piperacillin-tazobactam (67.2%), gentamicin (66.7%), and nitrofurantoin (66.7%). Most Gram-positive bacteria were sensitive to doxycycline (90.0%), nitrofurantoin (72.2%), gentamicin (66.7%), and tetracycline (62.5%). All MDR Gram-negative uropathogens were susceptible to colistin sulfate and polymyxin B. Among the 106 isolates, 74.5% produced biofilms and 70.8% were MDR. In 67.0% of cases, including both MDR and biofilm-producing bacteria, the empirical therapy needed adjustment. Conclusions. Aminoglycoside, carbapenem, beta-lactam inhibitor, and nitrofuran group of antibiotics may be the optimal first-line empirical therapies for uropathogens in hospitalized renal disease patients. Regular surveillance of resistance patterns and the study of biofilm formation in uropathogens must be performed to ensure effective management of the patients.

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Antibiotic Susceptibility Pattern of Bacterial Pathogens Isolated from Infected Lesions

Cited by 3 publications

References 0 publications

Detection of Salmonella species by Automated Blood Culture Method in Suspected Cases of Enteric Fever

Detection of Salmonella species by Automated Blood Culture Method in Suspected Cases of Enteric Fever

Bacteriological Profile of Wound Infection and Antibiotic Susceptibility Patterns in a Public Hospital in Surabaya, Indonesia

Antimicrobial Resistance and Biofilm Production in Uropathogens from Renal Disease Patients Admitted to Tribhuvan University Teaching Hospital, Nepal

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