Antibiotic susceptibility pattern of Staphylococcus aureus in tertiary care hospital, SRMSIMS, Bareilly, U.P.

Abstract

Background: S. aureus has been recognized as continuously challenging the clinicians despite the availability of antibiotics from nearly 70 yrs and emergence of various types of antibiotic resistance mechanisms especially to methicillin and vancomycin, which was the theme of this study. The study was to determine the antibiotic susceptibility of Staphylococcus aureus in Tertiary Care Hospital, SRMSIMS, Bareilly and also to determine the current status of Vancomycin susceptibility in our Hospital setup considering E-Test as gold standard.Methods: This study was prospective in design from 1st January 2014 to 31st December 2014 and conducted in the Department of Microbiology, SRMSIMS, Bareilly. All S. aureus strains were screened for vancomycin resistance by Dual strip E- test.Results: Out of 505 Staphylococcus aureus isolates, we found that MRSA, VISA, and VRSA as 80.8%, 0.6% and 0.0% respectively. In cases of MRSA, antibiogram showed sensitivity in the range of 99.4 -100% for glycopeptides, and sensitivity to levofloxacin, chloramphenicol was 77.5% and 65.2% respectively.Conclusions: On evaluation of MIC by E-strips, we found that 17% of MRSA were showing MIC values quite near to the MIC value of VISA. So, these strains may convert to VISA, if the injudicious use of vancomycin antibiotics is not stopped.

Antibiotic Susceptibility Pattern of Methicillin Sensitive and Resistant Staphylococcus aureus from Clinical Isolates in a Tertiary Care Hospital at Mathura, Western Uttar Pradesh

“…Researchers have also reported varying level of resistance to clindamycin and doxycycline among MRSA. Gupta et al 6 in his studies reported 75.5% of MRSA isolates were resistant to clindamycin and in contrast, Mamtora et al 17 reported 73% of MSSA strains were resistant. In our study 50% of MRSA and 25% of the MSSA strains were resistant to clindamycin.…”

“…Data on the prevalence of MRSA is not uniform. Literature has documented a significant variation in the prevalence rate from different parts of India and between countries [1][2][3][4][5][6][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] . Studies from India report MRSA prevalence ranging from 6.9% to 87% 9 .…”

“…Further, people with open draining wounds and infections spread the MRSA in the community. As reviewed by Gupta et al, 6 nosocomial infections caused by MRSA increased from 30% in 1990's to 80% in 2010 in many countries. In India, it varies from 29% in 2009 to 47% in 2014 3 .…”

Methicillin Resistant Staphylococcus Aureus;

“…Many other researchers have also reported resistance to ciprofloxacin (70-80%) followed by erythromycin (60-80%), trimethoprim/sulfamethoxazole and/or cotrimoxazole (60-80%) and 50-70% resistance to gentamicin. 14 Resistance to penicillin is documented by Gupta et al (2017) and Mehta et al (2017). 22,23 Similarly, Dat et al (2017) has documented 100% sensitivity to vancomycin and linezolid, as given in our study.…”

“…14 Resistance to penicillin is documented by Gupta et al (2017) and Mehta et al (2017). 22,23 Similarly, Dat et al (2017) has documented 100% sensitivity to vancomycin and linezolid, as given in our study. 24 All these findings are equally in comparison with our study.…”