Antibiotic susceptibility patterns of Uropathogenic Escherichia coli among patients with urinary tract infections in a tertiary care hospital in Maiduguri, North Eastern, Nigeria

Abdu, Abdulrasheed; Kachallah, Mohammed; Bolus, Dalhatu Yusuf

doi:10.31248/jbbd2017.060

Cited by 7 publications

(7 citation statements)

References 61 publications

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“…Similarly, it also demonstrated in other related studies. High resistance rate was observed 30 (88.2%) of E. coli isolates against two or more commonly used antibiotics in the study setting, these were also reported in previous studies with similar situations [2,12,16] as these may be associated with different variables such as incomplete duration of drugs, easy availability of drugs, selfmedication practices, lack of strict laws of on drugs that punishes for drug misuses hence all this contributed to high emerging rate of drug resistance [11,13]. Therefore, strong policy measurements of antibiotic usage were to be put in to place to curb these misuse of drugs, and also regular monitoring of the emerging of multi-drug resistance uropathogens have to be carried out to ensure the golden age of antibiotic are maintained.…”

Section: Discussionsupporting

confidence: 86%

“…The most predominant uropathogen that causes UTI among outpatients at Shaafi Hospital was E. coli, as it had concurred with previous studies from different geographic areas [14,[16][17][18][19] However, this was inconsistent with a study from the southwest of Nigeria, which reported Klebsiella spp to be the most prevalent uropathogen, and these might have contributed by the differences in the study design, environmental factors, and also patient selection criteria [12]. S. aureus being the second most frequent uropathogen was not a unique case only to this study [20,5] and this might be due to complicated UTI since it is known to cause bacteremia which could disseminate to urinary to urinary tract [20] also pseudomonas aeruginosa is also considered to be among organisms responsible for urinary tract infections [5].…”

Section: Discussionsupporting

confidence: 85%

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Antibiotic resistance pattern of Escherichia coli isolates from outpatients with urinary tract infections in Somalia

Mohamed

Omar

Hussein

et al. 2020

J Infect Dev Ctries

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Introduction: Several studies suggest increasing rates of antibiotic resistance among adult populations with Urinary tract infections (UTI). Escherichia coli (E. coli), is the predominant bacterium both in the community and in hospital environments causing uropathogenic infections. This study aimed to estimate the common uropathogen bacteria that cause UTI among outpatients as well as to determine the antibiotic resistance pattern of E. coli isolates among outpatients with UTI infections at Shaafi hospital, Mogadishu, Somalia. Methodology: A cross-sectional study was conducted at Shaafi Hospital, Mogadishu, Somalia. A total of 128 samples were collected from outpatients suspected of UTI and tested through bacteriological investigations and antimicrobial susceptibility tests following the Kirby-Bauer agar disc diffusion method. Results: E. coli was isolated in 34 (41%) out of the total 83 samples that showed growth followed by Staphylococcus aureus 22 (26.5%), Pseudomonas aeruginosa, 13 (15.7%), Klebsiella pneumoniae 8 (9.6 %) and Proteus spp. 6 (7.2%). E. coli was highly sensitive to nitrofurantoin, 29 (85.3%), and ciprofloxacin (n = 23, 67.6%), and had the highest resistance rate of ceftriaxone, 33 (97.1%). The odds of having UTI were higher in patients with a history of UTI (Odds ratio OR = 0.211, 95% confidence interval CI: 0.080, 0.553) and history of antibiotic use (OR = 0.322, 95% CI: 0.113, 0.917). Increased resistance rate of E. coli against cephalosporins could be due to its excessive use as empirical therapy. Conclusion: The study indicates that outpatients with UTI could be at high risk of antibiotic resistance, suggesting regular surveillance and monitoring of antibiotics.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 85%

Antibiotic resistance pattern of Escherichia coli isolates from outpatients with urinary tract infections in Somalia

Mohamed

Omar

Hussein

et al. 2020

J Infect Dev Ctries

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“…Resistance to ceftriaxone could be due to transmission of resistant strains/isolates among hospitalized patients and noncompliance with medication. To reduce the incidence of resistance, empirical antibiotic selection in treatment of UTI must be based on the knowledge of local prevalence of causative uropathogens and their respective antimicrobial sensitivities rather than on universal guidelines [58].…”

Section: Discussionmentioning

confidence: 99%

Distribution of virulence genes and phylogenetics of uropathogenic Escherichia coli among urinary tract infection patients in Addis Ababa, Ethiopia

et al. 2020

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Background: Urinary tract infection (UTI) is a common cause of morbidity worldwide. Uropathogenic Escherichia coli (UPEC) bacteria are the major cause of urinary tract infections. UPEC strains derive from different phylogenetic groups and possess an arsenal of virulence factors that contribute to their ability to overcome different defense mechanisms and cause disease. The objective of this study was to identify phylogroup and virulence genes of UPEC among urinary tract infection patients. Methods: A cross sectional study was conducted from January 1, 2017 to October 9, 2017. E. coli bacteria were isolated from UTI patients using culture and conventional biochemical tests. Identification of phylogroup and genes that encodes for virulence factors was done using multiplex polymerase chain reaction (PCR). Data was processed and analyzed with SPSS version16.0 and Epi-info version 3.4.1 software. Results: The most common urologic clinical manifestation combinations in this study were dysuria, urine urgency and urgency incontinence. The frequent UPEC virulence gene identified was fimH 164 (82%), followed by aer 109 (54.5%), hly 103 (51.5%), pap 59 (29.5%), cnf 58 (29%), sfa 50 (25%) and afa 24 (12%).There was significant association between pap gene and urine urgency (p-0.016); sfa and dysuria and urine urgency (p-0.019 and p-0.043 respectively); hly and suprapubic pain (p-0.002); aer and suprapubic pain, flank pain and fever (p-0.017, p-0.040, p-0.029 respectively). Majority of E. coli isolates were phylogroup B2 60(30%) followed by D 55(27.5%), B1 48(24%) and A 37(18.5%). There was significant association between E. coli phylogroup B2 and three virulence genes namely afa, pap, and sfa (p-0.014, p-0.002, p-0.004 respectively). Conclusion: In this study the most frequent E. coli virulence gene was fimH, followed by aer, hly, pap, cnf, sfa and afa respectively. There was significant association between E. coli virulence genes and clinical symptoms of UTI. The phylogenetic analysis indicates majority of uropathogenic E. coli isolates were phylogroup B2 followed by phylogroup D. Phylogroup B2 carries more virulence genes. Hence, targeting major UPEC phylogroup and virulence genes for potential vaccine candidates is essential for better management of UTI and further research has to be conducted in this area.

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“…[19] in South-West Nigeria, Abdu et al . [21] in Maiduguri, Nigeria, and Mokube et al . [8] in Cameroon.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Symptomatic Bacteriuria and Associated Risk Factors among Patients Attending Major Hospitals in Calabar, Nigeria

Bassey,

Mbah,

Akpan

et al. 2023

Preprint

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IntroductionUrinary tract infections (UTIs) are among the most encountered bacterial infection of humans and affect both male and female of all age groups, resulting in high mortality of infected patients if not properly managed.Hypothesis/Gap statementSeveral studies in different sub-Saharan Africa locations show variations in incidence of UTI as well as it’s causative organisms.AimThis study aimed to assess the prevalence, etiological agents, and factors associated with urinary tract infections among patients attending selected hospitals in Calabar metropolis, Nigeria.MethodologyThis was a cross-sectional study. Mid-stream urine samples collected from 240 patients with UTI were cultured using Cystine Lactose Electrolyte Deficient Agar (CLED). Data on socio-demographic, clinical symptoms and risk factors were obtained using structured questionnaire. Uropathogens were characterized using microbiological and biochemical tests and confirmed with API®20E and 20NE (Biomérieux) identification system. Pearson Chi-square was employed to check associations between categorical variables.P-value of <.05 was considered statistically significant.ResultsOut of the 240 urine samples collected, 13 were contaminated during collection, and 227 analyzed. Sixty-five (28.6%) patients had significant bacteriuria. Previous history of UTI (P=.000, CI=1.582-5.180), use of drugs without prescription (P=.000, CI=0.040-0.220), pregnancy (P=.001, CI=1.858-12.575) and history of urinary catheter (P=.031, CI=1.024-19.053) showed significant association with the occurrence of UTI.Klebsiella pneumoniae(23.1%) was the most predominant isolate, followed by Coagulase-negative Staphylococci (16.9%) andEscherichia coli(12.3%).ConclusionThe study shows that routine UTI screening is beneficial for pregnant women, patients with difficult or painful urination, patients with previous episodes of UTI, catheterized patients and appropriate drugs administered for positive cases. In addition, self-administration of antibiotics should be avoided.

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Antibiotic susceptibility patterns of Uropathogenic Escherichia coli among patients with urinary tract infections in a tertiary care hospital in Maiduguri, North Eastern, Nigeria

Cited by 7 publications

References 61 publications

Antibiotic resistance pattern of Escherichia coli isolates from outpatients with urinary tract infections in Somalia

Antibiotic resistance pattern of Escherichia coli isolates from outpatients with urinary tract infections in Somalia

Distribution of virulence genes and phylogenetics of uropathogenic Escherichia coli among urinary tract infection patients in Addis Ababa, Ethiopia

Prevalence of Symptomatic Bacteriuria and Associated Risk Factors among Patients Attending Major Hospitals in Calabar, Nigeria

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