Antibiotic Synthesis and Morphological Differentiation of Cephalosporium acremonium

Nash, C. H.; Huber, F. M.

doi:10.1128/aem.22.1.6-10.1971

Cited by 70 publications

(24 citation statements)

References 3 publications

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“…towards reproduction. It is evident that these cells were observed by NASH and HUBER during the development of a non-antibiotic-producing mutant of Acremonium chrysogenum (NASH et al 1971).…”

Section: Resultsmentioning

confidence: 91%

“…9 The destructed cells of Acrenioniunt chrysogenum deprived of cell walls and cytoplasmic membranes but preserving the form of a cell. (NASH et al 1971). However, this is not appropriate to their structure, since arthrospores are thallome conidia (spores) (GOZLENKO 1981), which means that they are metabolically inactive.…”

Section: Figmentioning

confidence: 99%

“…As well as in many other representatives of deuteromycetes, the manifestation of morphological differentiation in Acremonium chrysogenum is diverse and its development in submerged culture is characterized by rather high polymorphism : long vegetative hyphae, hyphal fragments, arthrospore chains, single arthrospores, conidiophores and conidia (NASH el a/. 1971, BARTOSHEVICH et af. 1983, 1985.…”

mentioning

confidence: 99%

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Acremonium chrysogenum differentiation and biosynthesis of cephalosporin

Bartoshevich

Zaslavskaya

Novak

et al. 1990

J. Basic Microbiol.

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On the basis of structure-functional analysis of the development of Acremonium chrysogenum, e.g. under conditions either stimulating antibiotic synthesis or not conductive to production, a scheme was proposed representing the various ways in which morphological differentiation occurs in the culture in dependence on the directions of its metabolism. Three types of culture differentiation were determined. Type 1 differentiation is characterized by the transition of the vegetative stage into the reproductive one with the formation of conidia. Type 2 differentiation is characterized by the formation of typical arthrospores also being the reproductive form. Type 3 differentiation is characterized by the multistage transformation of the mycelium organization into the yeast-like one which is metabolically more active and is a producer of antibiotics and enzymes. In addition to the defined regularities in the development and differentiation of Acremonium chrysogenum structural peculiarities were observed which could be helpful to the search for regulators or specific enzymes taking part in the culture development.

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Section: Resultsmentioning

confidence: 91%

Section: Figmentioning

confidence: 99%

mentioning

confidence: 99%

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Acremonium chrysogenum differentiation and biosynthesis of cephalosporin

Bartoshevich

Zaslavskaya

Novak

et al. 1990

J. Basic Microbiol.

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“…Cephalosporin production commences in synchrony with the production of arthrospores. When methionine was added, both cephalorporin and arthrospore production were stimulated (Smith et al 1967) The correlation of p-lactam synthesis with the swelling and fragmentation of hyphal fragments was noted also by Nash and Huber (1971). I n a series of mutants of the species, cephalosporin C production was accompanied by the differentation of swollen hyphal fragments to unicellular arthrospores (Queener and Ellis 1975).…”

Section: Correlation Of Secondary Metabolism and Differentation In Fungimentioning

confidence: 98%

Secondary Metabolism as Differentiation

Bennett

1983

Journal of Food Safety

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Secondary metabolism is the biosynthesis, transformation, and degradation of a wide array of natural products. These low molecular weight organic compounds are generally produced at a restricted phase of the life cycle, often in association with differentiated morphological structures. No unified theory to explain the function of secondary metabolism in the producing organism has been accepted, however one hypothesis that has received widespread attention views secondary metabolites as initiatiors or coordinators of spore formation. A review of the literature indicates that there is ample experimental evidence to nullify this hypothesis. Although secondary metabolite production is often correlated with morphological differentiation, it is not the cause of it. Cellular and chemical differentiation can both be comprehended as different aspects of biological diversification, mediated by Darwinian evolutionary forces.

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“…acremonium produces four morphological cell types that represent stages in the growth cycle: hyphae, arthrospores, conidia, and germlings. Morphological differentiation of C. acremonium appears to be related in some way to synthesis of cephalosporin C. The maximum rate of cephalosporin C production coincides with the conversion of hyphal fragments to arthrospores (18,20). The effects of methionine have been investigated extensively with regard to cephalosporin C synthesis (5,15,19).…”

mentioning

confidence: 99%

Changes in Cellular Fatty Acid Composition of Cephalosporium acremonium during Cephalosporin C Production

Sohn

Lee

Koh

et al. 1994

Appl Environ Microbiol

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Cephalosporium acremonium was cultivated in fermentation medium containing sucrose or methyl oleate as a carbon source for cephalosporin C production. The level of antibiotic production was 48 g of cephalosporin C per liter under optimum conditions when methyl oleate was used. The C18:1 (oleic acid) methyl ester appeared to be utilized faster than the C18:2 (linoleic acid) methyl ester in fermentation broth. Physiological characteristics of C. acremonium were investigated by determining the fatty acid composition of the total cellular free lipid. Significant changes in cellular fatty acid composition occurred during inoculum cultivation and fermentation. The percentage of C18:1 increased from 19.1 to 38.5%, but the percentage of C18:2 decreased from 56.7 to 36.1%, and there was an increase in pH during inoculum cultivation. The cellular fatty acid composition of C. acremonium grown in fermentation medium containing methyl oleate (methyl oleate medium) was significantly different from that in fermentation medium containing sucrose (sucrose medium

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Antibiotic Synthesis and Morphological Differentiation of Cephalosporium acremonium

Cited by 70 publications

References 3 publications

Acremonium chrysogenum differentiation and biosynthesis of cephalosporin

Acremonium chrysogenum differentiation and biosynthesis of cephalosporin

Secondary Metabolism as Differentiation

Changes in Cellular Fatty Acid Composition of Cephalosporium acremonium during Cephalosporin C Production

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