Antibiotic therapy: a major cause of drug-induced jaundice in southwest England

Hussaini, S. H.; O'Brien, Ciara S; Despott, Edward J.; Dalton, Harry R.

doi:10.1097/01.meg.0000250581.77865.68

Cited by 83 publications

(61 citation statements)

References 18 publications

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“…Geographical variability is high regarding agents responsible for liver damage (Table I). Most cases in western countries are associated with antibiotics, anticonvulsants, and psychotropic drugs; less than 10% correspond to herbal remedies and dietary supplements, but this proportion has been increasing in the last few years (1,(4)(5)(6)(7)(8). In Asia herbal remedies are a relevant cause of hepatotoxicity (9).…”

Section: Epidemiologymentioning

confidence: 99%

Hepatotoxicity in 2011: advancing resolutely

Lozano-Lanagrán

Robles

Lucena

et al. 2011

Rev. esp. enferm. dig.

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Section: Epidemiologymentioning

confidence: 99%

Hepatotoxicity in 2011: advancing resolutely

Lozano-Lanagrán

Robles

Lucena

et al. 2011

Rev. esp. enferm. dig.

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“…Th e incidence in the general population varies between 1.27 per 100,000 per annum ( 5 ) in rural England to 2.4 per 100,000 person-years in Spain and Sweden ( 2,6 ). Among medical inpatients, the incidence is 1.4 % ( 7 ), whereas in an outpatient setting it is 0.014 % per patient per year ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Single-Center Experience With Drug-Induced Liver Injury From India: Causes, Outcome, Prognosis, and Predictors of Mortality

Devarbhavi

Dierkhising

Kremers

et al. 2010

American Journal of Gastroenterology

209

190

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Although drug-induced liver injury (DILI) is rare, it may result in signifi cant morbidity or death. The causes and outcome vary according to regions, with acetaminophen and complementary medicines common in the West and the Far East, respectively. This study evaluates the causes, outcomes, predictors, and models for 90-day mortality from DILI from India. METHODS:Consecutive patients with DILI from 1997 to 2008 based on International Consensus Criteria from a medical college hospital setting were studied. RESULTS:Of the 313 patients, 58 % were males. Leading causes were a combination of four anti-tuberculous drugs (ATDs) (58 % ), anti-epileptics ( SUPPLEMENTARY MATERIAL is linked to the online version of the paper at

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“…The calculated incidence of amoxicillin-associated hepatotoxicity ranges between 1 and 17 per 100,000 prescriptions [11][12][13].…”

Section: Discussionmentioning

confidence: 99%

Corticosteroid Therapy in a Case of Severe Cholestasic Hepatitis Associated with Amoxicillin–Clavulanate

Herrero‐Herrero

García-Aparicio

2010

J. Med. Toxicol.

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Amoxicillin-clavulanate is the most common drug involved in drug-induced liver injury and the single most frequently prescribed product leading to hospitalization for drug-induced liver disease in Spain. The liver damage most frequently associated with amoxicillinclavulanate is cholestasic type. The latency period between first intake and onset of symptoms is 3-4 weeks on average. A 76-year-old man developed fever, pruritus, and jaundice 3 weeks after having completed treatment with amoxicillin-clavulanate. Liver function tests showed cholestasic hepatitis (up to 50.75 mg/dL of total serum bilirubin level). The ultrasound-guided liver biopsy revealed severe canalicular cholestasis and portal and lobular eosinophilic infiltrates. Prednisone and ursodeoxycholic acid therapy were then prescribed. The patient became symptom-free with normal liver function tests. Amoxicillin-clavulanate can cause hepatocellular, cholestasic, or mixed liver injury. The presence of eosinophilic infiltrates in the liver biopsy and the clinical signs of hypersensitivity in some of the cholestasic cases suggest a pathophysiological immunoallergic mechanism. For this reason, corticosteroid treatment should be considered for patients with severe cholestasic liver injury.

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Antibiotic therapy: a major cause of drug-induced jaundice in southwest England

Cited by 83 publications

References 18 publications

Hepatotoxicity in 2011: advancing resolutely

Hepatotoxicity in 2011: advancing resolutely

Single-Center Experience With Drug-Induced Liver Injury From India: Causes, Outcome, Prognosis, and Predictors of Mortality

Corticosteroid Therapy in a Case of Severe Cholestasic Hepatitis Associated with Amoxicillin–Clavulanate

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