Antibiotic Therapy for 6 or 12 Weeks for Prosthetic Joint Infection

Bernard, Louis; Arvieux, Cédric; Brunschweiler, B.; Touchais, S.; Ansart, Séverine; Bru, J.P.; Oziol, E.; Boéri, Cyril; Gras, Guillaume; Druon, J.; Rosset, Philippe; Senneville, Éric; Bentayeb, H.; Bouhour, D.; Moal, G. Le; Michon, J.; Aumaître, Hugues; Forestier, E.; Laffosse, Jean-Michel; Bégué, Thierry; Chirouze, Catherine; Dauchy, Frédéric‐Antoine; Devaud, Edouard; Benoît, Michel; Burgot, Denis; Boutoille, David; Stindel, Éric; Dinh, Aurélien; Bémer, Pascale; Giraudeau, Bruno; Issartel, B.; Caille, Agnès

doi:10.1056/nejmoa2020198

Cited by 130 publications

(87 citation statements)

References 16 publications

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“…These data provide an additional rationale for reductions in antibiotic use that can disrupt microbial communities and lead to adverse events following antimicrobial treatment. Trials are increasingly examining the efficacy of shorter durations of antibiotic treatment for a range of diseases ( 20 , 30 – 32 ). Future studies of the efficacy and duration of antibacterials should consider the impact on the microbiota and resistome as part of the trial design.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Respiratory Resistomes and Microbiota in Children Receiving Short versus Standard Course Treatment for Community-Acquired Pneumonia

Pettigrew

Kwon

Gent³

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Comparison of the Respiratory Resistomes and Microbiota in Children Receiving Short versus Standard Course Treatment for Community-Acquired Pneumonia

Pettigrew

Kwon

Gent³

et al. 2022

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“…Eine der wenigen prospektiven Studien von Nelson et al zeigte 1993, dass bei Anwendung von lokaler antimikrobieller Therapie eine kürzere systemische Behandlung möglich erscheint [26]. Eine kürzlich veröffentliche prospektive Studie von Bernard et al hingegen betont die Überlegenheit einer 12-wöchigen antimikrobiellen Therapie [27].…”

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Does the Implementation of the PRO-IMPLANT Foundation Treatment Algorithm Improve the Outcome of Chronic Periprosthetic Knee Infections? Mid-Term Results of a Prospective Study

et al. 2021

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Background Several treatment options for chronic periprosthetic joint infections have been published in the current literature, with an on-going discussion to determine effective management algorithms. Objectives To compare outcomes of the two-stage exchange procedure in revision TKA prior to and after implementation of the PRO-IMPLANT Foundation treatment algorithm. The primary endpoints were defined as (i) revisions during the interval time, (ii) duration of the interval time and (iii) successful PJI eradication. Material and Methods Between 02/2013 and 09/2016, 122 patients were included in a single-centre cohort analysis. 55 patients were treated according to the previously used algorithm (K1) and 67 according to the PRO-IMPLANT Foundation algorithm (K2). A minimum follow-up period of 3 years was set as the inclusion criterion. Successful eradication of infection was defined in accordance with the consensus criteria by Diaz-Ledezma et al. Results Successful eradication was achieved in 42 (67%) patients in K1 and 47 (85.5%) in K2 (p ≤ 0.005). The mean interval time was 88 days (range 51 – 353) in K1 and 52 days (range 42 – 126) in K2 (p ≤ 0.005). In K1, a mean of 0.8 (range 0 – 6) revisions were necessary during the interval period compared with 0.5 (range 0 – 4) in K2 (p = 0.066). Conclusion Implementation of the PRO-IMPLANT treatment algorithm led to significant improvement in the outcome of periprosthetic joint infections. During mid-term follow-up, infection eradication was highly successful, with decreases in the interval time as well as the number of revisions.

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“…However, most of them have been performed in a selected group of patients [ 18 ]. In addition, a 6-week treatment showed a worse outcome in a recent randomized trial from France [ 19 ], especially in acute infections treated with DAIR.…”

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confidence: 99%

A protocol for periprosthetic joint infections from the Northern Infection Network for Joint Arthroplasty (NINJA) in the Netherlands

et al. 2022

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Periprosthetic joint infection (PJI) is a devastating complication of joint arthroplasty surgery. Treatment success depends on accurate diagnostics, adequate surgical experience and interdisciplinary consultation between orthopedic surgeons, plastic surgeons, infectious disease specialists and medical microbiologists. For this purpose, we initiated the Northern Infection Network for Joint Arthroplasty (NINJA) in the Netherlands in 2014. The establishment of a mutual diagnostic and treatment protocol for PJI in our region has enabled mutual understanding, has supported agreement on how to treat specific patients, and has led to clarity for smaller hospitals in our region for when to refer patients without jeopardizing important initial treatment locally. Furthermore, a mutual PJI patient database has enabled the improvement of our protocol, based on medicine-based evidence from our scientific data. In this paper we describe our NINJA protocol.Level of evidence: III

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Antibiotic Therapy for 6 or 12 Weeks for Prosthetic Joint Infection

Cited by 130 publications

References 16 publications

Comparison of the Respiratory Resistomes and Microbiota in Children Receiving Short versus Standard Course Treatment for Community-Acquired Pneumonia

Comparison of the Respiratory Resistomes and Microbiota in Children Receiving Short versus Standard Course Treatment for Community-Acquired Pneumonia

Does the Implementation of the PRO-IMPLANT Foundation Treatment Algorithm Improve the Outcome of Chronic Periprosthetic Knee Infections? Mid-Term Results of a Prospective Study

A protocol for periprosthetic joint infections from the Northern Infection Network for Joint Arthroplasty (NINJA) in the Netherlands

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