Antibiotic therapy with metronidazole reduces endometriosis disease progression in mice: a potential role for gut microbiota

Chadchan, Sangappa B.; Cheng, Meng; Parnell, Lindsay A.; Yin, Yin; Schriefer, Andrew E.; Mysorekar, Indira U.; Kommagani, Ramakrishna

doi:10.1093/humrep/dez041

Cited by 126 publications

(133 citation statements)

References 49 publications

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“…No other studies demonstrated associations between inflammatory markers and microbiota. Finally, a recent study found that administration of metronidazole to an endometriotic mouse model resulted in a reduction in the volume of ectopic lesions as well as the magnitude of the inflammatory response …”

Section: Discussionmentioning

confidence: 99%

Endometriosis and the microbiome: a systematic review

Leonardi

Hicks

El‐Assaad

et al. 2019

BJOG

116

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Background The aetiology and pathogenesis of endometriosis are still under investigation. There is evidence that there is a complex bidirectional interaction between endometriosis and the microbiome.Objective To systematically review the available literature on the endometriosis-microbiome interaction, with the aim of guiding future inquiries in this emerging area of endometriosis research.Search strategy MEDLINE, Embase, Scopus and Web of Science were searched through May 2019. A manual search of reference lists of relevant studies was also performed.Selection criteria Published and unpublished literature in any language describing a comparison of the microbiome state in mammalian hosts with and without endometriosis.Data collection and analysis Identified studies were screened and assessed independently by two authors. Data were extracted and compiled in a qualitative synthesis of the evidence.Main results Endometriosis appears to be associated with an increased presence of Proteobacteria, Enterobacteriaceae, Streptococcus spp. and Escherichia coli across various microbiome sites. The phylum Firmicutes and the genus Gardnerella also appear to have an association; however, this remains unclear.Conclusions The complex bidirectional relationship between the microbiome and endometriosis has begun to be characterised by the studies highlighted in this systematic review. Laboratory and clinical studies demonstrate that there are indeed differences in the microbiome composition of hosts with and without endometriosis.

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Section: Discussionmentioning

confidence: 99%

Endometriosis and the microbiome: a systematic review

Leonardi

Hicks

El‐Assaad

et al. 2019

BJOG

116

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“…This inflammatory process found in patients with endometriosis has been described because it is possibly related to the presence of microorganisms. Several authors have shown, for example, an increase in the cytokine IL-1β in patients with endometriosis and they correlate this increase with the activation of inflammasomes by stimulating microorganisms, and also correlate the participation of this event in the pathogenesis of the disease [17][18][19].…”

Section: Introductionmentioning

confidence: 91%

Microbiome Profile of Deep Endometriosis Patients: Comparison of Vaginal Fluid, Endometrium and Lesion

Hernandes

Silveira²,

Sereia³

et al. 2020

Diagnostics

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This work aimed to identify and compare the bacterial patterns present in endometriotic lesions, eutopic endometrium and vaginal fluid from endometriosis patients with those found in the vaginal fluid and eutopic endometrium of control patients. Vaginal fluid, eutopic endometrium and endometriotic lesions were collected. DNA was extracted and the samples were analyzed to identify microbiome by high-throughput DNA sequencing of the 16S rRNA marker gene. Amplicon sequencing from vaginal fluid, eutopic endometrium and endometriotic lesion resulted in similar profiles of microorganisms, composed most abundantly by the genus Lactobacillus, Gardnerella, Streptococcus and Prevotella. No significant differences were found in the diversity analysis of microbiome profiles between control and endometriotic patients; however deep endometriotic lesions seems to present different bacterial composition, less predominant of Lactobacillus and with more abundant Alishewanella, Enterococcus and Pseudomonas.

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“…In fact, prophylactic administration of antibiotics prior to oocyte retrieval in patients suffering from severe endometriosis is today commonly applied due to the risk of infection [123]. In animal models, mice with endometriosis were treated with broad-spectrum antibiotics and it resulted in a reduction of endometriotic lesions, supporting the possible role of microbes in endometriosis progression [131].…”

Section: Antibioticsmentioning

confidence: 99%

“…The hypothesis for the uterine bacterial transmission route originating from the gut exists [30,150], thus FMT was proposed as a promising (future) tool for treatment female reproductive tract diseases [151]. It was shown on broad-spectrum antibiotics-treated endometriosis mice that the FMT from mice with endometriosis resumed the growth of endometriotic lesions suggesting that the gut microbiota could promote endometriosis progression [131]. In humans, differences in gut microbial composition between healthy women and women with endometriosis [152] and polycystic ovary syndrome were reported [153][154][155][156][157][158].…”

Section: Microbial Transplantsmentioning

confidence: 99%

New Opportunities for Endometrial Health by Modifying Uterine Microbial Composition: Present or Future?

et al. 2020

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Current knowledge suggests that the uterus harbours its own microbiota, where the microbes could influence the uterine functions in health and disease; however, the core uterine microbial composition and the host-microbial relationships remain to be fully elucidated. Different studies are indicating, based on next-generation sequencing techniques, that microbial dysbiosis could be associated with several gynaecological disorders, such as endometriosis, chronic endometritis, dysfunctional menstrual bleeding, endometrial cancer, and infertility. Treatments using antibiotics and probiotics and/or prebiotics for endometrial microbial dysbiosis are being applied. Nevertheless there is no unified protocol for assessing the endometrial dysbiosis and no optimal treatment protocol for the established dysbiosis. With this review we outline the microbes (mostly bacteria) identified in the endometrial microbiome studies, the current treatments offered for bacterial dysbiosis in the clinical setting, and the future possibilities such as pro- and prebiotics and microbial transplants for modifying uterine microbial composition.

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Antibiotic therapy with metronidazole reduces endometriosis disease progression in mice: a potential role for gut microbiota

Cited by 126 publications

References 49 publications

Endometriosis and the microbiome: a systematic review

Endometriosis and the microbiome: a systematic review

Microbiome Profile of Deep Endometriosis Patients: Comparison of Vaginal Fluid, Endometrium and Lesion

New Opportunities for Endometrial Health by Modifying Uterine Microbial Composition: Present or Future?

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