Antibiotic tolerance and degradation capacity of the organic pollutant-degrading bacterium Rhodococcus biphenylivorans TG9T

Yu, Chungui; Armengaud, Jean; Blaustein, Ryan A.; Chen, Kezhen; Yang, Zhe; Xu, Fengjun; Gaillard, Jean‐Charles; Qin, Zhihui; Fu, Yulong; Hartmann, Erica M.; Shen, Chaofeng

doi:10.1016/j.jhazmat.2021.127712

Cited by 11 publications

(2 citation statements)

References 62 publications

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“…Moreover, when exposed to antibiotics, Rhodococcus spp. may go into a viable but non-culturable state with restricted metabolic activity and function ( Yu et al, 2022a ).…”

Section: Biodegradation Of Pharmaceutical Pollutantsmentioning

confidence: 99%

“…Thus, for example, norfloxacin-exposed rhodococci entered the dormant state accompanied by a thickened cell wall and an increased roughness at the morphometric level. While at the metabolic and functional levels, errors during DNA replication, subsequent homologous DNA repair (as evidenced by the increased content of repair proteins RecA, uvrA, UvrB, and UvrC in dormant forms), suppression of transporter proteins, ATP production, and the tricarboxylic acid cycle were observed ( Jia et al, 2020b ; Yu et al, 2022a ). Given the simultaneous presence of many pollutants in the environment, bacterial adaptation to antibiotics reduces the degradation efficiency of other priority pollutants.…”

Section: Biodegradation Of Pharmaceutical Pollutantsmentioning

confidence: 99%

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Rhodococcus strains as a good biotool for neutralizing pharmaceutical pollutants and obtaining therapeutically valuable products: Through the past into the future

2022

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Active pharmaceutical ingredients present a substantial risk when they reach the environment and drinking water sources. As a new type of dangerous pollutants with high chemical resistance and pronounced biological effects, they accumulate everywhere, often in significant concentrations (μg/L) in ecological environments, food chains, organs of farm animals and humans, and cause an intense response from the aquatic and soil microbiota. Rhodococcus spp. (Actinomycetia class), which occupy a dominant position in polluted ecosystems, stand out among other microorganisms with the greatest variety of degradable pollutants and participate in natural attenuation, are considered as active agents with high transforming and degrading impacts on pharmaceutical compounds. Many representatives of rhodococci are promising as unique sources of specific transforming enzymes, quorum quenching tools, natural products and novel antimicrobials, biosurfactants and nanostructures. The review presents the latest knowledge and current trends regarding the use of Rhodococcus spp. in the processes of pharmaceutical pollutants’ biodegradation, as well as in the fields of biocatalysis and biotechnology for the production of targeted pharmaceutical products. The current literature sources presented in the review can be helpful in future research programs aimed at promoting Rhodococcus spp. as potential biodegraders and biotransformers to control pharmaceutical pollution in the environment.

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“…Moreover, when exposed to antibiotics, Rhodococcus spp. may go into a viable but non-culturable state with restricted metabolic activity and function ( Yu et al, 2022a ).…”

Section: Biodegradation Of Pharmaceutical Pollutantsmentioning

confidence: 99%

Section: Biodegradation Of Pharmaceutical Pollutantsmentioning

confidence: 99%