Antibiotic Treatment during Gestation Enhances Susceptibility to Mycobacterium tuberculosis in Offspring

Nyangahu, Donald D.; Plumlee, Courtney R.; Brown, Bryan P.; Feng, Colin; Havyarimana, Enock; Cohen, Sara; Urdahl, Kevin B.; Jaspan, Heather B.

doi:10.1128/spectrum.02491-22

Cited by 4 publications

(3 citation statements)

References 51 publications

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“…Continuous light exposure [ 87 ] and pathogen exposure [ 88 ] could have impacted plasma and secretory IgA concentrations. Treatment with antibiotics can decrease IgA concentrations and lead to IgA deficiency with long-term broad spectrum antibiotic use [ 89 ] but not with the short-term use of antibiotics similar to the treatment applied in this study [ 90 , 91 ]. In line, the d48 PIgA concentrations in experiment 1 and 2 were very similar ( Figure 1 ), suggesting that these two factors might not have impacted PIgA concentrations at time of sampling.…”

Section: Discussionmentioning

confidence: 99%

Measuring Chronic Stress in Broiler Chickens: Effects of Environmental Complexity and Stocking Density on Immunoglobulin-A Levels

Campbell

Anderson

Jacobs

2023

Animals

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Commercial housing conditions may contribute to chronic negative stress in broiler chickens, reducing their animal welfare. The objective of this study was to determine how secretory (fecal) and plasma immunoglobulin-A (IgA) levels in fast-growing broilers respond to positive and negative housing conditions. In three replicated experiments, male Ross 708 broilers (n = 1650/experiment) were housed in a 2 × 2 factorial study of high or low environmental complexity and high or low stocking density. In experiments 1 and 3 but not in experiment 2, high complexity tended to positively impact day 48 plasma IgA concentrations. When three experiments were combined, high complexity positively impacted day 48 plasma IgA concentrations. Stocking density and the complexity × density interaction did not impact day 48 plasma IgA concentrations. Environmental complexity and the complexity × density interaction did not impact day 48 secretory IgA concentrations. A high stocking density negatively impacted day 48 secretory IgA concentrations overall but not in individual experiments. These results suggest that environmental complexity decreased chronic stress, while a high stocking density increased chronic stress. Thus, plasma IgA levels increased under high-complexity housing conditions (at day 48), and secretory IgA levels (at day 48) decreased under high-density conditions, suggesting that chronic stress differed among treatments. Therefore, these measures may be useful for quantifying chronic stress but only if the statistical power is high. Future research should replicate these findings under similar and different housing conditions to confirm the suitability of IgA as a measure of chronic stress in broiler chickens.

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Section: Discussionmentioning

confidence: 99%

Measuring Chronic Stress in Broiler Chickens: Effects of Environmental Complexity and Stocking Density on Immunoglobulin-A Levels

Campbell

Anderson

Jacobs

2023

Animals

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“…Primers were removed by Cutadapt using default parameters. Sequences were then imported into R and processed using the DADA2 pipeline as previously described ( 57 ). Briefly, the pipeline performs quality checks and filtering, learns error rates, merges paired-end reads, constructs an ASVs table, removes chimeric sequences, and assigns taxonomy to ASVs using the Silva (v138 release) reference database.…”

Section: Methodsmentioning

confidence: 99%

Bifidobacterium infantis associates with T cell immunity in human infants and is sufficient to enhance antigen-specific T cells in mice

Nyangahu,

Happel,

Wendoh

et al. 2023

Sci. Adv.

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Bacille Calmette-Guerin (BCG) vaccine can elicit good T H 1 responses in neonates. We hypothesized that the pioneer gut microbiota affects vaccine T cell responses. Infants who are HIV exposed but uninfected (iHEU) display an altered immunity to vaccination. BCG-specific immune responses were analyzed at 7 weeks of age in iHEU, and responses were categorized as high or low. Bifidobacterium longum subsp. infantis was enriched in the stools of high responders, while Bacteroides thetaiotaomicron was enriched in low responders at time of BCG vaccination. Neonatal germ-free or SPF mice orally gavaged with live B. infantis exhibited significantly higher BCG-specific T cells compared with pups gavaged with B. thetaiotaomicron. B. infantis and B. thetaiotaomicron differentially affected stool metabolome and colonic transcriptome. Human colonic epithelial cells stimulated with B. infantis induced a unique gene expression profile versus B. thetaiotaomicron . We thus identified a causal role of B. infantis in early-life antigen-specific immunity.

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“…Fecal microbiota transplantation (FMT) in Pseudomonas aeruginosa-infected mice restores intestinal microbial abundance and diversity, suppresses inflammation and tissue damage, and improves Treg/Th17 cell immune balance [10]. Following antibiotic treatment during pregnancy, neonatal mice inoculated with bacillus Calmette-Guérin did not show alterations in the number of TB10.4 T cell epitopes, suggesting that maternal antibiotic use during pregnancy may contribute to the development of immune defects and alter offspring susceptibility to Mycobacterium tuberculosis [11].…”

Section: Infectious Diseases Of the Lungsmentioning

confidence: 99%

The Clinical Progress of the Combined Treatment of Lung and Intestine on Immune Response

Zhang,

Xiao,

Wan

2024

J Clin Med Res

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Lung-intestinal homoeopathy is a comprehensive therapeutic strategy that combines traditional theories of traditional Chinese medicine and modern medical concepts. We review the clinical progress of lung-gut homoeopathy on immune function. aiming to positively affect the immune function of patients with lung diseases. By regulating the intestinal microbiota, influencing intestinal mucosal immunity, and modulating immune mediators, some clinical treatments has been proved to be effective. In addition, lung-intestinal homoeopathy can improve the immune function of patients with lung diseases by regulating the expression of immunity and immune mediators in the intestinal mucosa and influencing the play of immune response. Although lung-intestinal homoeopathy has made some progress in the regulation of immune function, further clinical studies are needed to verify its efficacy and safety.

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Antibiotic Treatment during Gestation Enhances Susceptibility to Mycobacterium tuberculosis in Offspring

Cited by 4 publications

References 51 publications

Measuring Chronic Stress in Broiler Chickens: Effects of Environmental Complexity and Stocking Density on Immunoglobulin-A Levels

Measuring Chronic Stress in Broiler Chickens: Effects of Environmental Complexity and Stocking Density on Immunoglobulin-A Levels

Bifidobacterium infantis associates with T cell immunity in human infants and is sufficient to enhance antigen-specific T cells in mice

The Clinical Progress of the Combined Treatment of Lung and Intestine on Immune Response

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