2021
DOI: 10.1101/2021.07.30.454300
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Antibiotic treatment induces activation of microglia and impairment of cholinergic gamma oscillations in the hippocampus

Abstract: Antibiotics are widely applied for the treatment of bacterial infections, but their long-term use may lead to gut flora dysbiosis and detrimental effects on brain physiology, behavior as well as cognitive performance. Still, a striking lack of knowledge exists concerning electrophysiological correlates of antibiotic-induced changes in gut microbiota and behavior. Here, we investigated changes in the synaptic transmission and plasticity together with behaviorally-relevant network activities from the hippocampus… Show more

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