2020
DOI: 10.1016/j.infpip.2020.100078
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Antibiotic use among surgical inpatients at a tertiary health facility: a case for a standardized protocol for presumptive antimicrobial therapy in the developing world

Abstract: Summary Background Indiscriminate antimicrobial use is one of the greatest contributors to antimicrobial resistance. A low level of asepsis in hospitals and inadequate laboratory support have been adduced as reasons for indiscriminate use of antimicrobials among surgical patients. At present, there are no guidelines for presumptive antibiotic use in Nigeria and sub-Saharan Africa. Aim Surgical inpatients at the study hospital were surveyed to determine the … Show more

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Cited by 15 publications
(17 citation statements)
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References 19 publications
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“…The most common use for which patients were prescribed antibiotics was for prophylaxis (47%), followed by empirical therapy (44%), as most cases had undergone surgical intervention. The findings were similar to studies conducted in India and Nigeria (3,11) . Of the 1085 antibiotics prescribed, 96.13% were injectables, which was found to be higher when compared to a study in Nigeria, where only 58.7% of antibiotics were injectables.…”
Section: Resultssupporting
confidence: 89%
See 1 more Smart Citation
“…The most common use for which patients were prescribed antibiotics was for prophylaxis (47%), followed by empirical therapy (44%), as most cases had undergone surgical intervention. The findings were similar to studies conducted in India and Nigeria (3,11) . Of the 1085 antibiotics prescribed, 96.13% were injectables, which was found to be higher when compared to a study in Nigeria, where only 58.7% of antibiotics were injectables.…”
Section: Resultssupporting
confidence: 89%
“…Of the 1085 antibiotics prescribed, 96.13% were injectables, which was found to be higher when compared to a study in Nigeria, where only 58.7% of antibiotics were injectables. This difference might be due to the following study design, i.e., point prevalence survey (11) . The characteristics of antibiotic prescriptions in the study population are depicted in Table 2.…”
Section: Resultsmentioning
confidence: 99%
“…Ethical clearance for the conduct of the study was obtained from the various local research and ethics committees of the participating hospitals. There was no direct contact with patients, and no identifiers such as name, phone number and address were among these Nigerian hospitals is similar to the high rates reported in other studies in Nigeria and other tropical countries (12,14,15). This could be as a result of the generally low awareness on appropriate antibiotic use and AMR, high over-the-counter use of antibiotics, low level of implementation of AMS programmes such as awareness campaigns in the regions and lack of stringent guidelines and policy for AMU.…”
Section: Ethical Considerationsupporting
confidence: 82%
“…The health system has not identified AMS as a priority, hence the absence of policy and lack of resource allocation. This level of practice could explain the high level of antimicrobial use earlier reported in some Nigerian hospitals (Nnadozie, et al, 2020;Umeokonkwo, et al, 2019;Oduyebo, et al, 2017;Abubakar, 2020).…”
Section: Discussionmentioning
confidence: 86%