Antibiotic use in food animals worldwide, with a focus on Africa: Pluses and minuses

Van, Thi Thu Hao; Yidana, Zuwera; Smooker, Peter M.; Coloe, Peter J.

doi:10.1016/j.jgar.2019.07.031

Cited by 311 publications

(218 citation statements)

References 101 publications

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“…The use of various antimicrobials as growth promoters in veterinary medicine has been regulated in developed countries, but in Pakistan, antibiotics are still widely administered for therapeutic purposes and growth promotion in poultry [9,10]. A recent study suggested the extensive annual administration up to 568 tons of various antimicrobials in the poultry industry of Pakistan [10].…”

Section: Introductionmentioning

confidence: 99%

Next-Generation Sequencing Based Gut Resistome Profiling of Broiler Chickens Infected with Multidrug-Resistant Escherichia coli

Afridi

Ali

Chang

2020

Animals

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The study was designed to investigate the fecal microbiome and resistome of broiler chickens infected with multidrug-resistant (MDR) Escherichia coli (E. coli). Fecal samples (n = 410) from broiler chickens were collected from thirteen randomly selected sites of Khyber Pakhtunkhwa and screened for the presence of MDR E. coli. Upon initial screening, thirteen (13) MDR E. coli isolates were then subjected to shotgun metagenome next-generation sequencing (NGS). NGS based resistome analysis identified the multidrug efflux pump system-related genes at the highest prevalence (36%) followed by aminoglycoside (26.1%), tetracycline (15.9%), macrolide-lincosamide-streptogramin (9.6%), beta-lactam (6.6%), rifampin (2%), sulphonamide (1.3%), phenicol (0.91%), vancomycin (0.62%), trimethoprim (0.34%), colistin (0.30%), and quinolone (0.33%). The most abundant virulence-associated genes (VAGs) identified were iroN, iutA, iss, and iucA. NGS based taxonomic profiling at the phylum level revealed the predominance of Proteobacteria (38.9%) followed by Firmicutes (36.4%), Bacteroidetes (15.8%), and Tenericutes (8.9%). Furthermore, pathobionts such as E. coli, Salmonella enterica, Klebsiella pneumoniae, and Shigella flexneri belonging to the family Enterobacteriaceae were predominantly found. This study revealed the widespread presence of MDR genes, diverse VAGs, and a dysbiotic gut in the broiler chickens infected with MDR E. coli of Khyber Pakhtunkhwa for the first time using NGS.

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Section: Introductionmentioning

confidence: 99%

Next-Generation Sequencing Based Gut Resistome Profiling of Broiler Chickens Infected with Multidrug-Resistant Escherichia coli

Afridi

Ali

Chang

2020

Animals

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“…With low awareness and knowledge on antibiotics, this practice can facilitate antibiotic resistance. 25 - 27 As such, relevant stakeholders in antibiotic management (such as local veterinarians) should raise awareness on proper use of antibiotics in agriculture. Relevant information could include the need to use recommended dosages, recommended administration of antibiotics, and to not combine several antibiotics if not necessary.…”

Section: Discussionmentioning

confidence: 99%

Understanding Antibiotic Residues and Pathogens Flow in Wastewater from Smallholder Pig Farms to Agriculture Field in Ha Nam Province, Vietnam

Pham-Duc

Nguyen-Viet

Luu-Quoc

et al. 2020

Environ�Health�Insights

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Background: Contact with livestock wastewater on farms and in communities can pose a risk to human and animal health. Methods: This cross-sectional study was conducted in 180 households and 24 pig farms (96 wastewater samples) to explore information about pig production, livestock waste management, antibiotic use, and to analyze antibiotic residues and microbial contamination, respectively. Results: Of the 120 households raising pigs, biogas systems were the most commonly used to treat animal waste (70%), followed by compositing (19%), and the remaining respondents discharged waste directly into drains or ponds (11%). The majority of respondents (78%) used antibiotics to treat and prevent disease in pigs, but 32% of them did not know of any disadvantages of antibiotic abuse. ELISA assays were performed on half of the wastewater samples (n = 48), demonstrating that residues of flouroquinolones and sulfonamides were present in 6.3% (3/48) and 22.9% (11/48) of tested samples, respectively. The average residual level of sulfamethazine was 27.8 ug/l. Further, E. coli concentrations exceeding regulatory levels in Vietnam were found in nearly all samples. Salmonella spp. was also found in 57.3% of samples, though prevalence rates varied across the different sites. Finally, G. lamblia was found in 8.4% of samples, and C. parvum was found in 5.2% of samples. Conclusions: This study suggests that livestock wastewater carried potential harmful pathogens and antibiotic residues that could come into contact with humans in the community. Thus, appropriate operation and application of livestock wastewater treatment (such as biogas or composting) and management should be a continued focused.

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“…62,63 Those extensively available veterinary antimicrobial drugs procured over the counter in several African states are contributing to the rise of cross resistant bacteria in human or conversely from human to animals. 64 It has been shown that AMR bacteria from humans, who have not taken the drug, was found but initially detected in animal products like meat and milk. There may not be fundamental evidence but the spread of resistant bacterial strains among human and animals adds difficulties in antibiotic use in future veterinary or medical fields.…”

Section: Phage Therapy In Veterinary Sciencementioning

confidence: 99%

Bacteriophages Against Pathogenic Bacteria and Possibilities for Future Application in Africa

Kassa¹

2021

IDR

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Antibiotic use in food animals worldwide, with a focus on Africa: Pluses and minuses

Cited by 311 publications

References 101 publications

Next-Generation Sequencing Based Gut Resistome Profiling of Broiler Chickens Infected with Multidrug-Resistant Escherichia coli

Next-Generation Sequencing Based Gut Resistome Profiling of Broiler Chickens Infected with Multidrug-Resistant Escherichia coli

Understanding Antibiotic Residues and Pathogens Flow in Wastewater from Smallholder Pig Farms to Agriculture Field in Ha Nam Province, Vietnam

Bacteriophages Against Pathogenic Bacteria and Possibilities for Future Application in Africa

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