1999
DOI: 10.1016/s0002-9378(99)70307-8
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Antibiotic use in pregnancy and drug-resistant infant sepsis

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Cited by 104 publications
(55 citation statements)
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“…The incidence of ␤-lactam-resistant gram-negative neonatal sepsis appears to be increasing (9,15,18,20,35,36). It has been suggested that this increase is due to the widespread use of penicillin or aminopenicillin, the first-line recommended agents for IAP to prevent GBS disease.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The incidence of ␤-lactam-resistant gram-negative neonatal sepsis appears to be increasing (9,15,18,20,35,36). It has been suggested that this increase is due to the widespread use of penicillin or aminopenicillin, the first-line recommended agents for IAP to prevent GBS disease.…”
Section: Discussionmentioning
confidence: 99%
“…A retrospective cohort study by Schrag et al showed that IAP significantly reduces the incidence of early-onset GBS infection (29). However, some authors have suggested that this GBS prevention policy may also have adverse effects, such as an increased incidence of neonatal infections caused by pathogens other than GBS, including ␤-lactam-resistant strains (9,15,18,20,35,36). Some studies have investigated the effects of antimicrobial agents on human flora (34).…”
mentioning
confidence: 99%
“…Most studies on antimicrobial susceptibility of GBS strains have found uniform susceptibility to penicillin (1,2,10,16,19,22,30,31), although increased resistance to ampicillin, in particular as a result of ante-and intrapartum treatment with this agent, has been described (18). However, Vermillion et al (32), in a study of 574 GBS isolates collected from an obstetric population in the United States in 1998, reported 1.8% of strains with nonsusceptibility to penicillin; MIC levels were not reported.…”
Section: Discussionmentioning
confidence: 99%
“…In fact, the association of the two antibiotics used in this study is known to be synergistic and bactericidal in vitro (16). The choice of a broad-spectrum cephalosporin (representing firstline therapy today) was based on the current increase in penicillinase-secreting E. coli strains (29). Ceftriaxone was preferred to cefotaxime for practical reasons, as its binding to rabbit serum proteins is similar to that in humans (11,18).…”
Section: Discussionmentioning
confidence: 99%