2017
DOI: 10.1371/journal.pone.0177435
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Antibiotic use in South Korea from 2007 to 2014: A health insurance database-generated time series analysis

Abstract: BackgroundInappropriate antibiotic use significantly contributes to antibiotic-resistance, resulting in reduced antibiotic efficacy and increasing physical burden and cost of disease. The goal of this study was to explore antibiotic usage patterns in South Korea using 2007–2014 health insurance claims data.MethodsWe used the Health Insurance Review & Assessment Service data, which represents nearly the entire population of South Korea, to discern patterns in antibiotic prescribing practices. The daily dose, as… Show more

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Cited by 32 publications
(38 citation statements)
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“…In particular, the use (DDD/1,000 patients/day) of cefpodoxime, a third‐generation cephalosporin, increased twofold from 2010 to 2014. This is in line with previous studies that noted increases in the use of third‐generation cephalosporins in Korea . These broad spectrum antibiotics are usually recommended for inpatients with community‐acquired pneumonia, but there is no clear explanation as to why the use of third‐generation cephalosporins increased in the outpatient setting; we cannot rule out, however, the possibility of strong sales and promotion of newer antibiotics by the pharmaceutical industry.…”
Section: Discussionsupporting
confidence: 88%
“…In particular, the use (DDD/1,000 patients/day) of cefpodoxime, a third‐generation cephalosporin, increased twofold from 2010 to 2014. This is in line with previous studies that noted increases in the use of third‐generation cephalosporins in Korea . These broad spectrum antibiotics are usually recommended for inpatients with community‐acquired pneumonia, but there is no clear explanation as to why the use of third‐generation cephalosporins increased in the outpatient setting; we cannot rule out, however, the possibility of strong sales and promotion of newer antibiotics by the pharmaceutical industry.…”
Section: Discussionsupporting
confidence: 88%
“…The H. pylori eradication rates with quinolone‐containing regimens in Korea have been disappointing in terms of first‐line or third‐line therapies . Quinolone usage based on Korean insurance data was increased from 2007 to 2014, but these antibiotics seem now to be inappropriate as a first‐line H. pylori eradication regimen.…”
Section: Discussionmentioning
confidence: 99%
“…During the interviews, ID physicians also expressed that ID consults were sometimes disregarded and were requested late. Unfortunately, this meant that ID consults were often pointless (phy6- [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. ID physicians believed that their roles were limited in the approval of restricted antimicrobial agents.…”
Section: Conflicts Over Primary Responsibility and Scopes Of Practicementioning
confidence: 99%
“…ⓐProspective audit with direct intervention and feedback (7,3) ⓒEducation (0,3) ⓓEvidence-based guidelines and clinical pathways (1,1) ⓔAntimicrobial cycling (0,1) ⓕAntimicrobial order forms (0,1) ⓖCombination therapy (0,2) ⓗStreamlining or de-escalation of therapy (5,4) ⓘDose optimization (3,2) ⓙParenteral-to-oral conversion (2,3)…”
Section: Physician Perspectives (N=11)mentioning
confidence: 99%
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