Antibiotics and bioactive natural products in treatment of methicillin resistant Staphylococcus aureus: A brief review

Kali, Arunava

doi:10.4103/0973-7847.156329

Cited by 77 publications

(50 citation statements)

References 42 publications

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“…Hence, the plants with huge diversity provide a vast source for exploration of anti-MRSA phytochemicals. In vitro Anti-MRSA activity of crude extracts of medicinal plants has been extensively reported [148]. Various phytochemicals such as β-asarone, Mansonone F, prenylated flavonoids and thymoquinone showed in vitro anti-MRSA activity [149][150][151][152].…”

Section: Plantsmentioning

confidence: 99%

Staphylococcus aureus: Overview of Bacteriology, Clinical Diseases, Epidemiology, Antibiotic Resistance and Therapeutic Approach

Gnanamani¹,

Periasamy²,

Paul‐Satyaseela³

2017

Frontiers in Staphylococcus Aureus

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Staphylococcus aureus is an important human pathogen that causes wide range of infectious conditions both in nosocomial and community settings. The Gram-positive pathogen is armed with battery of virulence factors that facilitate to establish infections in the hosts. The organism is well known for its ability to acquire resistance to various antibiotic classes. The emergence and spread of methicillin-resistant S. aureus (MRSA) strains which are often multi-drug resistant in hospitals and subsequently in community resulted in significant mortality and morbidity. The epidemiology of MRSA has been evolving since its initial outbreak which necessitates a comprehensive medical approach to tackle this pathogen. Vancomycin has been the drug of choice for years but its utility was challenged by the emergence of resistance. In the last 10 years or so, newer anti-MRSA antibiotics were approved for clinical use. However, being notorious for developing antibiotic resistance, there is a continuous need for exploring novel anti-MRSA agents from various sources including plants and evaluation of non-antibiotic approaches.

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Section: Plantsmentioning

confidence: 99%

Staphylococcus aureus: Overview of Bacteriology, Clinical Diseases, Epidemiology, Antibiotic Resistance and Therapeutic Approach

Gnanamani¹,

Periasamy²,

Paul‐Satyaseela³

2017

Frontiers in Staphylococcus Aureus

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“…There are a few reports on the use of medicinal plants against MRSA infections includes Triphala, Camellia sinensis (tea), Azadirachta indica (neem), Holarrhena antidysenterica (Kurachi) bark, Delonix regia (Gulmohar) flowers, Punica granatum (Pomegranate), Hemidesmus indicus (Anantamul) stem, and Plumbago zeylanica (Chitra) [14]. Antibiofilm activities of medicinal plants were poorly studied in India.…”

Section: Inermismentioning

confidence: 99%

Antibacterial and anti-biofilm activities of crude extracts of Lawsonia inermis against Methicillin Resistant Staphylococcus aureus

Triveni

Mendem

Shivannavar

et al. 2016

Asian J Pharm Clin Res

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Objective: The continuous rise in the prevalence of multidrug resistance pathogens globally is threatening the treatment and management of infectious diseases. Ethnomedicine plays a key role in the exploration for novel bioactive compounds. The present study evaluates the antibacterial and antibiofilm activities of the crude extracts of Lawsonia inermis against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA).Methods: Shade dried and finely powdered leaves of the plant were extracted by maceration method using six solvents: Methanol, acetone, ethyl acetate, chloroform, petroleum ether, and n-hexane. Antibacterial and antibiofilm activities of the extracts against multidrug-resistant (MDR) MRSA by agar cup diffusion and tube method, respectively. Results:Methanol extract showed the highest antibacterial activity of 18 mm compared to other extracts. Similarly, petroleum ether extract showed the highest biofilm inhibition of 84.7%. Other solvent extracts also exhibited significant biofilm inhibition [n-hexane-83.6%, ethyl acetate-79.5%, chloroform-79.2%, acetone-77%, and methanol-77%]. Conclusion:The leaf extracts of L. inermis have shown promising biofilm inhibitory activity and good antibacterial activity, which can be explored for the development of new drugs for the MDR pathogens.

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“…). Infections caused by MRSA are associated with increased mortality and morbidity, aggressive course, multiple drug resistance and hospital outbreaks, which has become a major public health concern (Kali ). Conventional anti‐MRSA antibiotics like vancomycin, teicoplanin, linezolid and daptomycin are currently in clinical use.…”

Section: Introductionmentioning

confidence: 99%

Mechanism of synergy between SIPI-8294 and β-lactam antibiotics against methicillin-resistant Staphylococcus aureus

Shao

Liu

et al. 2016

Letters in Applied Microbiology

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This study is the first report on the mechanism of synergy between SIPI-8294 and β-lactams against MRSA on the molecular level. In this study, SIPI-8294 showed strong synergistic effects on β-lactam antibiotics both in vitro and in vivo owing to inhibiting mecA expression. As pivotal regulatory genes of mecA, mecR1 and mecI do not participate in SIPI-8294-mecA pathway and are not involved in the synergism of SIPI-8294 and β-lactams. The research indicates that it may be a promising strategy for combating MRSA infections with the combinations of SIPI-8294 and β-lactams. The research is important for structure modification and new drug development.

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Antibiotics and bioactive natural products in treatment of methicillin resistant Staphylococcus aureus: A brief review

Cited by 77 publications

References 42 publications

Staphylococcus aureus: Overview of Bacteriology, Clinical Diseases, Epidemiology, Antibiotic Resistance and Therapeutic Approach

Staphylococcus aureus: Overview of Bacteriology, Clinical Diseases, Epidemiology, Antibiotic Resistance and Therapeutic Approach

Antibacterial and anti-biofilm activities of crude extracts of Lawsonia inermis against Methicillin Resistant Staphylococcus aureus

Mechanism of synergy between SIPI-8294 and β-lactam antibiotics against methicillin-resistant Staphylococcus aureus

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