Antibiotics and Obesity—A Burgeoning or Thinning Argument?

Scott, Frank I.; Mamtani, Ronac

doi:10.1001/jamapediatrics.2016.4032

Cited by 9 publications

(2 citation statements)

References 16 publications

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“…Another factor that may influence the development of pediatric obesity is exposure to antibiotics in early stages of life [108–110]. During infancy, which is the window of time before a stable microbial community has developed, the microbiota seems to have increased susceptibility to perturbations [111].…”

Section: Reviewmentioning

confidence: 99%

Obesity and microbiota: an example of an intricate relationship

et al. 2017

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It is widely accepted that metabolic disorders, such as obesity, are closely linked to lifestyle and diet. Recently, the central role played by the intestinal microbiota in human metabolism and in progression of metabolic disorders has become evident. In this context, animal studies and human trials have demonstrated that alterations of the intestinal microbiota towards enhanced energy harvest is a characteristic of the obese phenotype. Many publications, involving both animal studies and clinical trials, have reported on the successful exploitation of probiotics and prebiotics to treat obesity. However, the molecular mechanisms underlying these observed anti-obesity effects of probiotics and prebiotic therapies are still obscure. The aim of this mini-review is to discuss the intricate relationship of various factors, including diet, gut microbiota, and host genetics, that are believed to impact on the development of obesity, and to understand how modulation of the gut microbiota with dietary intervention may alleviate obesity-associated symptoms.

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Section: Reviewmentioning

confidence: 99%

Obesity and microbiota: an example of an intricate relationship

et al. 2017

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“…Obesity has reached epidemic proportions in the developed world, with one in three children in the United States considered overweight or obese. 1 It is estimated that 8.1% of infants and toddlers and 16.9% between the age of 2 to 19 years have a body mass index (BMI) greater than the 85th percentile, 2 making it one of the greatest public health threats in the country. South Bronx, a socially disadvantaged and medically underserved area in New York City, is known to have some of the highest burdens of various medical conditions and a much higher prevalence of obesity (47%) 3 among children and adolescents compared with a national rate of 19.7%.…”

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confidence: 99%

Neonatal Ampicillin/Gentamicin Exposure and the Risk of Childhood Obesity in South Bronx Pediatric Population

Awujoola,

Torga,

Abdul Ghayum

et al. 2023

Am J Perinatol

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Objective This study aimed to assess the association between neonatal antibiotic exposure and the risk of childhood obesity. Study Design This retrospective cohort study enrolled neonates born between 2011 and 2015 and followed up until 5 years. The incidence of obesity at 5 years old, and other characteristics were compared between the antibiotic-exposed and unexposed groups. Chi-square test was conducted on categorical variables and Student's t-test for normally distributed continuous variable. Significant variables (p < 0.05) in bivariate analysis were modelled in a stepwise multivariate logistic regression analysis to ascertain independent predictors of obesity at 5 years. Results Of the 1,447 subjects, 749 (51.8%) received ampicillin and gentamicin, and 333 (23%) were obese. Neonates exposed to antibiotics were more likely to be obese compared with those unexposed (26 vs. 20%, p = 0.01). In the adjusted model, this association persisted (adjusted odds ratio: 1.37, p = 0.02). Conclusion Neonatal antibiotic exposure is associated with early childhood obesity and may play a significant role in the weight trajectories of these children. Hence, antibiotic stewardship in this period cannot be overemphasized. Key Points

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