Antibiotics and the Ribosome

Abstract

Originally published in: Protein Crystallography in Drug Discovery. Edited by Robert E. Babine and Sherin S. Abdel‐Meguid. Copyright © 2004 Wiley‐VCH Verlag GmbH & Co. KGaA Weinheim. Print ISBN: 3‐527‐30678‐7 The sections in this article are Introduction The Ribosome Introduction Binding of tRNA Peptidyl Transferase Activity Structure of the Ribosome Antibiotics Introduction Antibiotics that Bind to the 50S Subunit MLS B Antibiotics Macrolides Macrolides, 15‐ and 16‐Membered Binding Interactions Between the Lactone Ring and the Ribosome Sugar Interactions with the Ribosome A Covalent Bond Macrolides, 14‐Membered Rational Drug Design of Macrolides Lincosamides Streptogramins Chloramphenicol Nucleoside Analogue Antibiotics Puromycin Aminoacyl‐4‐aminohexosyl‐cytosine Antibiotics Other Antibiotics that Bind to the 50S Subunit Sparsomycin Anisomycin Prospects for Rational Drug Design of Antibiotics that Bind to the Ribosome Acknowledgments