Antibiotics as deep modulators of gut microbiota: between good and evil

Ianiro, Gianluca; Tilg, Herbert; Gasbarrini, Antonio

doi:10.1136/gutjnl-2016-312297

Cited by 534 publications

(406 citation statements)

References 154 publications

(118 reference statements)

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“…Experimental evidence indicates that the human intestinal microbiome can influence tumor development and progression in the gastrointestinal tract by damaging DNA, activating oncogenic signaling pathways, producing tumor‐promoting metabolites, and suppressing the antitumor immune response 7, 25, 26, 27, 28, 29. As the gastrointestinal microbiota can be modified through the rational deployment of antibiotics, probiotics, and prebiotics,30, 31, 32 a better understanding of the relationship between human cancer and the microbiome may have clinical implications.…”

Section: Introductionmentioning

confidence: 99%

Review of the gut microbiome and esophageal cancer: Pathogenesis and potential clinical implications

Baba

Iwatsuki

Yoshida

et al. 2017

Annals of Gastroent Surgery

104

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Esophageal cancer ranks among the most aggressive malignant diseases. The limited improvements in treatment outcomes provided by conventional therapies have prompted us to seek innovative strategies for treating this cancer. More than 100 trillion microorganisms inhabit the human intestinal tract and play a crucial role in health and disease conditions, including cancer. The human intestinal microbiome is thought to influence tumor development and progression in the gastrointestinal tract by various mechanisms. For example, Fusobacterium nucleatum, which primarily inhabits the oral cavity and causes periodontal disease, might contribute to aggressive tumor behavior through activation of chemokines such as CCL20 in esophageal cancer tissue. Composition of the intestinal microbiota is influenced by diet, lifestyle, antibiotics, and pro‐ and prebiotics. Therefore, by better understanding how the bacterial microbiota contributes to esophageal carcinogenesis, we might develop novel cancer prevention and treatment strategies through targeting the gastrointestinal microflora. This review discusses the current knowledge, available data and information on the relationship of microbiota with esophagitis, Barrett's esophagus, esophageal adenocarcinoma and squamous cell carcinoma.

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Section: Introductionmentioning

confidence: 99%

Review of the gut microbiome and esophageal cancer: Pathogenesis and potential clinical implications

Baba

Iwatsuki

Yoshida

et al. 2017

Annals of Gastroent Surgery

104

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show abstract

“…However, from the point of view that the human gut is the place for a mutualistic relationship between beneficial symbionts and commensals (1,2), antibiotics are no longer considered only beneficial, but also potentially harmful drug, as their overuse has been linked to microbiota impairment and related disorder (3).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Probiotics, Antibiotics, and Antipyretic Analgesics on Gut Microbiota Modification

Yun¹,

Kim²,

Kim³

et al. 2017

J Bacteriol Virol

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Human gut microbial community is playing a critical role in human health and associated with different human disease. In parallel, probiotics, antibiotics, and antipyretic analgesics (AAs) were developed to improve human health or cure human diseases. We therefore examined how probiotics, antibiotics, and AAs influence to the gut microbiota. Three independent case/control studies were designed from the cross-sectional cohort data of 1,463 healthy Koreans. The composition of the gut microbiota in each case and control group was determined via 16S ribosomal RNA Illumina next-generation sequencing. The correlation between microbial taxa and the consumption of each drug was tested using zero-inflated Gaussian mixture models, with covariate adjustment of age, sex, and body mass index (BMI). Probiotics, antibiotics, and AAs consumption yielded the significant differences in the gut microbiota, represented the lower abundance of Megasphaera in probiotics, the higher abundance of Fusobacteria in antibiotics, and the higher abundance of Butyrivibrio and Verrucomicrobia in AAs, compared to each control group. The reduction of Erysipelotrichaceae family was common in three drugs consumption.

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“…As a general rule, it was reported that antibiotic intake in mice increased adiposity [4,20,106,110,111], and thus favored the development of obesity and type II diabetes [71,102], besides affecting normal metabolic activity, hormonal and immune development. However, antibiotic treatment does not always display adverse effects on the GM of experimental animals.…”

Section: Specific Effects Of Antibiotics On the Human Gut Microbiotamentioning

confidence: 99%

“…Antibiotics are one of the most prescribed drugs in human medicine, particularly in pediatrics and neonatal nursing in developed countries [104,111]. The effect of these drugs on the human GM, both during and after the treatment has been widely investigated in recent years, although it is not yet fully understood [29].…”

Section: Specific Effects Of Antibiotics On the Human Gut Microbiotamentioning

confidence: 99%

“…However, in this stage of life, the GM is relatively strong and, in most instances, recovers after several weeks of ceasing the antibiotic treatment [29]. However, other studies have shown that after cessation of treatment, the microbiota requires several months to fully recover [29,111,113,124]. However, in some cases, it has even demonstrated that some bacterial groups eliminated by an antibiotic treatment not reappear again in several years after discontinuation of treatment [3,119,125].…”

Section: Specific Effects Of Antibiotics On the Human Gut Microbiotamentioning

confidence: 99%

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Food Additives and Contaminants: Effects on Human Gut Microbiota—A Review

Roca-Saavedra¹,

Mendez-Vilabrille²,

Miranda³

et al. 2016

Preprint

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Gut bacteria play an important role in several metabolic processes and human diseases, such as obesity and its co-morbidities, like fatty liver disease, insulin resistance/diabetes and cardiovascular events. Among several factors, dietary patterns, probiotics, prebiotics, synbiotics, antimicrobials and non-dietary factors, such as stress, age, exercise and climatic conditions, can dramatically impact the human gut microbiota diversity and equilibrium. However, the effect of minor food constituents, including food additives and trace contaminants, on human gut microbiota has received less attention. Consequently, the present review aimed to provide an objective perspective of the current knowledge regarding the impacts of minor food constituents on human gut microbiota and consequently, on human health.

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Antibiotics as deep modulators of gut microbiota: between good and evil

Cited by 534 publications

References 154 publications

Review of the gut microbiome and esophageal cancer: Pathogenesis and potential clinical implications

Review of the gut microbiome and esophageal cancer: Pathogenesis and potential clinical implications

The Effect of Probiotics, Antibiotics, and Antipyretic Analgesics on Gut Microbiota Modification

Food Additives and Contaminants: Effects on Human Gut Microbiota—A Review

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Antibiotics as deep modulators of gut microbiota: between good and evil

Cited by 534 publications

References 154 publications

Review of the gut microbiome and esophageal cancer: Pathogenesis and potential clinical implications

Review of the gut microbiome and esophageal cancer: Pathogenesis and potential clinical implications

The Effect of Probiotics, Antibiotics, and Antipyretic Analgesics on Gut Microbiota Modification

Food Additives and Contaminants: Effects on Human Gut Microbiota&mdash;A Review

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Food Additives and Contaminants: Effects on Human Gut Microbiota—A Review