Antibiotics change contractility of guinea pig aorta and trachea to histamine after a short exposure to LPS

Antibiotic prophylaxis influences cardiovascular stability in complicated surgery

“…However, the underlying mechanisms of these antibiotic effects are as yet unknown. The agents used in this study have been shown to interact with signal transduction pathways [14] and comparable complex effects have been demonstrated for chinolones [41,42] as well Table 1. Median and range systolic blood pressure (BPsys), diastolic blood pressure (BPdias), heart rate (HR) and plasma histamine (HIA) at 5 of the 10 scheduled registration points in the three groups tested (orientation for the 5 additional points see Fig.…”

“…Antibiotics are now known to have complex interactions with the immune system [11,12], including LPS release [13] and modulation of signal transduction pathways in contractile elements [14]. However, adverse drug reactions, associated with significant mortality and morbidity have resulted in the withdrawal of several active antibiotics, including new fluoroquilolones [15,16].…”