Antibiotics for syphilis diagnosed during pregnancy

Walker, Gordon J.

doi:10.1002/14651858.cd001143

Cited by 75 publications

(71 citation statements)

References 131 publications

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“…50 Screening and treatment for syphilis is an essential component of all antenatal programmes in endemic countries. Although a Cochrane review of antibiotic treatment of syphilis in pregnancy did not identify any eligible studies, 51 randomised trials of screening and treatment for syphilis would be unethical, so appropriate observational studies should be used to establish the eff ectiveness of treatment. Findings of a random-eff ect meta-analysis of eight observational studies, [52][53][54][55][56][57][58][59] six from low-income and middle-income countries, showed a signifi cant 80% reduction in stillbirths in infected women receiving treatment compared with those receiving no treatment (table 1).…”

Section: Comprehensive Emergency Obstetric Carementioning

confidence: 99%

Stillbirths: what difference can we make and at what cost?

Bhutta¹,

Yakoob²,

Lawn³

et al. 2011

The Lancet

265

171

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Section: Comprehensive Emergency Obstetric Carementioning

confidence: 99%

Stillbirths: what difference can we make and at what cost?

Bhutta¹,

Yakoob²,

Lawn³

et al. 2011

The Lancet

265

171

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“…It is a complex systemic disease with protean manifestations and virtually any organ in the body can be involved. Syphilis in a pregnant woman results in miscarriage, stillbirth, or a congenitally infected baby (1). The risk of vertical transmission reduces as maternal syphilis advances to late stages, but in early latent stage which is mostly asymptomatic the risk of vertical transmission remains about 30% to 60% (2).…”

Section: Introductionmentioning

confidence: 99%

Syphilis among pregnant women in Juba, Souther Sudan

Sserunjogi

Lado²,

Amwayi³

et al. 2011

E Af Med Jrnl

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Conclusions: This is the first study to determine the prevalence and associated factors in the three clinics in Juba, South Sudan. There is a high prevalence of syphilis in pregnant women attending the selected health facilities. Treponema Pallindum Haemagglulination Assay can be used as a field test for syphilis due to its high sensitivity and specificity. Health education, screening and treating positive expectant mothers can reduce the prevalence of syphilis.

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“…Some studies even recommend a second dose for pregnant women with early syphilis. [11][12][13][14] Treatment should be followed with a sonogram examination of fetus. Ultrasonogram should always be done before treatment so as to assess the outcome, as sonographic evidence of congenital syphilis is a sign of treatment failure.…”

Section: 7%mentioning

confidence: 99%

Retrospective analysis of burden of maternal syphilis and the outcome in the fetus in a tertiary care centre

et al. 2018

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Background: Syphilis in pregnancy has its own significance with regards to the outcome of pregnancy. In the meanwhile, it also reflects the effectiveness of health system in the community.Methods: A retrospective study was carried out in a tertiary care centre in Chennai between January 2014 and July 2015 to determine the seroprevalence of syphilis in pregnant women. A total of 4423 ANC mother attending the hospital were included in the study.Results: Of the 4423 cases studied, 7 cases were found to be positive for RPR accounting to the prevalence of 0.15%. One mother was symptomatic, presenting with condyloma lata. TPHA was positive in 2 cases (28.5%) Most common association was with HIV infection, 2/7 (28.5%). All the RPR positive patients were treated with tablet erythromycin 500 mg qid × 14 days. Epidose for the partner was given. The outcome was uneventful except for one. A single case of congenital syphilis was reported.Conclusions: Though the prevalence of RPR positive in routine screening is less, the outcome of single congenital syphilis is worrisome. To conclude, although the prevalence of syphilis (0.1%) is low, routine screening of asymptomatic ante natal women is recommended to reduce the incidence of congenital syphilis & perinatal complications and it is always better to treat the ANC mothers with syphilis with Penicillin, preferably with a second dose also.

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Antibiotics for syphilis diagnosed during pregnancy

Cited by 75 publications

References 131 publications

Stillbirths: what difference can we make and at what cost?

Stillbirths: what difference can we make and at what cost?

Syphilis among pregnant women in Juba, Souther Sudan

Retrospective analysis of burden of maternal syphilis and the outcome in the fetus in a tertiary care centre

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