Antibiotics for treating infected burn wounds

Lu, Jing; Yang, Ming; Zhan, Ming; Xu, Xuewen; Yue, Jirong; Xu, Ting

doi:10.1002/14651858.cd012084

Cited by 7 publications

(2 citation statements)

References 22 publications

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“…Therapeutic approaches in patients with severe burns requires use of antibacterial drugs [18][19][20]. Opportunistic microorganisms such as S. aureus, which are the leading causative agents of opportunistic infections, are an important problem nowadays as these microorganisms developed resistance to methicillin [21] and some other antibiotics such as aminoglycosides and tetracyclines due to their uncontrolled used in medicine [1,2,4,12,13].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Parameters of the Susceptibility of Staphylococcus Spp. To Aminoglycosides and Doxycycline

et al. 2020

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The aim: To perform microbiological investigation and analytic mathematic prediction of clinical isolates of S. aureus to aminoglycosides in patients with severe burns. Materials and methods: We analyzed resistance of 199 S. aureus strains to aminoglycosides (gentamicin, tobramycin and amikacin) and doxycycline from 435 patients treated in the regional hospital due to burns for the period from 2011-2017. Results: We created predictive curves for the prediction of susceptibility of S. aureus strains to aminoglycosides and doxycycline based on the changes in S. aureus resistance during the years of observation and expressed in mathematic equations. Susceptibility of S. aureus to gentamicin was 42.86 % at the end of observation and will decline in future. Despite tobramycin was efficient against 72.86 % of strains in 2017, mathematic modeling indicates rapid decline in its efficacy in future. Efficacy of amikacin was dropping during the last years, but according to the equation it efficacy will increase over 60 % in 2018. S. aureus susceptibility to doxycycline was 65.38 % in 2017 and mathematic modeling indicates its gradual decline in the nearest future. Conclusions: Predicitive values of S. aureus susceptibility indicates not sufficient efficacy of these drugs in patients with infectious complications of burns. Tendency of the slight decline of S. aureus susceptibility to doxycycline still indicates sufficient levels of its efficacy in the nearest future. This justify its use as a second-line therapy with the causative agent in patients with burns.

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Section: Discussionmentioning

confidence: 99%

Prognostic Parameters of the Susceptibility of Staphylococcus Spp. To Aminoglycosides and Doxycycline

et al. 2020

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“…Additionally, chronic wounds, burns, and diabetic ulcers have extended healing times. As an example, a high level of exudates is found in burn wounds, and this provides a favorable environment for bacterial growth [35]. The presence of these bacteria leads to wound inflammation through the expression of proinflammatory cytokines [36].…”

Section: Pathophysiology and Healing Process Of The Woundmentioning

confidence: 99%

Recent Advances on Bacterial Cellulose-Based Wound Management: Promises and Challenges

Moradpoor

Mohammadi

Safaei

et al. 2022

International Journal of Polymer Science

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Wound healing is a therapeutic challenge due to the complexity of the wound. Various wounds could cause severe physiological trauma and bring social and economic burdens to the patient. The conventional wound healing treatments using bandages and gauze are limited particularly due to their susceptibility to infection. Different types of wound dressing have developed in different physical forms such as sponges, hydrocolloids, films, membranes, and hydrogels. Each of these formulations possesses distinct characteristics making them appropriate for the treatment of a specific wound. In this review, the pathology and microbiology of wounds are introduced. Then, the most recent progress on bacterial cellulose- (BC-) based wound dressing discussed and highlighted their antibacterial and reepithelization properties in vitro and in vivo wound closure. Finally, the challenges and future perspectives on the development of BC-based wound dressing biomaterials are outlined.

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