Antibiotics in Drinking Water in Shanghai and Their Contribution to Antibiotic Exposure of School Children

Wang, Hexing; Wang, Na; Wang, Bin; Zhao, Qi; Fang, Hong; Fu, Chaowei; Tang, Chuanxi; Jiang, Feng; Zhou, Ying; Chen, Yue; Jiang, Qingwu

doi:10.1021/acs.est.5b05749

Cited by 237 publications

(69 citation statements)

References 39 publications

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“…In another drinking water source in Shanghai, 11 ARGs were detected with high concentrations, and sul II was present at the highest concentration (4.19 × 10 8 copies/L). This phenomenon might reflect the widespread use of sulfonamides in this region [19]. Furthermore, ARGs could be transferred between bacteria through transposons, plasmids and integrons [44].…”

Section: Discussionmentioning

confidence: 98%

Occurrence, Seasonal Variation and Risk Assessment of Antibiotics in Qingcaosha Reservoir

Jiang

et al. 2018

Water

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Qingcaosha Reservoir is an important drinking water source in Shanghai. The occurrence of five groups of antibiotics was investigated in the surface water of this reservoir over a one-year period. Seventeen antibiotics were selected in this study based on their significant usage in China. Of these antibiotics, 16 were detected, while oxytetracycline was not detected in any sampling site. The detected frequency of tylosin was only 47.92% while the other 15 antibiotics were above 81.25%. The dominant antibiotic was different in four seasons: norfloxacin was dominant in spring, and penicillinV was dominant in summer, autumn and winter, with medium concentrations of 124.10 ng/L, 89.91 ng/L, 180.28 ng/L, and 216.43 ng/L, respectively. The concentrations and detection frequencies of antibiotics were notably higher in winter than in other seasons, demonstrating that low temperature and low flow may result in the persistence of antibiotics in the aquatic environment. Risk assessment suggested that norfloxacin, ciprofloxacin, penicillinV, and doxycycline in the surface water presented high ecological risks.

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Section: Discussionmentioning

confidence: 98%

Occurrence, Seasonal Variation and Risk Assessment of Antibiotics in Qingcaosha Reservoir

Jiang

et al. 2018

Water

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“…Several epidemiological studies have reported that antibiotic use in children was positively associated with obesity in children[19–22]. Recently, several studies have reported extensive exposure of school-aged children to antibiotics by measuring antibiotics in urine, and certain antibiotics, such as florfenicol and trimethoprim, were related to obesity [23,24]. …”

Section: Introductionmentioning

confidence: 99%

Effects of oral florfenicol and azithromycin on gut microbiota and adipogenesis in mice

Wang

Shi

et al. 2017

PLoS ONE

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Certain antibiotics detected in urine are associated with childhood obesity. In the current experimental study, we investigated two representative antibiotics detected in urine, florfenicol and azithromycin, for their early effects on adipogenesis, gut microbiota, short-chain fatty acids (SCFAs), and bile acids in mice. Thirty C57BL/6 mice aged four weeks were randomly divided into three groups (florfenicol, azithromycin and control). The two experimental groups were administered florfenicol or azithromycin at 5 mg/kg/day for four weeks. Body weight was measured weekly. The composition of the gut microbiota, body fat, SCFAs, and bile acids in colon contents were measured at the end of the experiment. The composition of the gut microbiota was determined by sequencing the bacterial 16S rRNA gene. The concentration of SCFAs and bile acids was determined using gas chromatography and liquid chromatography coupled to tandem mass spectrometry, respectively. The composition of the gut microbiota indicated that the two antibiotics altered the gut microbiota composition and decreased its richness and diversity. At the phylum level, the ratio of Firmicutes/Bacteroidetes increased significantly in the antibiotic groups. At the genus level, there were declines in Christensenella, Gordonibacter and Anaerotruncus in the florfenicol group, in Lactobacillus in the azithromycin group, and in Alistipes, Desulfovibrio, Parasutterella and Rikenella in both the antibiotic groups. The decrease in Rikenella in the azithromycin group was particularly noticeable. The concentration of SCFAs and secondary bile acids decreased in the colon, but the concentration of primary bile acids increased. These findings indicated that florfenicol and azithromycin increased adipogenesis and altered gut microbiota composition, SCFA production, and bile acid metabolism, suggesting that exposure to antibiotics might be one risk factor for childhood obesity. More studies are needed to investigate the specific mechanisms.

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“…The security of tap water is always concerned in the world, especially in developing country. Currently, the antibiotics are not considered as one kind of organic contaminant in tap water, but some of them have been detected because the present conventional wastewater treatment plants cannot completely remove the antibiotics . In this study, the recovery of LVSS was investigated in real sample.…”

Section: Resultsmentioning

confidence: 99%

Large volume sample stacking of cationic tetracycline antibiotics toward 10 ppb level analysis by capillary electrophoresis with UV detection

Huang

et al. 2016

Electrophoresis

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This paper aimed to build up a sensitive CE method for the analysis of tetracyclines (TCs) antibiotics (including tetracycline, chlorotetracycline, oxytetracycline, and doxycycline) with conventional UV detection. Here, the large volume sample stacking was applied to achieve in capillary preconcentration of the targets. To achieve large volume sample stacking, the essential step was a large volume of sample (around 83.3% of total capillary length from inlet to detection window) hydrodynamically loaded. Then, the reserved voltage was added in order to push the sample matrix out of the capillary. Due to different pH between sample solution (pH 4.6) and BGE (pH 11.0), the cationic TCs would turn into negatively charged while the sample matrix was removing from the capillary. Finally, the anionic TCs were stacked at the inlet for the subsequent separation. Although the loss of sample existed during their charge transformation, the LODs could be improved around 40 times than that obtained by normal hydrodynamic injection CE method. Here, the LODs were in the range of 8.1-14.5 μg/L, around 10 ppb that close to the level by electrochemiluminescence or laser-induced fluorescence detection of TCs by CE. The precision was characterized by RSDs of migration times and peak areas, which were in the range of 0.19-0.24% and 0.97-2.54%, respectively. The recoveries of the developed method were in the range of 95-112% by spiking TCs in the tap water. The proposed inline preconcentration CE method could be a simple, speed, and sensitive method for the quantitative analysis of TCs.

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Antibiotics in Drinking Water in Shanghai and Their Contribution to Antibiotic Exposure of School Children

Cited by 237 publications

References 39 publications

Occurrence, Seasonal Variation and Risk Assessment of Antibiotics in Qingcaosha Reservoir

Occurrence, Seasonal Variation and Risk Assessment of Antibiotics in Qingcaosha Reservoir

Effects of oral florfenicol and azithromycin on gut microbiota and adipogenesis in mice

Large volume sample stacking of cationic tetracycline antibiotics toward 10 ppb level analysis by capillary electrophoresis with UV detection

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