Antibiotics in frozen bone grafts can cause allergic reactions in recipient patients

Crnogaća, Krešimir; Bićanić, Goran; Delimar, Domagoj

doi:10.1016/j.mehy.2014.12.008

Cited by 4 publications

(5 citation statements)

References 23 publications

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“…The Lobator Marburg device, consisting of an electronic heating unit and the sterile disinfection set box, validated by the German Federal Institute for Drugs and Medical Devices, is used since 1993, for the thermal disinfection of the femoral heads [17]. This compact system has been demonstrated to inactivate HIV 1, HIV 2, HTLV, CMV, Hepatitis B and C as well as Treponema Pallidum and vegetative bacteria, increasing the safety of the allogenic bone graft while maintaining its biomechanical and biological valences (18,19,20).…”

Section: Resultsmentioning

confidence: 99%

Configuration and Management of a Femoral Heads Bone Bank in a Specialised Tertiary Orthopaedic Hospital in Bucharest

Stoica¹,

Munteanu²,

Luchian³

et al. 2020

Rev. Chim.

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The purpose of the current paper is to describe the functioning protocol of a femoral heads bone bank in a specialised tertiary orthopaedic hospital in Bucharest and the results of its activity between January 2011 and December 2016. Since the initiation of the femoral head bone bank in 2011, we selected and tested 761 donors of femoral heads. Out of them, we implanted 435 grafts to a total of 242 recipient patients. We performed a thorough donor screening process, which resulted in a significant proportion of femoral head allografts discarded, mainly due to a positive hepatitis B or/and C viruses test or a positive result of the bacterial culture from the bone graft (in 3% of the grafts); the offending micro-organism was a Methicillin-Sensible Staphylococcus spp. Our bone bank may serve as a framework for developing similar structures by other hospitals in our country or elsewhere.

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Section: Resultsmentioning

confidence: 99%

Configuration and Management of a Femoral Heads Bone Bank in a Specialised Tertiary Orthopaedic Hospital in Bucharest

Stoica¹,

Munteanu²,

Luchian³

et al. 2020

Rev. Chim.

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“…ABs are predominately used to treat different diseases; however, these compounds are used also for nonmedical purposes as feed proficiency enhancers and growth promoters [3]. The misuse of these compounds can lead to the presence of their residues in animal derived foods and can cause undesirable effects such as allergic reactions [4], development of bacterial resistance against common human infections [5], and liver damage [6]. Because of this fact that large parts of ABs are used for animals, the presence of AB residues is not far mind in animal derived foods [7] and they must be controlled.…”

Section: Introductionmentioning

confidence: 99%

Preparation of multiwall carbon nanotube/urea‐formaldehyde nanocomposite as a new sorbent in solid‐phase extraction and its combination with deep eutectic solvent‐based dispersive liquid–liquid microextraction for extraction of antibiotic residues in honey

Shahi

Javadi

Mogaddam

et al. 2020

J of Separation Science

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A solid‐phase extraction method combined with deep eutectic solvent‐based dispersive liquid–liquid microextraction has been developed for the extraction of three antibiotics in honey samples prior to their determination by ion mobility spectrometry. In this method, first, a multiwall carbon nanotube/urea‐formaldehyde nanocomposite was synthesized using co‐precipitation polymerization method and then it was used as a sorbent for the analytes extraction from the samples. After that the adsorbed analytes were eluted from the sorbent using a water‐miscible organic solvent. The collected elution solvent was mixed with tetrabutylammonium chloride:butanol deep eutectic solvent and the mixture was applied in the following microextraction method. The method provided low limits of detection and quantification in the ranges of 0.32–0.86 and 1.1–2.9 ng/g, respectively. The method had a proper repeatability expressed as relative standard deviation less than or equal to 9.1%. The validated method was successfully performed on different honey samples obtained from different producers.

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“…[5][6][7][8] However, these adjuncts have been associated with potentially undesirable side effects, including cellulitis, periprosthetic fracture and poor wound healing. 9,10…”

Section: Introductionmentioning

confidence: 99%

“…5–8 However, these adjuncts have been associated with potentially undesirable side effects, including cellulitis, periprosthetic fracture and poor wound healing. 9,10 This has led to the development of other antibiotic delivery devices, such as calcium sulphate beads (CSBs), to help mitigate the risk of infection in revision surgeries.…”

Section: Introductionmentioning

confidence: 99%

Utilisation of calcium sulphate beads in one-stage aseptic revision total hip arthroplasty

et al. 2020

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Introduction: Periprosthetic joint infection (PJI) affects many revision total hip arthroplasty (THA) patients, contributing to a concomitant rise in revision costs. Means of decreasing the risk of PJI include the use of antibiotic adjuncts, such as calcium sulphate beads (CSBs). Mixed with antibiotics, the potential benefits of CSBs include dissolvability and antibiotic drug elution. However, information comparing them in aseptic revision is scarce. Therefore, this study investigated CSB utilisation for infection prevention in aseptic revision THA. Specifically, we compared (1) infection rates; (2) lengths of stay; (3) subsequent infection procedures; and (4) final surgical outcome in 1-stage aseptic revision THA patients who did received CSBs to 1-stage aseptic revision THA patients who did not. Methods: A retrospective chart review was performed to identify all patients who underwent an aseptic revision THA between January 2013 and December 2017. Patients who received CSBs ( n = 48) were compared to non-CSB patients ( n = 58) on the following outcomes: postoperative infections, lengths of stay (LOS), subsequent irrigation and debridements (I+Ds), and final surgical outcome, classified as successful THA reimplantation, retained antibiotic spacer, or Girdlestone procedure. Chi-square and t-testing were used to analyse the variables. Results: There was no significant differences found between CSB patients and non-CSB patients in postoperative infections ( p = 0.082), LOS ( p = 0.179), I+Ds ( p = 0.068), and final surgical outcome ( p = 0.211). Conclusion: This study did not find any statistical difference between CSBs and standard of care in infection rates and surgical outcomes. The advantage of these beads for 1-stage aseptic revisions is questionable.

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Antibiotics in frozen bone grafts can cause allergic reactions in recipient patients

Cited by 4 publications

References 23 publications

Configuration and Management of a Femoral Heads Bone Bank in a Specialised Tertiary Orthopaedic Hospital in Bucharest

Configuration and Management of a Femoral Heads Bone Bank in a Specialised Tertiary Orthopaedic Hospital in Bucharest

Preparation of multiwall carbon nanotube/urea‐formaldehyde nanocomposite as a new sorbent in solid‐phase extraction and its combination with deep eutectic solvent‐based dispersive liquid–liquid microextraction for extraction of antibiotic residues in honey

Utilisation of calcium sulphate beads in one-stage aseptic revision total hip arthroplasty

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