Antibiotics in the Control of Plant Diseases

Zaumeyer, W. J.

doi:10.1146/annurev.mi.12.100158.002215

Cited by 20 publications

(10 citation statements)

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“…Bacterial plant diseases represent a major limitation to crop production and contribute to significant economic losses annually. Copper compounds and antibiotics have been successfully employed as management strategies in fields since the early 1900s (Elguindi et al, 2011;Zaumeyer, 1958). However, the use of chemical bactericides as crop protectants represents a threat to the environment and may result in a risk for public health because of the rapid emergence of resistance that could eventually be acquired by clinical pathogens (Sundin et al, 2016).…”

Section: Discussion An Effective Screening Methodology To Identify T3...mentioning

confidence: 99%

“…tomato. Antibiotics and copper-based compounds have traditionally been used (Zaumeyer, 1958); however, their application is now restricted in many countries (Duffy et al, 2005;Mackie et al, 2012) because of their environmental impact. An important emerging strategy to combat pathogens seeks to block the ability of bacteria to harm the host by inhibiting bacterial virulence factors (Rasko and Sperandio, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Type III secretion inhibitors for the management of bacterial plant diseases

Puigvert

Solé

López-Garcı́a

et al. 2018

Molecular Plant Pathology

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The identification of chemical compounds that prevent and combat bacterial diseases is fundamental for crop production. Bacterial virulence inhibitors are a promising alternative to classical control treatments, because they have a low environmental impact and are less likely to generate bacterial resistance. The major virulence determinant of most animal and plant bacterial pathogens is the type III secretion system (T3SS). In this work, we screened nine plant extracts and 12 isolated compounds-including molecules effective against human pathogens-for their capacity to inhibit the T3SS of plant pathogens and for their applicability as virulence inhibitors for crop protection. The screen was performed using a luminescent reporter system developed in the model pathogenic bacterium Ralstonia solanacearum. Five synthetic molecules, one natural product and two plant extracts were found to down-regulate T3SS transcription, most through the inhibition of the regulator hrpB. In addition, for three of the molecules, corresponding to salicylidene acylhydrazide derivatives, the inhibitory effect caused a dramatic decrease in the secretion capacity, which was translated into impaired plant responses. These candidate virulence inhibitors were then tested for their ability to protect plants. We demonstrated that salicylidene acylhydrazides can limit R. solanacearum multiplication in planta and protect tomato plants from bacterial speck caused by Pseudomonas syringae pv. tomato. Our work validates the efficiency of transcription reporters to discover compounds or natural product extracts that can be potentially applied to prevent bacterial plant diseases.

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Section: Discussion An Effective Screening Methodology To Identify T3...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Type III secretion inhibitors for the management of bacterial plant diseases

Puigvert

Solé

López-Garcı́a

et al. 2018

Molecular Plant Pathology

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“…Initial forays into the chemical management of bacterial diseases focused on a ‘kitchen sink’ approach, involving the testing of a wide range of available compounds against a wide range of diseases (e.g. Zaumeyer, ). From these types of study, copper compounds (introduced in the 1880s) and the antibiotic streptomycin (1950s) proved to be the most efficacious, and have been the most commonly used bactericide spray treatments for bacterial disease management on plants, mainly targeting Pseudomonas spp., Xanthomonas spp.…”

Section: Management Of Bacterial Diseases With Copper and Antibioticsmentioning

confidence: 99%

Bacterial disease management: challenges, experience, innovation and future prospects

Sundin

Castiblanco

Yuan

et al. 2016

Molecular Plant Pathology

206

142

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Plant diseases caused by bacterial pathogens place major constraints on crop production and cause significant annual losses on a global scale. The attainment of consistent effective management of these diseases can be extremely difficult, and management potential is often affected by grower reliance on highly disease-susceptible cultivars because of consumer preferences, and by environmental conditions favouring pathogen development. New and emerging bacterial disease problems (e.g. zebra chip of potato) and established problems in new geographical regions (e.g. bacterial canker of kiwifruit in New Zealand) grab the headlines, but the list of bacterial disease problems with few effective management options is long. The ever-increasing global human population requires the continued stable production of a safe food supply with greater yields because of the shrinking areas of arable land. One major facet in the maintenance of the sustainability of crop production systems with predictable yields involves the identification and deployment of sustainable disease management solutions for bacterial diseases. In addition, the identification of novel management tactics has also come to the fore because of the increasing evolution of resistance to existing bactericides. A number of central research foci, involving basic research to identify critical pathogen targets for control, novel methodologies and methods of delivery, are emerging that will provide a strong basis for bacterial disease management into the future. Near-term solutions are desperately needed. Are there replacement materials for existing bactericides that can provide effective disease management under field conditions? Experience should inform the future. With prior knowledge of bactericide resistance issues evolving in pathogens, how will this affect the deployment of newer compounds and biological controls? Knowledge is critical. A comprehensive understanding of bacterial pathosystems is required to not only identify optimal targets in the pathogens, but also optimal seasonal timings for deployment. Host resistance to effectors must be exploited, carefully and correctly. Are there other candidate genes that could be targeted in transgenic approaches? How can new technologies (CRISPR, TALEN, etc.) be most effectively used to add sustainable disease resistance to existing commercially desirable plant cultivars? We need an insider's perspective on the management of systemic pathogens. In addition to host resistance or reduced sensitivity, are there other methods that can be used to target these pathogen groups? Biological systems are variable. Can biological control strategies be improved for bacterial disease management and be made more predictable in function? The answers to the research foci outlined above are not all available, as will become apparent in this article, but we are heading in the right direction. In this article, we summarize the contributions from past experiences in bacterial disease management, and also describe how advances in bacterial...

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“…"Curling factor" was an appropriate name to apply to this antibiotic, which manifests its' inhibition of certain fungi by the curling and dis,tortion of hyphae. Griseofulvin is active against a number of fungi pathogenic to plants, and its use in the control of plant mycoses has been noted in the review by Zaumeyer (1958).…”

Section: B W Manktelowtmentioning

confidence: 99%

Thein vitroactivity of griseofulvin on some dermatophytes of veterinary interest

Manktelow¹

1960

New Zealand Veterinary Journal

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Antibiotics in the Control of Plant Diseases

Cited by 20 publications

References 0 publications

Type III secretion inhibitors for the management of bacterial plant diseases

Type III secretion inhibitors for the management of bacterial plant diseases

Bacterial disease management: challenges, experience, innovation and future prospects

Thein vitroactivity of griseofulvin on some dermatophytes of veterinary interest

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