Antibiotics in the Practice of Periodontics

Antibiotics in the Treatment of Human Periodontal Diseases

“…the concentration of that antimicrobial agent which can be achieved in blood with optimal therapy.26 Table 1 shows the peak serum concentrations and breakpoints for several commonly used antibiotics. Since antibiotics may be at different concentrations in the gingival fluids which bathe the subgingival microflora, the "gingival fluid breakpoint," or the concentration of the antibiotic Chloramphenicol (oral) [3][4][5][6][7][8][9][10][11][12] Clindamycin (oral) 26-32. t Serum "breakpoint" defined as the concentration of antibiotic in the blood that can be achieved with optimal therapy. Gingival fluid "breakpoints" have been determined to date for tetracycline31 and minocycline.32 in gingival fluid when given systemically, is of importance in evaluating the antimicrobial sensitivity of periodontal pathogens.…”

“…In phase contrast or dark field examination of the flora from these lesions, 30-50% are often found to be motile rods and spirochetes. (4) The deep pocket microflora in localized forms ofjuvenile Periodontitis is also mainly comprised of gram-negative organisms (about 65%). Evidence from studies of Newman and Socransky10 show that a significant number of the isolates from the juvenile Periodontitis pockets are Capnocytophaga.…”

Effect of controlled-release PeriochipTM on clinical and microbiological parameters in patients of chronic periodontitis

“…This increases the chances of development of resistance, alteration of commensal flora, and increased potential for adverse effects. [1314151617] Local administrations, therefore, provide a useful answer to these problems and are developed to deliver therapeutic levels of antibacterial agents directly into the pocket with no systemic side effects; however, the important factor in the success of this treatment is the ability to control and to prolong the release rate of the therapeutic agent from the device. [2]…”

Assessment of Morbidity After Periodontal Resective Surgery

“…Resective periodontal surgery 1‐7 is a common procedure for periodontal debridement and resolution of osseous defects caused by periodontal disease. Periodontal surgical procedures by their nature are associated with a risk of developing postoperative complications, including infection and pain, which are a matter of concern to the practitioner and the patient.…”