2023
DOI: 10.1101/2023.03.25.533086
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Antibiotics promote intestinal growth of carbapenem-resistantEnterobacteriaceaeby enriching nutrients and depleting microbial metabolites

Abstract: The intestine is the primary colonisation site for carbapenem-resistant Enterobacteriaceae (CRE) and serves as a reservoir of CRE that cause invasive infections (e.g. bloodstream infections). Antibiotics disrupt colonisation resistance mediated by the gut microbiota, promoting the expansion of CRE within the intestine. We used ex vivo faecal cultures to measure the impact of antibiotics (that promote CRE intestinal colonisation) on the faecal microbiota from healthy human donors. We demonstrated that antibioti… Show more

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Cited by 1 publication
(4 citation statements)
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“…Broad-spectrum antibiotics cause significant decreases in the abundance and diversity of a wide range of gut commensals, thus reducing competition for nutrients [6,78]. These nutrient-defined intestinal niches can then be exploited by pathogens, such as C. difficile, CRE and S. Typhimurium [37,38,57,79,80].…”
Section: Pathogen Exploitation Of the Altered Nutrient Environment Fo...mentioning
confidence: 99%
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“…Broad-spectrum antibiotics cause significant decreases in the abundance and diversity of a wide range of gut commensals, thus reducing competition for nutrients [6,78]. These nutrient-defined intestinal niches can then be exploited by pathogens, such as C. difficile, CRE and S. Typhimurium [37,38,57,79,80].…”
Section: Pathogen Exploitation Of the Altered Nutrient Environment Fo...mentioning
confidence: 99%
“…It is also important to consider that there may be differences in the preferences that bacteria have for particular available nutrients, which will impact the development of microbiome therapeutics. Different species of Enterobacteriaceae have different nutrient utilization profiles in aerobic and anaerobic environments and also have a different order of nutrient preference [79, 128]. These results suggest that microbiome therapeutics should include multiple gut commensals that are able to outcompete pathogens for all available nutrients that could support pathogen growth to fully occupy all available nutrient niches in the gut and effectively restore colonization resistance.…”
Section: Introductionmentioning
confidence: 99%
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