Antibiotics Residues of Some Famous Antibiotics in Raw Milk of Different Species Sold at Local Markets

Makarem, Hussein; Leboudy, Ahlam; Mahmoud, E. Abd El-Moneim

doi:10.5455/ajvs.91952

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…In comparison with other data concerning antibiotic residue in milk, the oxytetracycline concentration reported in our study was higher than that reported in Turkey (29.36 μg/kg) [ 62 ] and North Italy (5.82 μg/kg) [ 63 ]. On the other hand, it was less than that of Ardabil, Iran (40.0 μg/kg) [ 64 ]; Egypt (97.9 μg/kg in cow’s milk and 85.5 μg/kg in Buffalo’s milk) [ 65 ]; Bangladesh (61.29 μg/kg) [ 36 ]; Ethiopia (45–192 µg/kg) [ 66 ]; India (70.7 μg/kg) [ 67 ]; and the United States (34.21 μg/kg) [ 68 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Antibiotic Resistance of Staphylococcus aureus and Escherichia coli Isolated from Bovine Raw Milk in Lebanon: A study on Antibiotic Usage, Antibiotic Residues, and Assessment of Human Health Risk Using the One Health Approach

et al. 2022

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The emergence, persistence, and spread of antibiotic-resistant microbes is a tremendous public health threat that is considered nowadays a critical One Health issue. In Lebanon, the consumption of raw bovine milk has been recently reported as a result of the financial crisis. The objectives of the current study were (1) to evaluate raw bovine milk samples in a comprehensive manner for the types of antibiotics used and their residues, (2) to determine the presence of mesophilic bacteria, extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and methicillin-resistant Staphylococcus aureus (MRSA), and (3) to determine the associated human health risk caused by drinking raw milk with antibiotic residues among all age categories. LC-MS-MS was used to carry out the analysis. From 200 milk samples, 30 (15%) were found contaminated with four major antibiotics. The highest average concentration detected was for oxytetracyline 31.51 ± 13.23 μg/kg, followed by 5.5 ± 0.55 μg/kg for gentamicin, 4.56 ± 0.73 μg/kg for colistin, and 4.44 ± 0.89 μg/kg for tylosin. The mean contamination among most samples was below the maximum residue limits (MRLs). Upon comparison with the acceptable daily intake (ADI), the estimated daily intake (EDI) across all age groups was acceptable. The hazard quotient (HQ) was also below 1 across all age groups, signifying the absence of associated health risks for the Lebanese consumers. On the other hand, all milk samples were found exceeding the maximum tolerable value of mesophilic flora. Antibiotic-resistant bacteria (ARB) were detected and represented by ESBL-producing E. coli and MRSA isolates. Thus, the greatest threat of antibiotic use in Lebanon does not fall under antibiotic residues but rather the proliferation of antibiotic resistance in potentially pathogenic bacteria. In this study, the virulence profile of detected bacteria was not investigated; thus their pathogenicity remains unknown. Therefore, to mitigate this health threat in Lebanon, a “One Health” action plan against ABR is required. It will provide a framework for continued, more extensive action to reduce the emergence and spread of ABR in Lebanon.

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Section: Discussionmentioning

confidence: 99%

Prevalence and Antibiotic Resistance of Staphylococcus aureus and Escherichia coli Isolated from Bovine Raw Milk in Lebanon: A study on Antibiotic Usage, Antibiotic Residues, and Assessment of Human Health Risk Using the One Health Approach

et al. 2022

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“…Additionally, failure to follow the instructions of antibiotics manufacturers also accounts for residues occurrence in milk (Bacanlı & Başaran, 2019;FSA, 2015). The withdrawal period can be defined as the time that must elapse between the last administration of a veterinary medicine and the slaughter or production of food from that animal, to ensure that the food does not contain levels of the medicine that exceed the maximum residue limit (Anika et al, 2019;El-Makarem et al, 2020). Indeed, the presence of residues at limits exceeding the acceptable range is considered illegal (Sachi et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Detecting Antibiotic Residues Among Sheep Milk using YCT, DDA, and Acidification Method in Erbil city, Kurdistan Region, Iraq

Almashhadany¹

2020

BUASVMCN-ASB

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Presence of antibiotic residues in milk is increasingly recognized as a global health issue owing to associated health risks and emergence of antibiotic resistant bacteria. The aim of this study was to determine the prevalence of antibiotic residues in sheep raw milk sold in Erbil governorate. The screening tests performed were; yoghurt culture, acidification, and disc diffusion tests. Randomly selected farms and sale points within the city were sampled. Out of 450 collected samples, 15.8% and 14.4% of them contained antibiotic residues according to yoghurt culture and disc diffusion tests, respectively. However, acidification test showed insignificant (P = 0.384) slightly higher prevalence (17.3%). Minor association was found between increase of residue prevalence and progress of summer-autumn months. Raising awareness among farmers and sale workers regarding withdrawal periods and risks of antibiotic residues are highly recommended to mitigate the health issues associated with consumption of contaminated milk.

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Application of solidified floating organic droplet dispersive liquid–liquid microextraction for determination of veterinary antibiotic residues in milk samples with greenness assessment

Mohamed,

ELbalkiny

2023

Microchemical Journal

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Antibiotics Residues of Some Famous Antibiotics in Raw Milk of Different Species Sold at Local Markets

Cited by 4 publications

References 13 publications

Prevalence and Antibiotic Resistance of Staphylococcus aureus and Escherichia coli Isolated from Bovine Raw Milk in Lebanon: A study on Antibiotic Usage, Antibiotic Residues, and Assessment of Human Health Risk Using the One Health Approach

Prevalence and Antibiotic Resistance of Staphylococcus aureus and Escherichia coli Isolated from Bovine Raw Milk in Lebanon: A study on Antibiotic Usage, Antibiotic Residues, and Assessment of Human Health Risk Using the One Health Approach

Detecting Antibiotic Residues Among Sheep Milk using YCT, DDA, and Acidification Method in Erbil city, Kurdistan Region, Iraq

Application of solidified floating organic droplet dispersive liquid–liquid microextraction for determination of veterinary antibiotic residues in milk samples with greenness assessment

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