Antibiotics versus placebo for acute bacterial conjunctivitis

Sheikh, Aziz; Hurwitz, Brian; Schayck, C.P. van; McLean, Susannah; Nurmatov, Ulugbek

doi:10.1002/14651858.cd001211.pub3

Cited by 88 publications

(44 citation statements)

References 30 publications

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“…In a recent review of eleven randomized clinical trials with a total of 3,673 participants, it was found that the use of antibiotic eye drops is associated with modestly improved rates of clinical and microbiological remission in comparison to the use of placebo 18. The use of antibiotic eye drops should, therefore, be considered in order to induce resolution of symptoms and infection.…”

Section: Discussionmentioning

confidence: 99%

Listeria monocytogenes endophthalmitis following keratoconjunctivitis

Shoughy

Tabbara²

2014

OPTH

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Endophthalmitis due to endogenous or exogenous bacteria is a rare infection of the eye. We report a case of endophthalmitis following Listeria monocytogenes keratoconjunctivitis in a 27-year-old healthy white male presenting with hand motion visual acuity, right eye mucopurulent conjunctivitis, elevated intraocular pressure, and pigmented hypopyon 6 months post-keratectomy. The conjunctivitis was unresponsive to a 5-day course of topical tobramycin eye drops, and the patient developed keratitis with pain that progressed to endophthalmitis after 21 days. Diagnostic B-scan revealed vitreous exudates. Intraocular fluid specimen showed Gram-positive organisms and the aqueous culture grew penicillin-/aminoglycoside-sensitive L. monocytogenes. The patient was given intravitreal and systemic vancomycin and ceftazidime. The eye was unresponsive to intravenous penicillin and gentamicin; the anterior chamber progressively flattened and developed phthisis bulbi. L. monocytogenes keratoconjunctivitis may lead to bacterial endophthalmitis. Prompt culture and early antibiotic therapy are recommended.

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Section: Discussionmentioning

confidence: 99%

Listeria monocytogenes endophthalmitis following keratoconjunctivitis

Shoughy

Tabbara²

2014

OPTH

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“…Symptoms include burning, itching, foreign body sensations, discharge, overproduction of tears, and variable presence of papillae (bacterial and allergic conjunctivitis) or follicles (viral or chemical conjunctivitis) [11]. Topically administered antibiotics are most commonly recommended for rapid resolution of the infection and prevention of transmission [12]. Though mild cases have the potential of resolving on their own, the availability of antibiotics specific to children suffering from more severe cases of bacterial conjunctivitis is limited.…”

Section: Pediatric Ocular Diseasesmentioning

confidence: 99%

Pediatric ocular nanomedicines: Challenges and opportunities

Sheybani

2017

Chinese Chemical Letters

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The eye is a highly complex, yet readily accessible organ within the human body. As such, the eye is an appealing candidate target for a vast array of drug therapies. Despite advances in ocular drug therapy research, the focus on pediatric ocular drug delivery continues to be highly underrepresented due to the limited number of degenerative ocular diseases with childhood onset. In this review, we explore more deeply the reasons underlying the disparity between ocular therapies available for children and for adults by highlighting diseases that most commonly afflict children (with focus on the anterior eye) and existing prognoses, recent developments in ocular drug delivery systems and nanomedicines for children, and barriers to use for pediatric patients.

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“…Naturally, if the doctor does not have much time to perform a systematic review and then critically appraise all potentially relevant studies, he might be inclined to follow the advice of well-conducted summaries of evidence. In this respect, current evidence-based guidelines for patients with 'acute conjunctivitis' suggest that this is typically a self-limiting condition in which topical antibiotics offer only marginally better clinical outcomes [22][23][24][25]. In the face of a recommendation backed up by 'gold standard' methods, and assuming that the preferences of Mr Smith are not an obstacle, many doctors would be tempted to conclude that Mr Smith should not receive antibiotics, and that this properly evidence-based clinical advice does not deserve further revision.…”

Section: Section 1: Therapeutic Inferences Unreasonable and Reasonabmentioning

confidence: 99%