Antibiotika: Gesetzgebung und Datenerfassung in Deutschland

Wallmann, Jürgen; Hauck, Rüdiger; Schwarz, Christine; Klee, Sabine; Kaspar, Heike; Heberer, Thomas

doi:10.1007/s00003-015-0954-8

Cited by 7 publications

(11 citation statements)

References 3 publications

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“…For livestock types, Eurostat (2021) describes beef cattle, dairy cattle, pigs, broiler chickens, and laying hens as the most dominant livestock types in the German and Dutch context (Eurostat, 2021). These categories (largely) overlap with those published on antibiotic use in Germany and the Netherlands (Van Geijlswijk et al, 2018;Wallmann et al, 2018). We therefore consider this livestock type categorization suitable for our assessment.…”

Section: Selection Of Livestock Types and Production System Categoriesmentioning

confidence: 97%

“…Although the EU prohibited the use of veterinary antibiotics as growth promoters in 2006 and overall sales in Europe declined, the purchase of more than 6000 tons was reported in 2018 (European Commission, 2005;European Medicines Agency, 2020). In Germany and the Netherlands (the geographical setting of this study), antibiotic use has been decreasing due to different policies (Mevius & Heederik, 2014;Wallmann et al, 2018). Yet, antibiotic use in livestock remains substantial, amounting to hundreds of tons per year (SWAB, 2021;Wallmann et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…In Germany and the Netherlands (the geographical setting of this study), antibiotic use has been decreasing due to different policies (Mevius & Heederik, 2014;Wallmann et al, 2018). Yet, antibiotic use in livestock remains substantial, amounting to hundreds of tons per year (SWAB, 2021;Wallmann et al, 2018). Information about the application of other pharmaceuticals (e.g., antiparasitics or hormones) in livestock remains largely undetermined as there are no comprehensive datasets available (Di Guardo & Finizio, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Water pollution from pharmaceutical use in livestock farming: Assessing differences between livestock types and production systems

Wöhler

Hogeboom

Berger

et al. 2023

Integr Envir Assess & Manag

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Livestock production is a major source of pharmaceutical emissions to the environment. The current scientific discourse focuses on measuring and modeling emissions as well as assessing their risks. Although several studies corroborate the severity of pharmaceutical pollution resulting from livestock farming, differences in pollution between livestock types and production systems are largely unknown. In fact, there is no comprehensive analysis of factors influencing pharmaceutical use—the emission's source—in the diverse production systems. To address these knowledge gaps, we developed a framework to investigate pharmaceutical pollution from different livestock production systems and applied it in a first pilot assessment to compare pollution from organic and conventional cattle, pig, and chicken production systems on selected indicator substances, covering antibiotics, antiparasitics, hormones, and nonsteroidal anti‐inflammatory drugs (NSAIDs). Given the lack of statistics, for this article we retrieved novel qualitative information about influential factors for pharmaceutical use and pollution from expert interviews and combined this with quantitative data on, among other factors, the environmental behavior of specific substances from the literature. Our analysis reveals that factors across a pharmaceutical's entire life cycle influence pollution. However, not all factors are livestock type or production‐system dependent. The pilot assessment furthermore reveals that differences in pollution potential between conventional and organic production exist, but for antibiotics, NSAIDs, and partially for antiparasitics, some factors lead to greater pollution potential in conventional systems, and others in organic systems. For hormones, we identified a comparatively greater pollution potential from conventional systems. Among the indicator substances, the assessment over the entire pharmaceutical life cycle illustrates that flubendazole in broiler production has the greatest per unit impact. The framework and its application in the pilot assessment generated insights useful to identifying which substances, livestock types, production systems, or the combination thereof have great or little pollution potential, informing more sustainable agricultural management practices. Integr Environ Assess Manag 2023;00:1–15. © 2023 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).

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Section: Selection Of Livestock Types and Production System Categoriesmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Water pollution from pharmaceutical use in livestock farming: Assessing differences between livestock types and production systems

Wöhler

Hogeboom

Berger

et al. 2023

Integr Envir Assess & Manag

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“…The aim of the present study was the evaluation of the toxicity of antibiotics from different classes (tetracyclines (TCs), sulfonamides (SAs), and fluoroquinolones (FCs)) on germination and growth of Sinapis alba L. seeds. These three classes of antibiotics are commonly used in veterinary and human medicine, with TCs having a share of 30% of the antibiotics used in Germany in 2011 [13] and about 66% of that used in Europe [14]. SAs are used to a lower degree, with consumption rates of up to 23% in Germany [14] and 10% in the EU in 2012 [15].…”

Section: Introductionmentioning

confidence: 99%

“…In Germany, recent data show a decrease in TC and SA consumption in animal husbandry but an increasing usage of FCs [16]. FCs are used with a growing proportion in the last years because of their higher activity and were detected quite frequently in farm-derived fertilizers [13,16].…”

Section: Introductionmentioning

confidence: 99%

Toxic Effects of Single Antibiotics and Antibiotics in Combination on Germination and Growth of Sinapis alba L.

Timmerer

Lehmann

Schnug

et al. 2020

Plants

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Antibiotics enter agro-ecosystems via the application of farmyard manure, sewage sludge, animal by-products, or digestates. There are many open questions regarding the behavior of such compounds in the soil like their adsorption, degradation, half-life, and their effects on soil organisms and plants. The impact of antibiotics on the development of antibiotic resistance genes in the environment is regarded as the most important effect that endangers the environment as well as human health. Nevertheless, direct plant toxicity, especially of different antibiotics and heavy metals at the same time, can be of importance as well. In the current study, commercially available phytotoxkits were tested with regard to the toxicity of single antibiotics and antibiotics in combination with the root growth of Sinapis alba L. Additionally, a pot trial was conducted to study the transfer of the observed phytotoxkits results in more complex systems. The phytotoxkits revealed direct toxicity of antibiotics on root development only at high concentrations. The highest toxicity was determined for sulfadiazine, followed by tetracycline and enrofloxacin, showing the least toxicity. When two antibiotics were tested at the same time in the phytotoxkit, synergistic effects were detected. The pot trial indicated lower effect concentrations for enrofloxacin than determined in the phytotoxkit and, therefore, to higher toxicity on plant growth.

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Use of Antibiotics and Antimicrobial Resistance in Veterinary Medicine as Exemplified by the Swine Pathogen Streptococcus suis

Seitz

Valentin‐Weigand

Willenborg

2016

Current Topics in Microbiology and Immunology

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Use of antimicrobial agents in veterinary medicine is essential to control infectious diseases, thereby keeping animals healthy and animal products safe for the consumer. On the other hand, development and spread of antimicrobial resistance is of major concern for public health. Streptococcus (S.) suis reflects a typical bacterial pathogen in modern swine production due to its facultative pathogenic nature and wide spread in the pig population. Thus, in the present review we focus on certain current aspects and problems related to antimicrobial use and resistance in S. suis as a paradigm for a bacterial pathogen affecting swine husbandry worldwide. The review includes (i) general aspects of antimicrobial use and resistance in veterinary medicine with emphasis on swine, (ii) genetic resistance mechanisms of S. suis known to contribute to bacterial survival under antibiotic selection pressure, and (iii) possible other factors which may contribute to problems in antimicrobial therapy of S. suis infections, such as bacterial persister cell formation, biofilm production, and co-infections. The latter shows that we hardly understand the complexity of factors affecting the success of antimicrobial treatment of (porcine) infectious diseases and underlines the need for further research in this field.

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Antibiotika: Gesetzgebung und Datenerfassung in Deutschland

Cited by 7 publications

References 3 publications

Water pollution from pharmaceutical use in livestock farming: Assessing differences between livestock types and production systems

Water pollution from pharmaceutical use in livestock farming: Assessing differences between livestock types and production systems

Toxic Effects of Single Antibiotics and Antibiotics in Combination on Germination and Growth of Sinapis alba L.

Use of Antibiotics and Antimicrobial Resistance in Veterinary Medicine as Exemplified by the Swine Pathogen Streptococcus suis

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