Antibiotypes and high frequency of toxin genes in methicillin-resistant Staphylococcus pseudintermedius from nares of dogs and dog guardians in Nigeria

Benjamin, Moses Ikechukwu; Okechukwu, Esimone Charles; Romanus, Iroha Ifeanyichukwu; Rubin, Joseph E.; Sniatynsky, M.K.; Ribeiro, Ághata Cardoso da Silva; Santos, Fernanda dos; Silva, Rodrigo Cayô da; Gales, Ana Cristina

doi:10.1016/j.cimid.2022.101870

Cited by 8 publications

(8 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…S . pseudintermedius grows as small blue colonies on CHROMagar Staph aureus TM and as small, creamy grey-to-white, round 1–3 mm colonies with β-haemolysis on Columbia sheep blood agar [ 20 ]. The morphological appearances of S .…”

Section: Identification Of S Pseudinter...mentioning

confidence: 99%

“…aureus are shown in Figure 1 . They are Gram-positive cocci in bunches with positive catalase test, typical of other staphylococci [ 20 ]. In addition, S .…”

Section: Identification Of S Pseudinter...mentioning

confidence: 99%

“…pseudintermedius from S . aureus [ 5 , 20 , 22 ] ( Table 1 ). The introduction of new advanced technologies such as MALDI-TOF MS, PCR amplification of species-specific target genes such as the thermonuclease ( nuc ) gene [ 23 ], which differentiates S .…”

Section: Identification Of S Pseudinter...mentioning

confidence: 99%

“…S . pseudintermedius is equipped with a variety of virulence factors such as enterotoxins, coagulase, protease, haemolysin, siet exfoliative toxin, and sec canine enterotoxin, which empowers it to overcome the immune system arsenals and further increase the severity of infections in the infected host [ 20 , 21 ]. Of great interest is the possession of a leukotoxin virulence gene known as luk by S .…”

Section: Virulence Factors Of S Pseudin...mentioning

confidence: 99%

“…pseudintermedius , which is similar to the Panton–Valentine leucocidin ( PVL ) found in S . aureus [ 20 , 22 ]. The SpsQ and protein A found in S .…”

Section: Virulence Factors Of S Pseudin...mentioning

confidence: 99%

See 4 more Smart Citations

Human Colonization and Infection by Staphylococcus pseudintermedius: An Emerging and Underestimated Zoonotic Pathogen

2023

Self Cite

View full text Add to dashboard Cite

S. pseudintermedius is a known resident of the skin and mucous membranes and a constituent of the normal microbiota of dogs. It has also been recognized as an opportunistic and zoonotic pathogen that is able to colonize humans and cause severe diseases, especially in immunocompromised hosts. Most importantly, methicillin-resistant S. pseudintermedius (MRSP), which is intrinsically multidrug-resistant, has emerged with serious public health consequences. The epidemiological situation is further exacerbated with reports of its zoonotic transmission and human infections which have been mostly attributed to the increasing frequency of dog ownership and close contact between dogs and humans. Evidence on the zoonotic transmission of MRSP from pet dogs to humans (such as dog owners, small-animal veterinarians, and other people in close proximity to dogs) is limited, especially due to the misidentification of S. pseudintermedius as S. aureus. Despite this fact, reports on the increasing emergence and spread of MRSP in humans have been increasing steadily over the years since its first documented report in 2006 in Belgium. The emergence of MRSP strains has further compromised treatment outcomes in both veterinary and human medicine as these strains are resistant to beta-lactam antimicrobials usually prescribed as first line treatment. Frustratingly, the limited awareness and surveillance of the zoonotic transmission of S. pseudintermedius have underestimated their extent of transmission, prevalence, epidemiology, and public health significance. In order to fill this gap of information, this review focused on detailed reports on zoonotic transmission, human colonization, and infections by S. pseudintermedius, their pathogenic features, antimicrobial resistance profiles, epidemiology, risk factors, and treatment. In writing this review, we searched Web of Science, PubMed, and SCOPUS databases using the keyword “Staphylococcus pseudintermedius AND humans”. A phylogenetic tree to determine the genetic relatedness/diversity of publicly available genomes of S. pseudintermedius was also constructed.

show abstract

Section: Identification Of S Pseudinter...mentioning

confidence: 99%

“…aureus are shown in Figure 1 . They are Gram-positive cocci in bunches with positive catalase test, typical of other staphylococci [ 20 ]. In addition, S .…”

Section: Identification Of S Pseudinter...mentioning

confidence: 99%

Section: Identification Of S Pseudinter...mentioning

confidence: 99%

Section: Virulence Factors Of S Pseudin...mentioning

confidence: 99%

“…pseudintermedius , which is similar to the Panton–Valentine leucocidin ( PVL ) found in S . aureus [ 20 , 22 ]. The SpsQ and protein A found in S .…”

Section: Virulence Factors Of S Pseudin...mentioning

confidence: 99%

See 3 more Smart Citations